| Differential Ca(2+) mobilization and mast cell degranulation by FcepsilonRI- and GPCR-mediated signaling has been reported. | Differential Ca(2+) mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling.
Chen YC, Chang YC, Chang HA, Lin YS, Tsao CW, Shen MR, Chiu WT. | 06/2/2018 |
| This study reveals a complex regulation for PLSCR1 tyrosine phosphorylation in FcepsilonRI-activated mast cells, and that PLSCR1 sits at a crossroads between Lyn and Fyn pathways. | Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.
Kassas A, Moura IC, Yamashita Y, Scheffel J, Guérin-Marchand C, Blank U, Sims PJ, Wiedmer T, Monteiro RC, Rivera J, Charles N, Benhamou M., Free PMC Article | 12/26/2015 |
| Data suggest M2PK (M2-type pyruvate kinase) is modulated in mast cell degranulation via IgE/FCERI signaling; immediate inhibition of M2PK involves tyrosine phosphorylation; subsequently fructose-1,6-biphosphate accumulates and activates M2PK. | Dual regulation of mast cell degranulation through IgE receptor-mediated modulation of M₂-type pyruvate kinase.
Zheng M, Cho DI, Le HT, Cheon SH, Kim KM. | 05/16/2015 |
| PTP-PEST expression was significantly induced upon FcepsilonRI-crosslinking, and aggregation of FcepsilonRI induced the phosphorylation of PTP-PEST at Ser39, thus resulting in the suppression of PTP activity. | Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
Motohashi S, Koizumi K, Honda R, Maruyama A, Palmer HE, Mashima K. | 08/9/2014 |
| NK-1 receptor is required for the activation of RBL-2H3 cells following FcepsilonRIota engagement and involved in the regulation of mitogen-activated protein kinase signaling pathways | An involvement of neurokinin-1 receptor in FcεRΙ-mediated RBL-2H3 mast cell activation.
Fang X, Hu H, Xie J, Zhu H, Zhang D, Mo W, Zhang R, Yu M., Free PMC Article | 03/16/2013 |
| results reveal intricate functional interactions among different cis-acting elements of IgE receptor in the transcriptional regulation of cox-2. Fyn-->PI 3-kinase-->Akt pathway directly stimulate | Identification of cis-acting elements and signaling components of high affinity IgE receptor that regulate the expression of cyclooxygenase-2.
Cho DI, Kim SY, Zheng M, Jin M, Choi HK, Yi AK, Kim KM. | 11/17/2012 |
| Data show that among expressed chemokines and cytokines, only CCL2, CCL7 and interleukin (IL)-6 were expressed at higher levels following FcepsilonRI-CCR1 costimulation. | Identification of genes and proteins specifically regulated by costimulation of mast cell Fcε Receptor I and chemokine receptor 1.
Aye CC, Toda M, Morohoshi K, Ono SJ. | 07/28/2012 |
| These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. | The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells.
Oliver-Vila I, Saborit-Villarroya I, Engel P, Martin M. | 12/8/2011 |
| Data show that EGFR, via interaction with FcvarepsilonRI and integrin alpha(5), is necessary for allergic inflammation associated with cellular interaction. | Integrin α(5) interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis.
Kim Y, Kim K, Park D, Eom S, Park H, Lee H, Lee YS, Choe J, Hahn JH, Kim YM, Ro JY, Jeoung D. | 06/18/2011 |
| In an immunological model, although serial engagement is not required for rat mast cell signaling, it can influence recruitment of Syk kinase to the receptor and subsequent Syk phosphorylation. | A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.
Nag A, Monine MI, Blinov ML, Goldstein B., Free PMC Article | 11/27/2010 |
| The spatiotemporal dynamics of the redistribution of immunoglobulin E-loaded receptors (IgE-FcepsilonRI) on rat basophilic leukemia-2H3 mast cells, was quatified. | Distribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces.
Spendier K, Carroll-Portillo A, Lidke KA, Wilson BS, Timlin JA, Thomas JL., Free PMC Article | 10/30/2010 |
| Mast cells produce intercellular connections and that mediators are directionally released upon co-stimulation of FcepsilonRI and CCR1. | Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells.
Fifadara NH, Beer F, Ono S, Ono SJ., Free PMC Article | 05/31/2010 |
| Ca(2+) signaling pathway via a sphingosine kinase (SK) is dependent on clathrin. | Cross-linking of FcepsilonRI causes Ca2+ mobilization via a sphingosine kinase pathway in a clathrin-dependent manner.
Ryu SD, Lee HS, Suk HY, Park CS, Choi OH., Free PMC Article | 01/21/2010 |
| Glycosylated FcepsilonRI alpha chain is required for activation of mast cells for IL-4 production by M. pneumoniae. | Inhibition of message for FcepsilonRI alpha chain blocks mast cell IL-4 production induced by co-culture with Mycoplasma pneumoniae.
Luo D, Dai Y, Duffy LB, Atkinson TP., Free PMC Article | 01/21/2010 |
| pineal Fcer1a mRNA levels are controlled by a well described neural pathway | Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?
Ganguly S, Grodzki C, Sugden D, Møller M, Odom S, Gaildrat P, Gery I, Siraganian RP, Rivera J, Klein DC. | 01/21/2010 |