| Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits. | Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits.
Hynes T, Fouyssac M, Puaud M, Joshi D, Chernoff C, Stiebahl S, Michaud L, Belin D. | 08/30/2024 |
| Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure. | Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure.
Vilca S, Wahlestedt C, Izenwasser S, Gainetdinov RR, Pardo M., Free PMC Article | 08/2/2023 |
| Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats. | Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats.
Puzzo C, D'Angiò R, Albanese S, Orlando D, Mangili I, Capobianco M, Liberati AS, Adriani W. | 07/12/2023 |
| Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats. | Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
Hamamah S, Hajnal A, Covasa M., Free PMC Article | 06/15/2023 |
| Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference. | Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference.
Shao D, Jiang D, Huang Q, Ren S, Li J, Xiao J, Guan Y, Lai B, Zhao J, Xie F, Hua F. | 05/24/2023 |
| Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior. | Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior.
Festucci F, Annunzi E, Pepe M, Curcio G, D'Addario C, Adriani W. | 09/17/2022 |
| Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats. | Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats.
Xu K, Guo J, Ge M, Yin J, Zhang H, Yin J, Li Y. | 03/5/2022 |
| [Influence of the DAT gene knockout on exchange of essential and toxic trace elements in rats]. | [Influence of the DAT gene knockout on exchange of essential and toxic trace elements in rats].
Shumakova AA, Apryatin SA, Shipelin VA, Efimova EV, Fesenko ZS, Gmoshinski IV. | 10/9/2021 |
| Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats. | Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats.
Mariano S, Pardo M, Buccheri C, Illiano P, Adinolfi A, Lo Russo SLM, Alleva E, Carbone C, Adriani W. | 07/3/2021 |
| Vapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus. | Vapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus.
Brutman JN, Zhang S, Choi P, Zhang Y, Stotts MJ, Michal J, Jiang Z, Davis JF., Free PMC Article | 10/31/2020 |
| The results suggest that interaction between Gbetagamma and DAT plays a critical role in the actions of amphetamine and presents a novel target for modulating the actions of amphetamine in vivo in rats. | G protein βγ subunits play a critical role in the actions of amphetamine.
Mauna JC, Harris SS, Pino JA, Edwards CM, DeChellis-Marks MR, Bassi CD, Garcia-Olivares J, Amara SG, Guajardo FG, Sotomayor-Zarate R, Terminel M, Castañeda E, Vergara M, Baust T, Thiels E, Torres GE., Free PMC Article | 01/18/2020 |
| DAT-KO rats display elevated locomotor activity and restless environmental exploration, associated with a transient anxiety profile; and pronounced stereotypy and compulsive-like behavior. Homozygous DAT-KO rats mantain intact social interaction when tested in a social-preference task, while heterozygous (HET) rats show high inactivity associated with close proximity to the social stimulus. | Behavioral characterization of DAT-KO rats and evidence of asocial-like phenotypes in DAT-HET rats: The potential involvement of norepinephrine system.
Adinolfi A, Zelli S, Leo D, Carbone C, Mus L, Illiano P, Alleva E, Gainetdinov RR, Adriani W. | 04/27/2019 |
| Results show that Gbetagamma activation regulates DAT activity by increasing dopamine (DA) efflux, and suggests that Gbetagamma promotes an efflux-willing state of the transporter and that the activation of a GPCR can lead to a Gbetagamma-dependent DA efflux. Furthermore, the cellular responses that occur following activation of a Galphaq-coupled receptor are the result of multiple signaling pathways mediated by Galpha... | Gβγ subunit activation promotes dopamine efflux through the dopamine transporter.
Garcia-Olivares J, Baust T, Harris S, Hamilton P, Galli A, Amara SG, Torres GE., Free PMC Article | 07/14/2018 |
| BDNF participates in the regulation of the dopamine system by acting on DRD3 and DAT. | Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression.
Li Y, Xia B, Li R, Yin D, Liang W., Free PMC Article | 03/24/2018 |
| Adolescent male Sprague-Dawley rats were split into three groups at four weeks of age: control (water), low-dose methylphenidate (MP) and high-dose MP. Immediately following treatment, HD MP-treated rats had increased DAT and D1R-like binding in several subregions of the basal ganglia. There were no differences between treatment groups in any measure following abstinence. | Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats.
Robison LS, Ananth M, Hadjiargyrou M, Komatsu DE, Thanos PK., Free PMC Article | 12/23/2017 |
| a new genetic rat model with a loss-of-function point mutation in the dopamine transporter (DAT) gene (Slc6a3_N157K) was used to systematically study the research domain criteria matrix. | Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.
Vengeliene V, Bespalov A, Roßmanith M, Horschitz S, Berger S, Relo AL, Noori HR, Schneider P, Enkel T, Bartsch D, Schneider M, Behl B, Hansson AC, Schloss P, Spanagel R., Free PMC Article | 12/9/2017 |
| Study compared showing a clear-cut profile of either gambling proneness or aversion, found a selective down-regulation of i) serotonin transporter in prefrontal cortex, ii) tyrosine hydroxylase in ventral striatum, iii) dopamine transporter in lymphocytes was evidenced in "gambler" vs "non-gambler" rats. | Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms.
Zoratto F, Romano E, Pascale E, Pucci M, Falconi A, Dell'Osso B, Maccarrone M, Laviola G, D'Addario C, Adriani W. | 11/11/2017 |
| Together these results support the hypothesis that sigma1R agonists promote dissociation of sigma1R multimers into monomers, which then interact with DAT to stabilize an outward-facing DAT conformation and enhance cocaine binding. | The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.
Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL., Free PMC Article | 07/15/2017 |
| The present study suggested that amphetamine-induced circling behavior indicated striatal dopaminergic alterations and that dopamine transporter (DAT) and dopamine D2 receptor binding could be key markers for predicting motor dysfunction after mild focal ischemia. | Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia.
Momosaki S, Ito M, Yamato H, Iimori H, Sumiyoshi H, Morimoto K, Imamoto N, Watabe T, Shimosegawa E, Hatazawa J, Abe K., Free PMC Article | 04/29/2017 |
| Increased expression of DAT is associated with visceral obesity | A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity.
Spadaro PA, Naug HL, DU Toit EF, Donner D, Colson NJ., Free PMC Article | 11/5/2016 |
| Data show that Fischer 344 rats displayed greater tyrosine hydroxylase and dopamine transporter levels in the frontal cortex compared to the Lewis rats. | Deficits in Sustained Attention and Changes in Dopaminergic Protein Levels following Exposure to Proton Radiation Are Related to Basal Dopaminergic Function.
Davis CM, DeCicco-Skinner KL, Hienz RD., Free PMC Article | 07/2/2016 |
| Study indicated that enhanced infralimbic DAT function is a consequence of adolescent social stress exposure | Increased dopamine transporter function as a mechanism for dopamine hypoactivity in the adult infralimbic medial prefrontal cortex following adolescent social stress.
Novick AM, Forster GL, Hassell JE, Davies DR, Scholl JL, Renner KJ, Watt MJ., Free PMC Article | 05/14/2016 |
| Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment. | Ctr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane.
De Gois S, Slama P, Pietrancosta N, Erdozain AM, Louis F, Bouvrais-Veret C, Daviet L, Giros B., Free PMC Article | 10/17/2015 |
| Data suggest that expression of Dat1 and Vmat2 (vesicular monoamine transporter 2) in dopaminergic neurons in striatum can be down-regulated by dietary factors (here, ingestion of acrylamide, a food contaminant created by heating starchy foods). | Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system.
Pan X, Guo X, Xiong F, Cheng G, Lu Q, Yan H. | 07/25/2015 |
| Comparative modeling and small molecule docking indicated that the tropane pharmacophore of RTI 82 was positioned in the central DA active site with an orientation that juxtaposed the aryliodoazide group for cross-linking to rat DAT Phe-319. | Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.
Dahal RA, Pramod AB, Sharma B, Krout D, Foster JD, Cha JH, Cao J, Newman AH, Lever JR, Vaughan RA, Henry LK., Free PMC Article | 02/14/2015 |