| Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function. | Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function.
Zecchinati F, Barranco MM, Tocchetti GN, Domínguez CJ, Arana MR, Perdomo VG, Mottino AD, García F, Villanueva SSM. | 10/9/2021 |
| Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism. | Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism.
Tocchetti GN, Domínguez CJ, Zecchinati F, Arana MR, Rigalli JP, Ruiz ML, Villanueva SSM, Mottino AD. | 09/25/2021 |
| we demonstrate redistribution of intestinal MRP2 between plasma membrane and intracellular membrane in rat jejunum and in Caco-2 cells in response to db-cAMP and estradiol-17beta-D-glucuronide | Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells.
Tocchetti GN, Arias A, Arana MR, Rigalli JP, Domínguez CJ, Zecchinati F, Ruiz ML, Villanueva SSM, Mottino AD. | 01/19/2019 |
| In conclusion, our data supports the hypothesis that isoniazid can induce liver injury via the down-regulation of hepatic efflux transporters BSEP and MRP2, and the SIRT1/FXR pathway may be the primary regulator with regard to the expression of transporters and the biosynthesis of bile acids in the liver. | Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells.
Qu X, Zhang Y, Zhang S, Zhai J, Gao H, Tao L, Song Y. | 10/20/2018 |
| Bile transporters OATP1/MRP2 mRNA expression ratio in liver tissue decreased with dimethylnitrosamine-induced liver injury, model of liver cirrhosis. | Pre-Hepatectomy Assessment of Bile Transporter Expression by Gadoxetic Acid-Enhanced MRI in a Rat Model of Liver Cirrhosis.
Kim J, Kim T, Hong KS, Moon H, Oh IK, Lee SM, Hohenwalter MD, Zimmerman MA, Cronin DC, Hong JC. | 03/17/2018 |
| GLP-2 can prevent down-regulation of intestinal expression and activity of Mrp2 and P-gp in endotoxemic rats. | Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.
Arana MR, Tocchetti GN, Zecchinati F, Londero AS, Dominguez C, Perdomo V, Rigalli JP, Villanueva SSM, Mottino AD. | 10/28/2017 |
| Calculus Bovis administration can alleviate liver injury and up-regulate the expression of BSEP and MRP2 in 17alpha-ethynylestradiol-induced cholestasis by a mechanism that may involve inhibiting the activated PI3K/Akt signaling pathway. | Up-regulation of BSEP and MRP2 by Calculus Bovis administration in 17α-ethynylestradiol-induced cholestasis: Involvement of PI3K/Akt signaling pathway.
Wu T, Zhang Q, Li J, Chen H, Wu J, Song H. | 04/22/2017 |
| The data of this study show increased Abcc1, Abcc2, and Abcc4 mRNA expression at the BBB in response to H/R stress and that Abcc gene expression is regulated by Nrf2 signaling. | Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress.
Ibbotson K, Yell J, Ronaldson PT., Free PMC Article | 03/25/2017 |
| results suggest that YZH has protective effect against ANIT-induced intrahepatic cholestasis in rats, through upregulation of Mrp2 and Bsep expressions | Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions.
Ou QQ, Qian XH, Li DY, Zhang YX, Pei XN, Chen JW, Yu L. | 02/4/2017 |
| Abcc2 role in cholestasis: EGFR is a key factor in the alteration of Abcc2 canalicular transporter function in hepatocytes. | EGFR participates downstream of ERα in estradiol-17β-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets.
Barosso IR, Zucchetti AE, Miszczuk GS, Boaglio AC, Taborda DR, Roma MG, Crocenzi FA, Sánchez Pozzi EJ. | 12/17/2016 |
| Serum 5-HT regulates the expression of Mrp2 and P-gp, and the underlying mechanism may be related to the altered expression of the nuclear receptor constitutive androstane receptor. | Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats.
Shao YY, Huang J, Ma YR, Han M, Ma K, Qin HY, Rao Z, Wu XA. | 05/7/2016 |
| These findings suggest the possibility that ABCC2-mediated hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do not play important roles in the disposition of regorafenib. | Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats.
Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, Matsuura K, Hasegawa T. | 04/30/2016 |
| Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats. | Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats.
Kosaka K, Watanabe T, Susukida T, Aoki S, Sekine S, Kume T, Ito K. | 04/2/2016 |
| Multidrug resistance-associated proteins 1, 4, 5, and Oatp1a4 were present at the transcript level, but only Mrp1, 4, and 5 were detected at the protein level. | Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens.
Umapathy A, Li B, Donaldson PJ, Lim JC. | 10/31/2015 |
| hyperammonemia increases the function and expression of P-glycoprotein and multidrug resistance-associated protein 2 at the blood-brain barrier via activating NF-kappaB pathway | Hyperammonemia enhances the function and expression of P-glycoprotein and Mrp2 at the blood-brain barrier through NF-κB.
Zhang J, Zhang M, Sun B, Li Y, Xu P, Liu C, Liu L, Liu X. | 03/7/2015 |
| The pericentral downregulation of Bsep and Mrp2 following cold I/R is ameliorated by inducing HO-1 and was associated with diminished hepatocellular JNK and Fyn signaling. | HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion.
Donner MG, Topp SA, Cebula P, Krienen A, Gehrmann T, Sommerfeld A, Reinehr R, Macher A, Herebian D, Mayatepek E, Pannen BH, Knoefel WT, Häussinger D. | 10/4/2014 |
| Gene expression and pathology changes are systematically examined in Mrp2 knockout rats for microsopic increases in the size of hepatocytes and kidney glomeruli. | Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
Zamek-Gliszczynski MJ, Goldstein KM, Paulman A, Baker TK, Ryan TP. | 02/8/2014 |
| The utility of noninvasive DCE-MRI with Gd-EOB-DTPA as a tool for the assessment of Mrp2-deficient hyperbilirubinuria rats was demonstrated. | Dynamic contrast-enhanced MRI of the liver in Mrp2-deficient rats using the hepatobiliary contrast agent Gd-EOB-DTPA.
Saito S, Obata A, Kashiwagi Y, Abe K, Murase K. | 01/11/2014 |
| The Multidrug Resistance-associated Protein 2 (MRP2) as a possible regulator of CP traffic and accumulation in normal and pathological conditions. | Role of Multidrug-Resistance Protein 2 in coproporphyrin transport: results from experimental studies in bile fistula rat models.
Moriondo V, Marchini S, Di Gangi P, Ferrari MC, Nascimbeni F, Rocchi E, Ventura P. | 12/28/2013 |
| Gender-related differences in pharmacokinetics of ofloxacin may be attributed to the differences in the expression of Mrp2 in kidney of male and female rats. | Pharmacokinetic variation of ofloxacin based on gender-related difference in the expression of multidrug resistance-associated protein (Abcc2/Mrp2) in rat kidney.
Wang D, Wei YH, Zhou Y, Zhang GQ, Zhang F, Li YQ, Zhang JP, Wu XA. | 09/28/2013 |
| This study aims to characterise transport of statins by human and rat MRP2/Mrp2 using membrane and vesicle preparations. | ATP-dependent transport of statins by human and rat MRP2/Mrp2.
Ellis LC, Hawksworth GM, Weaver RJ. | 06/22/2013 |
| Thioacetamide-induced acute liver failure increased brain MRP2 levels at 6, 12 and 24 h after induction. | P-glycoprotein and multidrug resistance-associated protein 2 are oppositely altered in brain of rats with thioacetamide-induced acute liver failure.
Jin S, Wang XT, Liu L, Yao D, Liu C, Zhang M, Guo HF, Liu XD. | 06/15/2013 |
| study shows ability of EGCG to raise plasma bile acid concentrations, mainly through Cyp7a1 upregulation, and to decrease bile production through reduction in Mrp2-mediated bile acid-independent bile flow | Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.
Hirsova P, Karlasova G, Dolezelova E, Cermanova J, Zagorova M, Kadova Z, Hroch M, Sispera L, Tomsik P, Lenicek M, Vitek L, Pavek P, Kucera O, Cervinkova Z, Micuda S. | 03/9/2013 |
| Decreased Mrp2 transport in severe macrovesicular fatty liver grafts. | Decreased Mrp2 transport in severe macrovesicular fatty liver grafts.
Kudo A, Ban D, Aihara A, Irie T, Ochiai T, Nakamura N, Tanaka S, Arii S. | 03/2/2013 |
| hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis | The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis.
Cherrington NJ, Estrada TE, Frisk HA, Canet MJ, Hardwick RN, Dvorak B, Lux K, Halpern MD., Free PMC Article | 02/23/2013 |