| PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1, and Rev-erbalpha gene regulation, behavioral analysis, and antioxidant capacity of Gum Arabic. | PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1, and Rev-erbα gene regulation, behavioral analysis, and antioxidant capacity of Gum Arabic.
Yakmaz F, Bozkurt AS, Görücü Yilmaz Ş. | 03/12/2024 |
| Rev-erbalpha attenuates refractory periapical periodontitis via M1 polarization: An in vitro and in vivo study. | Rev-erbα attenuates refractory periapical periodontitis via M1 polarization: An in vitro and in vivo study.
Song W, Ye L, Tang Q, Lu X, Huang X, Xie M, Yu S, Yuan Z, Chen L. | 03/7/2024 |
| Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging. | Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging.
Noh SG, Jung HJ, Kim S, Arulkumar R, Kim DH, Park D, Chung HY., Free PMC Article | 10/1/2022 |
| Central administration of REV-ERBalpha agonist promotes opposite responses on energy balance in fasted and fed states. | Central administration of REV-ERBα agonist promotes opposite responses on energy balance in fasted and fed states.
Borba TKF, Toscano AE, Costa de Santana BJR, Silva SCA, Lagranha CJ, Guzmán Quevedo O, Manhães-de-Castro R. | 05/15/2021 |
| findings indicate that the attenuation of REV-ERBalpha leads to an upregulation of Gdf10 and Gdf15 in decidual cells | The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.
Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA., Free PMC Article | 09/10/2016 |
| REV-ERBalpha has a role in circadian oscillation in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells | Integration of the nuclear receptor REV-ERBα linked with circadian oscillators in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells.
Chen H, Isayama K, Kumazawa M, Zhao L, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA. | 04/23/2016 |
| Bone morphogenetic protein gene expression is inhibited by REV-ERBalpha which acts as a transcriptional silencer. | Inhibitory role of REV-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells.
Tasaki H, Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA. | 06/20/2015 |
| Data (including data from studies in transgenic rats) suggest attenuation of circadian clock system, especially Rev-erb-alpha, contributes to induction of prostaglandin G/H synthase 2 in endometrial stromal cells during decidualization/placentation. | Removal of Rev-erbα inhibition contributes to the prostaglandin G/H synthase 2 expression in rat endometrial stromal cells.
Isayama K, Zhao L, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA. | 06/20/2015 |
| REV-ERBalpha plays an important role in ventilation induced lung injury (VILI) and inflammation, and circadian rhythm disorder inflammation response may be a novel pathogenesis of VILI. | A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury.
Li H, Wang C, Hu J, Tan J. | 09/27/2014 |
| Rev-erbalpha is a novel regulator of hepatic stellate cell transdifferentation | Novel role of nuclear receptor Rev-erbα in hepatic stellate cell activation: potential therapeutic target for liver injury.
Li T, Eheim AL, Klein S, Uschner FE, Smith AC, Brandon-Warner E, Ghosh S, Bonkovsky HL, Trebicka J, Schrum LW. | 08/9/2014 |
| type 2 diabetes amelioration in diabetic GK rats was associated with improved circadian Rev-erbalpha expression, in a comparison between the surgically treated and untreated GK rats. | Association of Rev-erbα in adipose tissues with Type 2 diabetes mellitus amelioration after gastric bypass surgery in Goto-Kakizaki rats.
Zhang R, Yan C, Zhou X, Qian B, Li F, Sun Y, Shi C, Li B, Saito S, Horimoto K, Zhou H. | 09/28/2013 |
| these data are the first to show the Rev-erbalpha function in the steroid biosynthesis of rat granulosa cells, and to suggest that Rev-erbalpha may coordinate circadian rhythm and metabolism in rat ovaries. | Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.
Chen H, Chu G, Zhao L, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA. | 05/26/2012 |
| Restricted feeding induced significant circadian rhythms in Rev-erbalpha and Bmal1 gene expressionin rats maintained under constant light | Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light.
Nováková M, Polidarová L, Sládek M, Sumová A. | 03/3/2012 |
| N-nitroso-N-methylurea disrupted and dietary methylselenocysteine significantly increased the expression of RevErbaAlpha in mammary glands of Fischer 344 rats | Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo.
Fang MZ, Zhang X, Zarbl H., Free PMC Article | 08/2/2010 |
| ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner | Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner.
Meng QJ, McMaster A, Beesley S, Lu WQ, Gibbs J, Parks D, Collins J, Farrow S, Donn R, Ray D, Loudon A., Free PMC Article | 01/21/2010 |
| Rev-Erbalpha as a target gene of PPARgamma in adipose tissue and demonstrate a role for this nuclear receptor as a promoter of adipocyte differentiation. | The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation.
Fontaine C, Dubois G, Duguay Y, Helledie T, Vu-Dac N, Gervois P, Soncin F, Mandrup S, Fruchart JC, Fruchart-Najib J, Staels B. | 01/21/2010 |