| Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats. | Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats.
Brugnoli A, Pisanò CA, Morari M. | 09/25/2021 |
| Our data suggest that the changes in respiratory frequency and tidal volume produced by muscarinic cholinergic stimulation of the pedunculopontine tegmental nucleus is presumably mediated through a Gi-coupled M4 muscarinic receptors. | M4-muscarinic acetylcholine receptor into the pedunculopontine tegmental nucleus mediates respiratory modulation of conscious rats.
Lima JD, Sobrinho CR, Santos LK, Takakura AC, Moreira TS. | 06/6/2020 |
| Study showed that the muscarinic M4 receptor-preferring antagonist tropicamide consistently increased ERK phosphorylation in the striatum and medial prefrontal cortex. | Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors.
He N, Mao LM, Sturich AW, Jin DZ, Wang JQ., Free PMC Article | 04/6/2019 |
| M1 and M4 muscarinic receptors are involved in shock-limiting and shock-activating processes, respectively, on the course of posthemorrhagic abnormalities in systemic and hepatic portal circulation. | Role of various subtypes of muscarinic cholinergic receptors in the development of posthemorrhagic abnormalities in systemic and portal circulation in rats.
Kovalenko NY, Matsievskii DD, Reshetnyak VK. | 03/26/2016 |
| Muscarinic receptor expression is developmentally regulated; M1, M3, and M4 receptors were the main subtypes expressed in oligodendrocyte progenitor cells. | Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation.
De Angelis F, Bernardo A, Magnaghi V, Minghetti L, Tata AM. | 05/11/2013 |
| M4 muscarinic acetylcholine receptors are up-regulated in dorsal root ganglion neurons and may account for increased muscarinic analgesic effects in a diabetic neuropathic pain model. | Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons.
Cao XH, Byun HS, Chen SR, Pan HL., Free PMC Article | 12/3/2011 |
| CaMKII binds and phosphorylates M4 upon Ca2thorn influx to augment the antagonistic action of M4 on D1 signalling and on D1-mediated, cocaine-triggered hyperlocomotion. | CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion.
Stein IS, Hell JW., Free PMC Article | 07/5/2010 |
| In a Ca(2+)-sensitive manner, CaMKIIalpha regulates M4 receptor efficacy and controls the acetylcholine-dopamine balance in the basal ganglia and also the dynamics of movement. | CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function.
Guo ML, Fibuch EE, Liu XY, Choe ES, Buch S, Mao LM, Wang JQ., Free PMC Article | 07/5/2010 |
| investigation of participation of M(4) receptors in neurotransmission at the hippocampal Schaffer collaterals-CA1 synapses; findings support permissive role of M(4) receptors & suggest their necessary participation in synaptic plasticity at these synapses | M4 muscarinic receptors are involved in modulation of neurotransmission at synapses of Schaffer collaterals on CA1 hippocampal neurons in rats.
Sánchez G, Alvares Lde O, Oberholzer MV, Genro B, Quillfeldt J, da Costa JC, Cerveñansky C, Jerusalinsky D, Kornisiuk E. | 01/21/2010 |
| Receptor, Muscarinic M4 activated mTOR protein and its downstream molecule Ribosomal Protein S6 Kinases (70-kDa) in a 1-Phosphatidylinositol 3-Kinase-dependent manner. | Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells.
Chan GP, Wu EH, Wong YH. | 01/21/2010 |
| M4-type muscarinic receptors do not support behavioral flexibility. | Differential involvement of M1-type and M4-type muscarinic cholinergic receptors in the dorsomedial striatum in task switching.
McCool MF, Patel S, Talati R, Ragozzino ME., Free PMC Article | 01/21/2010 |
| No m4-immunolabeling was detected in the rostral part of the thalamus. | Immunolocalization of muscarinic receptor subtypes in the reticular thalamic nucleus of rats.
Oda S, Sato F, Okada A, Akahane S, Igarashi H, Yokofujita J, Yang J, Kuroda M. | 01/21/2010 |
| The m1-m5 muscarinic subtypes mapped to the following chromosomes: Chrm1, chromosome 1; Chrm2, chromosome 4; Chrm3, chromosome 17; Chrm4, chromosome 3; and Chrm5, chromosome 3. | Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus.
Tseng J, Erbe CB, Kwitek AE, Jacob HJ, Popper P, Wackym PA. | 01/21/2010 |
| These results suggest that a diet high in n-6 PUFA, but not of n-3 PUFAs or saturated fat, may selectively alter M2/M4 receptor-mediated signal transduction in the rat brain. | A high n-6 polyunsaturated fatty acid diet reduces muscarinic M2/M4 receptor binding in the rat brain.
du Bois TM, Bell W, Deng C, Huang XF. | 01/21/2010 |
| Data show that M1 muscarinic receptors contribute to, whereas M4 receptors inhibit, dopamine D1 receptor-induced [3H]-cyclic AMP accumulation in rat striatal slices. | M1 muscarinic receptors contribute to, whereas M4 receptors inhibit, dopamine D1 receptor-induced [3H]-cyclic AMP accumulation in rat striatal slices.
Sánchez-Lemus E, Arias-Montaño JA. | 01/21/2010 |
| Transient forebrain ischemia leads to dynamic alterations in the gene expression, protein prevalence, and functionality of muscarinic receptors in the post-ischemic hippocampus at times preceding the degeneration of the vulnerable neurons. | Decreased expression and impaired function of muscarinic acetylcholine receptors in the rat hippocampus following transient forebrain ischemia.
Zhang G, Zhang L, Logan R, Jung BP, Yuen D, Ching Hsu J, Eubanks JH. | 01/21/2010 |
| There is a significant reduction in the level of muscarinic M4 receptors in the spinal cord of acute and chronic arthritic rats compared to controls, suggesting that the M4 receptor subtype may be involved in cholinergic mechanisms of analgesia. | Loss of muscarinic M4 receptors in spinal cord of arthritic rats: implications for a role of M4 receptors in pain response.
Mulugeta E, El-Bakri N, Karlsson E, Elhassan A, Adem A. | 01/21/2010 |
| evidence presented that stimulation of the muscarinic M4 receptor activates the pro-survival PI3K/Akt pathway to induce tuberin phosphorylation | Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells.
Wu EH, Wong YH. | 01/21/2010 |
| novel role for M4 (Chrm4) in the regulation of protein synthesis through its interaction with eEF1A2. | Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2.
McClatchy DB, Knudsen CR, Clark BF, Kahn RA, Hall RA, Levey AI. | 01/21/2010 |