| Vascular endothelial damage in Lipopolysaccharide-induced sepsis model is attenuated by activated protein C. | The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage.
Iba T, Nagakari K. | 01/30/2016 |
| APC treatment significantly improves pial microcirculation by reducing leukocyte adhesion and increasing functional capillary density | Activated protein C improves pial microcirculation in experimental endotoxemia in rats.
Zhou J, Pavlovic D, Willecke J, Friedel C, Whynot S, Hung O, Cerny V, Schroeder H, Wendt M, Shukla R, Lehmann C. | 08/11/2012 |
| mutated Protein C did not appear to alter the levels of NFkB or fibrinogen in our model of hemorrhagic shock and resuscitation. | Effect of protein C gene mutation on coagulation and inflammation in hemorrhagic shock.
Burruss S, Andakyan A, Romanov S, Semiletova N, Cryer H. | 06/30/2012 |
| Xuebijing could upregulate EPCR and PAR1 mRNA and protein expression of rat aortic endothelial cells after LPS challenge. | [Effect of Xuebijing injection on expression of endothelial protein C receptor and protease activated receptor 1 mRNA and protein in endothelial cells induced by lipopolysaccharide].
Zheng GJ, Wu ZX, Li YP, Yao YM. | 05/31/2010 |
| activated protein C induces the reduction of the nuclear level of NF-kappaB p65 in hippocampal neurons at glutamate-induced excitotoxicity via binding to EPCR and subsequent PAR-1 activation and signaling | Activated protein C prevents glutamate- and thrombin-induced activation of nuclear factor-kappaB in cultured hippocampal neurons.
Gorbacheva L, Pinelis V, Ishiwata S, Strukova S, Reiser G. | 03/15/2010 |
| Activated protein C is a promising therapeutic option for hepatic ischaemia-reperfusion injury. | Activated protein C prevents hepatic ischaemia-reperfusion injury in rats.
Kuriyama N, Isaji S, Hamada T, Kishiwada M, Ohsawa I, Usui M, Sakurai H, Tabata M, Suzuki K, Uemoto S. | 01/21/2010 |
| although PAR-1 agonism is solely responsible for APC-mediated improvement in systemic hemodynamics, both functions of APC play distinct roles in attenuating the response to injury in the kidney | Distinct functions of activated protein C differentially attenuate acute kidney injury.
Gupta A, Gerlitz B, Richardson MA, Bull C, Berg DT, Syed S, Galbreath EJ, Swanson BA, Jones BE, Grinnell BW., Free PMC Article | 01/21/2010 |
| NO generated immediately after isoflurane exposure triggers downstream activation of NF-kappaB, resulting in subsequent upregulation of iNOS expression and NO synthesis that mediate APC-induced delayed cardioprotection | Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase.
Chen CH, Chuang JH, Liu K, Chan JY. | 01/21/2010 |
| APC at low concentrations, activating PAR1, prevents the death of hippocampal and cortical neurons under conditions of glutamate excitotoxicity. | Activated protein C via PAR1 receptor regulates survival of neurons under conditions of glutamate excitotoxicity.
Gorbacheva LR, Storozhevykh TP, Pinelis VG, Davydova ON, Ishiwata S, Strukova SM. | 01/21/2010 |
| Low levels of protein C (PC) predict outcome as early as 10 hr after insult in a rat polymicrobial sepsis model and are associated with suppression of PC mRNA. | FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis.
Berg DT, Gerlitz B, Sharma GR, Richardson MA, Stephens EJ, Grubbs RL, Holmes KC, Fynboe K, Montani D, Cramer MS, Engle SD, Jakubowski JA, Heuer JG, Grinnell BW., Free PMC Article | 01/21/2010 |
| APC reduces stress-induced gastric mucosal injury by inhibiting the decrease in gastric mucosal blood flow through attenuation of the activated neutrophil-induced endothelial cell injury via inhibition of TNF-alpha production. | Activated protein C reduces stress-induced gastric mucosal injury in rats by inhibiting the endothelial cell injury.
Isobe H, Okajima K, Harada N, Liu W, Okabe H. | 01/21/2010 |