| macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha, IL6, IL1alpha and CXCL2. | The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways.
Duhamel M, Rodet F, Murgoci AN, Desjardins R, Gagnon H, Wisztorski M, Fournier I, Day R, Salzet M., Free PMC Article | 12/31/2016 |
| PC1/3 as an important regulator of vesicle trafficking and secretion in macrophages. | Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion.
Gagnon H, Refaie S, Gagnon S, Desjardins R, Salzet M, Day R., Free PMC Article | 12/14/2013 |
| Chronic ethanol exposure decreases prohormone convertase (pc1/3) immunoreactivity in brain. | Decreased immunoreactivity of the polypeptide precursor pro-opiomelanocortin (POMC) and the prohormone convertase pc1/3 after chronic ethanol exposure in Sprague-Dawley rats.
Navarro M, Cubero I, Thiele TE., Free PMC Article | 11/16/2013 |
| The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin. | Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.
Takahashi T, Ida T, Sato T, Nakashima Y, Nakamura Y, Tsuji A, Kojima M. | 02/8/2010 |
| Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. | Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach.
Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine JP. | 01/21/2010 |
| PC1/PC3 and PC2 (specific to neural and endocrine cells) are absent in undifferentiated bone marrow stromal stem cells, their expression is initiated upon the induction of differentiation | Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs).
Marandi M, Mowla SJ, Tavallaei M, Yaghoobi MM, Jafarnejad SM. | 01/21/2010 |
| our data anticipate the possibility that carboxypeptidase-E, prohormone convertase 1, and prohormone convertase 2 might be potential target for the maturation of somatostatin | Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.
Billova S, Galanopoulou AS, Seidah NG, Qiu X, Kumar U. | 01/21/2010 |
| Leptin regulates hypothalamic PC1 expression and requires prohormone processing into mature peptides. | Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone.
Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA., Free PMC Article | 01/21/2010 |
| Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor | Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ. | 01/21/2010 |
| proGHRH is initially cleave by furin at preproGHRH29-30, followed by a second cleavage at preproGHRH74 primarily by PC1 to generate GHRH and GHRH-RP peptides, respectively. | Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1.
Posner SF, Vaslet CA, Jurofcik M, Lee A, Seidah NG, Nillni EA. | 01/21/2010 |
| Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides | Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides.
Mulcahy LR, Vaslet CA, Nillni EA. | 01/21/2010 |
| The observed decrease in CCK seen with these RNAi treatments further supports a role for PC1 in CCK processing in these cells | Inhibition of prohormone convertase 1 (PC1) expression in cholecystokinin (CCK) expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted.
Beinfeld MC, Vishnuvardhan D, Blum A, Reynolds N, Fannous S, Kitagawa K, Marchand JE. | 01/21/2010 |
| Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132. | Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3.
Creemers JW, Pritchard LE, Gyte A, Le Rouzic P, Meulemans S, Wardlaw SL, Zhu X, Steiner DF, Davies N, Armstrong D, Lawrence CB, Luckman SM, Schmitz CA, Davies RA, Brennand JC, White A. | 01/21/2010 |
| Expression levels of POMC processing enzymes prohormone convertases 1 and 2 (PC1/PC2) were not significantly affected by high dietary salt intake in either WKY or SP-SHR tissues. | Prevalence of melanocortin system transcripts in rat salt homeostasis endocrine tissues.
Wachira SJ, Temoney S, Ramlochansingh C, Hughes-Darden CA. | 01/21/2010 |
| the prohormone convertase cleavage site within the alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway | A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.
Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR. | 01/21/2010 |
| The prohormone convertase (PC) enzyme PC1 together with PC2 and PC5 may represent a redundant system to ensure production of biologically active cholecystokinin in rat brain. | Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain.
Cain BM, Connolly K, Blum A, Vishnuvardhan D, Marchand JE, Beinfeld MC. | 01/21/2010 |
| These data indicate that the transmembrane domain of PC3 plays a key role in sorting the enzyme to the regulated secretory pathway. | The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway.
Lou H, Smith AM, Coates LC, Cawley NX, Loh YP, Birch NP., Free PMC Article | 01/21/2010 |
| catalytic and P domains contribute to the folding and thermodynamic stability of the convertases through reciprocal hydrophobic interactions (prohormone convertase 3 [pc3/pc1]) | Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1).
Ueda K, Lipkind GM, Zhou A, Zhu X, Kuznetsov A, Philipson L, Gardner P, Zhang C, Steiner DF., Free PMC Article | 01/21/2010 |