| P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy. | P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy.
Zaripova KA, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL. | 01/3/2024 |
| Abeta1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes. | Aβ(1-42) peptides blunt the adenosine A(2A) receptor-mediated control of the interplay between P(2)X(7) and P(2)Y(1) receptors mediated calcium responses in astrocytes.
Dias L, Madeira D, Dias R, Tomé ÂR, Cunha RA, Agostinho P., Free PMC Article | 08/6/2022 |
| Transcutaneous auricular vagal nerve stimulation inhibits hypothalamic P2Y1R expression and attenuates weight gain without decreasing food intake in Zucker diabetic fatty rats. | Transcutaneous auricular vagal nerve stimulation inhibits hypothalamic P2Y1R expression and attenuates weight gain without decreasing food intake in Zucker diabetic fatty rats.
Yu Y, He X, Zhang J, Tang C, Rong P., Free PMC Article | 04/30/2022 |
| P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8-Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion. | P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8-Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion.
Su L, Bai X, Niu T, Zhuang X, Dong B, Li Y, Yu Y, Wang G. | 09/25/2021 |
| A Role for The P2Y1 Receptor in Nonsynaptic Cross-depolarization in the Rat Dorsal Root Ganglia. | A Role for The P2Y1 Receptor in Nonsynaptic Cross-depolarization in the Rat Dorsal Root Ganglia.
Carvalho GB, Mulpuri Y, Damasio A, Spigelman I. | 09/19/2020 |
| ATP/ADP through the activation of P2Y1R contributes to glutamate-induced neuronal death in the rat hippocampus. | Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
Simões AP, Silva CG, Marques JM, Pochmann D, Porciúncula LO, Ferreira S, Oses JP, Beleza RO, Real JI, Köfalvi A, Bahr BA, Lerma J, Cunha RA, Rodrigues RJ., Free PMC Article | 10/26/2019 |
| P2Y1R plays a regulatory role in visceral hypersensitivity in rats with experimental irritable bowel syndrome. | P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome.
Wu J, Cheng Y, Zhang R, Liu D, Luo YM, Chen KL, Ren S, Zhang J., Free PMC Article | 06/2/2018 |
| These data are supporting the idea of a dynamic modulation of astrocytic processes by purinergic signal, strengthening the role of purines in brain homeostasis. | Purinergic P2Y1 Receptors Control Rapid Expression of Plasma Membrane Processes in Hippocampal Astrocytes.
Chisari M, Scuderi A, Ciranna L, Volsi GL, Licata F, Sortino MA. | 04/14/2018 |
| Data indicate the involvement of P2Y1Rs in interleukin-1beta (IL-1beta) mediated pain in both naive and carrageenan injected rats. There is a positive interaction between peripheral P2Y1Rs and interleukin-1 receptors in both IL-1beta and carrageenan-induced thermal hypersensitivity. | Involvement of peripheral P2Y1 receptors and potential interaction with IL-1 receptors in IL-1β-induced thermal hypersensitivity in rats.
Kwon SG, Roh DH, Yoon SY, Choi SR, Choi HS, Moon JY, Kang SY, Beitz AJ, Lee JH. | 02/24/2018 |
| Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy. | Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Gremmel T, Yanachkov IB, Yanachkova MI, Wright GE, Wider J, Undyala VV, Michelson AD, Frelinger AL 3rd, Przyklenk K., Free PMC Article | 07/16/2016 |
| Data demonstrate that P2X7 and P2Y1 activation contributes to early damage induced by oxygen and glucose deprivation in the dentate gyrus (DG) with perhaps additional role for P2Y1 receptors in promoting cell proliferation and maturation in the DG. | The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.
Maraula G, Lana D, Coppi E, Gentile F, Mello T, Melani A, Galli A, Giovannini MG, Pedata F, Pugliese AM., Free PMC Article | 12/26/2015 |
| Results suggest that activation of P2Y1 receptors in the medial prefrontal cortex impairs inhibitory control and behavioral flexibility mediated by increased mesocorticolimbic activity and local disinhibition | Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex.
Koch H, Bespalov A, Drescher K, Franke H, Krügel U., Free PMC Article | 12/19/2015 |
| P2Y1 receptors are a potential pharmacological target leading smooth muscle relaxation to treat spasticity in colonic motor disorders. | α,β-meATP mimics the effects of the purinergic neurotransmitter in the human and rat colon.
Martínez-Cutillas M, Gil V, Gallego D, Mañé N, Clavé P, Martín MT, Jiménez M. | 10/31/2015 |
| Results suggest that peripheral activation of P2Y1, P2Y6 and P2Y11 receptors plays a pronociceptive role in formalin-induced pain. | Participation of peripheral P2Y1, P2Y6 and P2Y11 receptors in formalin-induced inflammatory pain in rats.
Barragán-Iglesias P, Mendoza-Garcés L, Pineda-Farias JB, Solano-Olivares V, Rodríguez-Silverio J, Flores-Murrieta FJ, Granados-Soto V, Rocha-González HI. | 09/26/2015 |
| P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro | P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro.
Alvares TS, Revill AL, Huxtable AG, Lorenz CD, Funk GD., Free PMC Article | 04/25/2015 |
| FAM3A promotes proliferation and migration of vascular smooth muscle cells via P2Y1 receptor-mediated activation of Akt and ERK1/2 pathways. | FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury.
Jia S, Chen Z, Li J, Chi Y, Wang J, Li S, Luo Y, Geng B, Wang C, Cui Q, Guan Y, Yang J. | 04/4/2015 |
| fibronectin upregulated the expression of P2Y1 receptor in spinal cord, and ATP could enhance the astrocytic proliferation and induce more release of arachidonic acid and prostaglandin E2 via P2Y1. | Fibronectin enhances spinal cord astrocyte proliferation by elevating P2Y1 receptor expression.
Xia M, Zhu Y. | 02/28/2015 |
| P2Y1 receptors in astrocytes inhibit GABA transport through a mechanism dependent of P2Y1-mediated calcium signalling | P2Y1 receptor inhibits GABA transport through a calcium signalling-dependent mechanism in rat cortical astrocytes.
Jacob PF, Vaz SH, Ribeiro JA, Sebastião AM. | 02/7/2015 |
| maintenance of an acidic environment in the ischemic hind paw of thrombus-induced ischemic pain rats results in the phosphorylation of TRPV1 receptors via a PKC-dependent pathway and P2Y1 receptor. | Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain.
Kwon SG, Roh DH, Yoon SY, Moon JY, Choi SR, Choi HS, Kang SY, Han HJ, Beitz AJ, Oh SB, Lee JH., Free PMC Article | 10/4/2014 |
| It was concluded that the glomeruli podocytes and P2Y1 might be involved in the pathogenesis of glomerular injury and could be a target for treatment of kidney diseases. | Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Ilatovskaya DV, Palygin O, Levchenko V, Staruschenko A., Free PMC Article | 01/11/2014 |
| data identify P2Y1 receptors as key determinants of peripheral chemoreceptor regulation of breathing, sympathetic nerve activity, and blood pressure | P2Y1 receptors expressed by C1 neurons determine peripheral chemoreceptor modulation of breathing, sympathetic activity, and blood pressure.
Wenker IC, Sobrinho CR, Takakura AC, Mulkey DK, Moreira TS., Free PMC Article | 10/19/2013 |
| P2Y(1) -receptor-mediated vasodilatation is impaired in superior mesenteric arteries from long-term type 1 diabetic rats. | Mechanisms underlying reduced P2Y(1) -receptor-mediated relaxation in superior mesenteric arteries from long-term streptozotocin-induced diabetic rats.
Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T. | 07/6/2013 |
| The response of acinar cells to ATP is mediated by P2Y (especially P2Y) as well as by P2X purinoceptors. | P2Y purinoceptors induce changes in intracellular calcium in acinar cells of rat lacrimal glands.
Kamada Y, Saino T, Oikawa M, Kurosaka D, Satoh Y. | 09/22/2012 |
| Data show that the inhibition of P2Y1 purinergic receptor (P2Y1R)-mediated extracellular signal-regulated protein kinase 1/2 (ERK1/2) phosphorylation in the spinal cord and dorsal root ganglia can attenuate nociception transmission. | P2Y1 purinoceptor inhibition reduces extracellular signal-regulated protein kinase 1/2 phosphorylation in spinal cord and dorsal root ganglia: implications for cancer-induced bone pain.
Chen J, Wang L, Zhang Y, Yang J. | 08/18/2012 |
| Critical roles are suggested for activating P2Yreceptors and mediating glioma cell mobility and migration, with changes in divalent calcium ions as a mechanistic link between activated receptor and functional response. | Calcium dependence of purinergic subtype P2Y₁ receptor modulation of C6 glioma cell migration.
Jantaratnotai N, McLarnon JG. | 05/5/2012 |