| Ectopic GABAA receptor beta3 subunit determines Cl(-) / HCO 3 - -ATPase and chloride transport in HEK 293FT cells. | Ectopic GABA(A) receptor β3 subunit determines Cl(-) / HCO3- -ATPase and chloride transport in HEK 293FT cells.
Menzikov SA, Zaichenko DM, Moskovtsev AA, Morozov SG, Kubatiev AA. | 07/3/2021 |
| In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ... | The GABA(A) Receptor β Subunit Is Required for Inhibitory Transmission.
Nguyen QA, Nicoll RA., Free PMC Article | 08/3/2019 |
| Computational docking analysis supports the existence of a histamine binding site at the interface of homooligomeric Beta3 GABA A receptors. | Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABAA receptors.
Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW. | 07/22/2017 |
| The data of this study reveal that GABAA receptor beta2 and beta3 decrease following 1 h of acute restraint stress and may play a critical role in stress-induced hyperalgesia. | Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.
Ma X, Bao W, Wang X, Wang Z, Liu Q, Yao Z, Zhang D, Jiang H, Cui S. | 06/20/2015 |
| Both the Beta3 and delta containing GABA receptors have a unique ethanol binding site at the alpha4/6+Beta3-subunit interface. | Alcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.
Wallner M, Hanchar HJ, Olsen RW., Free PMC Article | 01/31/2015 |
| These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops. | Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.
Kowalczyk S, Winkelmann A, Smolinsky B, Förstera B, Neundorf I, Schwarz G, Meier JC. | 11/16/2013 |
| GABA-A alpha2 and beta3 receptor subunits are present in bone marrow, adipose tissue and adult stem cells and are upregulated following glial differentiation. | Expression of functional γ-aminobutyric acid type A receptors in Schwann-like adult stem cells.
Faroni A, Terenghi G, Magnaghi V. | 04/13/2013 |
| The endogenous sleep pathway in the hypothalamus operates through the beta1- containing GABAAR whereas inhibition of neuronal firing (anaesthesia) by low propofol doses relies on beta3- containing GABAAR. | GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies.
Yanovsky Y, Schubring S, Fleischer W, Gisselmann G, Zhu XR, Lübbert H, Hatt H, Rudolph U, Haas HL, Sergeeva OA. | 06/23/2012 |
| Under conditions of oxygen-glucose deprivation that mimic cerebral ischemia, GABRB3 receptors are depleted from synapses in dendrites, depending on the three arginine residues motif. | Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit.
Smith KR, Muir J, Rao Y, Browarski M, Gruenig MC, Sheehan DF, Haucke V, Kittler JT., Free PMC Article | 04/28/2012 |
| GABA(A)R activity is a potent regulator of the BDNF release during neuronal development, and at the same time, it is strongly enhanced by the activity of the BDNF/TrkB/PI3K/PKC signaling pathway | Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
Porcher C, Hatchett C, Longbottom RE, McAinch K, Sihra TS, Moss SJ, Thomson AM, Jovanovic JN., Free PMC Article | 09/3/2011 |
| early continuous noise rearing decreases the expression levels of GluR2 and GABAA3 and significantly decreased the level of GABAARs relative to AMPARs; these receptors could be involved in the mechanisms responsible for A1 changes after noise rearing | Early continuous white noise exposure alters l-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit glutamate receptor 2 and gamma-aminobutyric acid type a receptor subunit beta3 protein expression in rat auditory cortex.
Xu J, Yu L, Zhang J, Cai R, Sun X. | 04/12/2010 |
| Data show that regulating the efficacy of synaptic inhibition by modulating GABA(A)R membrane trafficking may play a critical role in regulating spine maturity with significant implications for synaptic plasticity together with behavior. | GABA(A) receptor membrane trafficking regulates spine maturity.
Jacob TC, Wan Q, Vithlani M, Saliba RS, Succol F, Pangalos MN, Moss SJ., Free PMC Article | 01/21/2010 |
| the density of surface clusters of GABA(A)R beta2/3 subunits was reduced by D(4), suggesting that the D(4) reduction of GABA(A)R current is associated with a decrease in functional GABA(A)Rs at the plasma membrane. | Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
Graziane NM, Yuen EY, Yan Z., Free PMC Article | 01/21/2010 |
| There is no loss of GABAergic boutons from the denervated area after SNI (neuronal death does not occur in this model) and there is no depletion of GABA or GABA(A) receptors at GABAergic synapses within this region. | Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn.
Polgár E, Todd AJ., Free PMC Article | 01/21/2010 |
| Low pH enhances Gaba A beta 3 receptor steady-state currents by modifying GABA(A) receptor gating properties. | Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization.
Feng HJ, Macdonald RL. | 01/21/2010 |
| Phospho-dependent regulation of AP2 binding to GABA(A)Rs provides a mechanism to specify receptor cell surface number and the efficacy of inhibitory synaptic transmission. | Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission.
Kittler JT, Chen G, Honing S, Bogdanov Y, McAinsh K, Arancibia-Carcamo IL, Jovanovic JN, Pangalos MN, Haucke V, Yan Z, Moss SJ., Free PMC Article | 01/21/2010 |
| The variant of beta3 subunit of GABA(A) receptor, designated as beta3t, is found in germ cells of rat testis and sperm. | Identification and characterization of a novel splice variant of beta3 subunit of GABA(A) receptor in rat testis and spermatozoa.
Li SF, Hu JH, Yan YC, Chen YG, Koide SS, Li YP. | 01/21/2010 |
| during synaptic maturation GABAAR gamma2 and beta3 subunits are able to associate with synaptic and extrasynaptic clusters of gephyrin; data are compatible with a role of gephyrin in GABAAR synaptic stabilization rather than in clusters formation | Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons.
Danglot L, Triller A, Bessis A. | 01/21/2010 |
| Tonic activation of GABA-A receptors in developing hippocampus enhances glutamergic cell excitability and synaptic activity. | In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells.
Marchionni I, Omrani A, Cherubini E., Free PMC Article | 01/21/2010 |
| conclude that receptors can accumulate in slowly equilibrating desensitized states during repetitive receptor activation; results may indicate role for slow phases of desensitization for synaptic function under conditions of repeated receptor activation | Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function.
Bianchi MT, Macdonald RL., Free PMC Article | 01/21/2010 |