| Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes. | Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
Dai HB, Wang HY, Wang FZ, Qian P, Gao Q, Zhou H, Zhou YB. | 04/23/2022 |
| MicroRNA-26b inhibits oligodendrocyte precursor cell differentiation by targeting adrenomedullin in spinal cord injury. | MicroRNA-26b inhibits oligodendrocyte precursor cell differentiation by targeting adrenomedullin in spinal cord injury.
Cheng L, Wang C, Yao F, Li Z, Liu W, Jing J. | 12/19/2020 |
| results suggest that the increased Adrenomedullin bioactivity induced mechanical allodynia. | Intrathecal administration of adrenomedullin induces mechanical allodynia and neurochemical changes in spinal cord and DRG.
Huang H, Wang M, Hong Y. | 03/16/2019 |
| Study suggests that the increased adrenomedullin receptor signaling mediated the many, but not all, tumor necrosis factor-alpha-induced activities, contributing to peripheral sensitization in neuropathic pain. | Adrenomedullin mediates tumor necrosis factor-α-induced responses in dorsal root ganglia in rats.
Chen Y, Zhang Y, Huo Y, Wang D, Hong Y. | 07/1/2017 |
| Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP. | Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.
Soultanova A, Mikulski Z, Pfeil U, Grau V, Kummer W., Free PMC Article | 05/20/2017 |
| Levels of adrenomedullin peptide fragments respond to pulmonary remodeling in pulmonary hypertension. | Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow.
Li W, Guo A, Wang L, Kong Q, Wang R, Han L, Zhao C. | 12/17/2016 |
| Findings demonstrate a dysregulation of cerebellar adrenomedullin-system during hypertension, and suggest that cerebellar drenomedullin plays an important role in the regulation of blood pressure. | Role of cerebellar adrenomedullin in blood pressure regulation.
Figueira L, Israel A. | 09/17/2016 |
| AM/AMBP-1 accelerated wound healing by promoting angiogenesis, collagen deposition and remodeling | Combination of adrenomedullin with its binding protein accelerates cutaneous wound healing.
Idrovo JP, Yang WL, Jacob A, Ajakaiye MA, Cheyuo C, Wang Z, Prince JM, Nicastro J, Coppa GF, Wang P., Free PMC Article | 02/6/2016 |
| Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2). | Adrenomedullin promotes rat trophoblast stem cell differentiation.
Gao H, Liebenthal DA, Yallampalli U, Yallampalli C., Free PMC Article | 05/23/2015 |
| Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. | Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T., Free PMC Article | 11/22/2014 |
| expression of adrenomedullin and the calcitonin receptor-like receptor system in the rat heart and sensory ganglia in experimentally-induced long-term diabetes | Adrenomedullin and the calcitonin receptor-like receptor system mRNA expressions in the rat heart and sensory ganglia in experimentally-induced long-term diabetes.
Mistrova E, Wiegand S, Sviglerova J, Pfeil U, Kuncova J, Slavikova J, Kummer W, Chottova Dvorakova M. | 08/23/2014 |
| AM in the CSF contributes to the modulation of acute inflammatory pain in the formalin test. | Intrathecal adrenomedullin modulates acute inflammatory pain in the rat formalin test.
Sugimoto Y, Shiraishi S, Yasuda T, Hamada H, Kawamoto M. | 05/17/2014 |
| Epididymal fat and soleus muscles from rat were incubated with ADM at concentration of 100 nM for the study of the gene expression and secretion of tumour necrosis factor (TNF-alpha), EDN-1, leptin, adiponectin, interleukin 1beta (IL-1beta), and IL-6. | Effects of adrenomedullin on tumour necrosis factor alpha, interleukins, endothelin-1, leptin, and adiponectin in the epididymal fat and soleus muscle of the rat.
Liao SB, Wong PF, WSO, Cheung BM, Tang F. | 09/21/2013 |
| This study found that adrenomedullin (ADM), acting through the ADM receptor, had critical roles during preimplantation. | Preimplantation antagonism of adrenomedullin action compromises fetoplacental development and reduces litter size.
Li L, Tang F, O WS. | 12/8/2012 |
| Ethanol consumption increases blood pressure and the expression of adrenomedullin in the vasculature and reduces the relaxation induced by this peptide in the mesenteric arterial bed. | Ethanol consumption alters the expression and reactivity of adrenomedullin in the rat mesenteric arterial bed.
Rocha JT, Hipólito UV, Martins-Oliveira A, Tirapelli DP, Batalhão ME, Carnio EC, Queiroz RH, Coelho EB, Cunha TM, Tanus-Santos JE, Tirapelli CR. | 08/18/2012 |
| Data suggest that developmental adrenomedullin gene expression in various organs follows different patterns; in kidney, adrenomedullin expression may be related to development of the organ. | An ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart.
Wong PF, O WS, Tang F. | 07/21/2012 |
| adrenomedullin showed beneficial effects in the restoration of vascular function through the regulation of vasoactive products derived from COX-2 and iNOS | Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis.
Talero E, Alvarez de Sotomayor M, Sánchez-Fidalgo S, Motilva V. | 03/3/2012 |
| Regulation of progesterone production by ADM in corpora lutea (CL) in culture is pregnancy-stage dependent, inhibitory at early/late pregnancy but stimulatory at mid-pregnancy; expression/secretion of ADM increases w/ size/development of follicle/CL. | Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1.
Li L, O WS, Tang F., Free PMC Article | 02/11/2012 |
| Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats. | Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats.
Zhang J, Zhang BH, Yu YR, Tang CS, Qi YF. | 11/12/2011 |
| The novel finding of this study is that the signal transduction cascade that underlies the enhancement of baroreflex response by adrenomedullin in rat nucleus tractus solitarii is composed sequentially of cAMP/PKA and nNOS/PKG pathways. | Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats.
Yen DH, Chen LC, Shen YC, Chiu YC, Ho IC, Lou YJ, Chen IC, Yen JC., Free PMC Article | 10/8/2011 |
| ADM may play a crucial role in transporting the gametes/embryos by regulating ciliary beating and muscular contraction. | Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct.
Liao SB, Ho JC, Tang F, O WS. | 06/18/2011 |
| ADM peptide concentration exhibited a spatio-temporal pattern in the rat female reproductive system during gestation, this suggests that ADM may play important roles in gestation. | Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation.
Li L, Tang F, O WS., Free PMC Article | 02/26/2011 |
| Adrenomedullin appears to be an endogenous cardiovascular protective peptide and may represent a new therapeutic target for VC treatment. | Adrenomedullin up-regulates osteopontin and attenuates vascular calcification via the cAMP/PKA signaling pathway.
Cai Y, Teng X, Pan CS, Duan XH, Tang CS, Qi YF., Free PMC Article | 02/26/2011 |
| A likely autocrine mechanism development of tolerance to morphine-induced analgesia is supported by the finding that adrenomedullin (AM) immunoreactivity is colocalized with AM receptor components in dorsal root ganglia neurons. | A role for protein kinase C-dependent upregulation of adrenomedullin in the development of morphine tolerance in male rats.
Hong Y, Wang D, Chabot JG, Ma W, Chen P, Quirion R., Free PMC Article | 10/30/2010 |
| study demonstrates that glomerular gene expression of ADM and its receptors are downregulated during anti-Thy1 glomerulonephritis (GN); downregulation of adrenomedullin during GN at the gene level can be improved by ADM application | Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis.
Geissler B, Plank C, Hartner A, Amann K, Struwe FG, Hilgers KF, Rascher W, Dötsch J. | 10/23/2010 |