| FoxO4 controls sGCbeta transcription in vascular smooth muscle. | FoxO4 controls sGCβ transcription in vascular smooth muscle.
Galley JC, Miller MP, Sanker S, Liu M, Sharina I, Martin E, Gomez D, Straub AC., Free PMC Article | 03/5/2022 |
| GUCY1B3 was upregulated in neonatal rat ventricular myocytes in response to ischemia and reperfusion (IR) injury, and restored IR-induced cell death and apoptosis. Other results suggest that GUCY1B3 has an antiapoptotic effect and this effect is mediated by the activation of PKCepsilon and Akt. | The β subunit of soluble guanylyl cyclase GUCY1B3 exerts cardioprotective effects against ischemic injury via the PKCε/Akt pathway.
Wang X, Du W, Li M, Zhang Y, Li H, Sun K, Liu J, Dong P, Meng X, Yi W, Yang L, Zhao R, Hu J. | 06/27/2020 |
| The effect of glucagon-like peptide-2 on the expression of the alpha1, alpha2, and beta1 subunits of soluble guanylyl cyclase, was studied. | Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes.
Velázquez E, Blázquez E, Ruiz-Albusac JM. | 03/2/2013 |
| soluble GCbeta1 plays an important role in the restructuring of the adherens junction in the testis [sGCbeta1] | Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions.
Sarkar O, Xia W, Mruk DD. | 07/28/2011 |
| Identify hydrogen peroxide as an endogenous mediator contributing to the regulation of vascular tone and point to a key role of HuR in sGCbeta1 mRNA stabilization. | H2O2 regulation of vascular function through sGC mRNA stabilization by HuR.
Martín-Garrido A, González-Ramos M, Griera M, Guijarro B, Cannata-Andia J, Rodriguez-Puyol D, Rodriguez-Puyol M, Saura M. | 04/9/2011 |
| Soluble guanylate cyclase is activated by binding of carbon monoxide and YC-1. | Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.
Ibrahim M, Derbyshire ER, Marletta MA, Spiro TG., Free PMC Article | 05/31/2010 |
| soluble guanylate cyclase beta 1 expression in the vasculature of rat skeletal muscle | The expression of soluble guanylate cyclase in the vasculature of rat skeletal muscle.
Fukutani T, Iino S, Nojyo Y. | 03/29/2010 |
| Soluble guanylyl cyclase activity is an important element not only in neurite outgrowth but also in synapse formation and maturation in cerebellar granule cells. | Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M. | 01/21/2010 |
| Report distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation. | Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
Hoffmann LS, Schmidt PM, Keim Y, Schaefer S, Schmidt HH, Stasch JP., Free PMC Article | 01/21/2010 |
| beta1 is a multifunctional protein that regulates chromatin condensation and cell cycle progression, in addition to being an obligate monomer in functional nitric oxide-sensitive guanylyl cyclase heterodimers. | NO-sensitive guanylyl cyclase beta1 subunit is peripherally associated to chromosomes during mitosis. Novel role in chromatin condensation and cell cycle progression.
Pifarré P, Baltrons MA, Földi I, García A. | 01/21/2010 |
| Estradiol physiologically regulates sGC expression and activity in rat anterior pituitary gland. | Nitric oxide sensitive-guanylyl cyclase subunit expression changes during estrous cycle in anterior pituitary glands.
Cabilla JP, Ronchetti SA, Nudler SI, Miler EA, Quinteros FA, Duvilanski BH. | 01/21/2010 |
| characterization of the promoter activity of human sGC alpha(1) and beta(1) subunits and identification of key transcription factors that govern subunit expression under basal and pro-inflammatory conditions and in the presence of ligand NO | Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor.
Marro ML, Peiró C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HH, Hobbs AJ., Free PMC Article | 01/21/2010 |
| Suggest that in coronary arterioles of obese rats, increased activity of sGC leads to an enhanced sensitivity to NO, which may contribute to the maintenance of NO-mediated dilations and coronary perfusion in obesity. | High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation.
Jebelovszki E, Kiraly C, Erdei N, Feher A, Pasztor ET, Rutkai I, Forster T, Edes I, Koller A, Bagi Z. | 01/21/2010 |
| sGC alpha(1) and beta(1) subunit protein levels in the ovary during postnatal development, gonadotropin-induced follicle growth, ovulation, and luteinization as well as in cultured rat granulosa cells | Cell-specific expression and regulation of soluble guanylyl cyclase alpha 1 and beta 1 subunits in the rat ovary.
Shi F, Stewart RL Jr, Perez E, Chen JY, LaPolt PS. | 01/21/2010 |
| Results identify and characterize the minimum functional ligand-binding heme domain derived from soluble guanylate cyclase. | Characterization of functional heme domains from soluble guanylate cyclase.
Karow DS, Pan D, Davis JH, Behrends S, Mathies RA, Marletta MA., Free PMC Article | 01/21/2010 |
| Results demonstrate that hypoxia decreases soluble guanylate cyclase alpha1 and beta1 expression and suggest that, in hypoxic vascular smooth muscle, decreased cyclic GMP synthesis may limit the vasodilator response to nitric oxide. | Hypoxia decreases expression of soluble guanylate cyclase in cultured rat pulmonary artery smooth muscle cells.
Hassoun PM, Filippov G, Fogel M, Donaldson C, Kayyali US, Shimoda LA, Bloch KD. | 01/21/2010 |
| treatment of rat brain astrocytes with betaA decreases their capacity to accumulate cyclic GMP (cGMP) in response to NO as a result of a decreased expression of soluble guanylyl cyclase alpha-1 and beta-1 subunits at the protein and mRNA levels. | Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells.
Baltrons MA, Pedraza CE, Heneka MT, García A. | 01/21/2010 |
| Soluble guanylate cyclases could be the target molecules for controlling neo-vascularization in a subset of human malignant gliomas. | Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3.
Saino M, Maruyama T, Sekiya T, Kayama T, Murakami Y. | 01/21/2010 |
| Expression of sGC beta 1 subunit is tightly coregulated with that of sGC alpha 1 in rat brain, while yet unknown additional regulatory mechanisms affect the Vmax of sGC. | Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation.
Nedvetsky PI, Kleinschnitz C, Schmidt HH. | 01/21/2010 |
| mapping of heme-binding domain | Mapping of heme-binding domains in soluble guanylyl cyclase beta1 subunit.
Namiki S, Hirose K, Iino M. | 01/21/2010 |
| Soluble guanylyl cyclase appears in a specific subset of periglomerular cells in the olfactory bulb. | Soluble guanylyl cyclase appears in a specific subset of periglomerular cells in the olfactory bulb.
Gutièrrez-Mecinas M, Crespo C, Blasco-Ibáñez JM, Gracia-Llanes FJ, Marqués-Marí AI, Martínez-Guijarro FJ. | 01/21/2010 |
| for the function of sGC in vivo, where there is evidence for two nitric oxide-regulated activity states | Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.
Winger JA, Derbyshire ER, Marletta MA. | 01/21/2010 |