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    FSHB follicle stimulating hormone subunit beta [ Homo sapiens (human) ]

    Gene ID: 2488, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Implication of FSHB rs10835638 variant in endometriosis in Brazilian women.

    Implication of FSHB rs10835638 variant in endometriosis in Brazilian women.
    Bianco B, Loureiro FA, Trevisan CM, Christofolini DM, Laganà AS, Barbosa CP., Free PMC Article

    11/3/2023
    Spontaneous alterations in semen parameters are associated with age, accessory gland function and the FSHB c.-211G>T variant.

    Spontaneous alterations in semen parameters are associated with age, accessory gland function and the FSHB c.-211G>T variant.
    Zitzmann M, Schubert M, Sansone A, Kliesch S.

    09/25/2023
    Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis.

    Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis.
    Bianco B, Loureiro FA, Trevisan CM, Peluso C, Christofolini DM, Montagna E, Laganà AS, Barbosa CP., Free PMC Article

    04/30/2022
    A speech planning network for interactive language use.

    A speech planning network for interactive language use.
    Castellucci GA, Kovach CK, Howard MA 3rd, Greenlee JDW, Long MA., Free PMC Article

    03/12/2022
    FSHB Genotype Identified as a Relevant Diagnostic Parameter Revealed by Cluster Analysis of Men With Idiopathic Infertility.

    FSHB Genotype Identified as a Relevant Diagnostic Parameter Revealed by Cluster Analysis of Men With Idiopathic Infertility.
    Krenz H, Sansone A, Kliesch S, Gromoll J, Schubert M., Free PMC Article

    02/19/2022
    FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2020 men from the general Danish population.

    FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2020 men from the general Danish population.
    Bang AK, Almstrup K, Nordkap L, Priskorn L, Petersen JH, Blomberg Jensen M, Krause M, Holmboe SA, Egeberg Palme DL, Winge SB, Joensen UN, Olesen IA, Hvidman HW, Juul A, Rajpert-De Meyts E, Jørgensen N.

    11/6/2021
    Does the FSHB c.-211G>T polymorphism impact Sertoli cell number and the spermatogenic potential in infertile patients?

    Does the FSHB c.-211G>T polymorphism impact Sertoli cell number and the spermatogenic potential in infertile patients?
    Schubert M, Kaldewey S, Pérez Lanuza L, Krenz H, Dugas M, Berres S, Kliesch S, Wistuba J, Gromoll J.

    09/18/2021
    Role of FSH and FSH receptor on HUVECs migration.

    Role of FSH and FSH receptor on HUVECs migration.
    Tan D, Zhao Y, Ma D, Tong F.

    09/11/2021
    FSHB Transcription is Regulated by a Novel 5' Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism.

    FSHB  Transcription is Regulated by a Novel 5' Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism.
    Bohaczuk SC, Thackray VG, Shen J, Skowronska-Krawczyk D, Mellon PL., Free PMC Article

    05/15/2021
    Clinical and genetic analysis of an isolated follicle-stimulating hormone deficiency female patient.

    Clinical and genetic analysis of an isolated follicle-stimulating hormone deficiency female patient.
    Zhu L, Xiao N, Zhang T, Kong P, Xu B, Fang Z, Jin L., Free PMC Article

    02/6/2021
    Candidate genes for age at menarche are associated with endometrial hyperplasia.

    Candidate genes for age at menarche are associated with endometrial hyperplasia.
    Ponomarenko I, Reshetnikov E, Polonikov A, Sorokina I, Yermachenko A, Dvornyk V, Churnosov M.

    08/29/2020
    FSH concentrations in the follicular fluid are risk factors for aneuploidy pregnancies.

    Correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes.
    Liang L, Zhao XX.

    06/27/2020
    FSHB -211G>T was significantly associated with reduced chances of sperm retrieval in patients with unexplained azoospermia.

    FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia.
    Busch AS, Tüttelmann F, Cremers JF, Schubert M, Nordhoff V, Schüring AN, Zitzmann M, Gromoll J, Kliesch S.

    05/2/2020
    Follicle-stimulating hormone (FSH) primarily regulates granulosa cells and follicular growth in females, and Sertoli cell function in males.

    Commentary on the Recent FSH Collection: Known Knowns and Known Unknowns.
    Coss D., Free PMC Article

    02/15/2020
    nonsense mutation (c.343C > T:p. Arg115Stop) in exon 3 caused failure of onset of puberty

    FSH β-subunit mutations in two sisters: the first report from the Indian sub-continent and review of previous cases.
    Misgar RA, Wani AI, Bankura B, Bashir MI, Roy A, Das M.

    09/28/2019
    The wild-type allele G was found in 86.4% and the polymorphic allele T in 13.6% of the women respectively. Women carrying the GT genotype had a poorer response more frequently to controlled ovarian hyperstimulation when compared to individuals with the GG genotype, higher LH levels, lower AFC), oocytes retrieved and embryos.

    Effects of a Polymorphism in the Promoter Region of the Follicle-Stimulating Hormone Subunit Beta (FSHB) Gene on Female Reproductive Outcomes.
    Trevisan CM, de Oliveira R, Christofolini DM, Barbosa CP, Bianco B.

    03/16/2019
    We propose that like in men, also in women the FSHB -211 G>T represents a key genetic modulator of circulating gonadotropin, leading to various possible downstream effects on reproductive physiology.

    FSHB -211 G>T is a major genetic modulator of reproductive physiology and health in childbearing age women.
    Rull K, Grigorova M, Ehrenberg A, Vaas P, Sekavin A, Nõmmemees D, Adler M, Hanson E, Juhanson P, Laan M.

    02/2/2019
    High follicle stimulating hormone expression is associated with Turner syndrome.

    FSH may be a useful tool to allow early diagnosis of Turner syndrome.
    Carpini S, Carvalho AB, de Lemos-Marini SHV, Guerra-Junior G, Maciel-Guerra AT., Free PMC Article

    08/18/2018
    We found a genetic association between rs11031006 (FSHB) SNP and endometriosis. WNT4 and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.

    The role of gene polymorphisms in endometriosis.
    Matalliotakis M, Zervou MI, Matalliotaki C, Rahmioglu N, Koumantakis G, Kalogiannidis I, Prapas I, Zondervan K, Spandidos DA, Matalliotakis I, Goulielmos GN., Free PMC Article

    07/28/2018
    the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated.

    Evaluation of in vivo bioactivities of recombinant hypo- (FSH(21/18)) and fully- (FSH(24)) glycosylated human FSH glycoforms in Fshb null mice.
    Wang H, May J, Butnev V, Shuai B, May JV, Bousfield GR, Kumar TR., Free PMC Article

    11/11/2017
    Genetic variation affecting FSH production (FSHB c.-211G>T) was associated with age at pubertal onset, as assessed by testicular enlargement. The effect appeared further modified by coexistence of genetic variation affecting FSH sensitivity (FSHR c.-29G>A).

    Genetic Variation of Follicle-Stimulating Hormone Action Is Associated With Age at Testicular Growth in Boys.
    Busch AS, Hagen CP, Main KM, Pereira A, Corvalan C, Almstrup K, Mericq V, Juul A.

    09/16/2017
    A novel homozygous mutation in the FSHbeta gene (c.343C > T) identified in a male patient with isolated FSH deficiency and infertility.

    Novel FSHβ mutation in a male patient with isolated FSH deficiency and infertility.
    Zheng J, Mao J, Cui M, Liu Z, Wang X, Xiong S, Nie M, Wu X.

    08/12/2017
    Association of the FSHB 211G > T polymorphism with male infertility in Han-Chinese

    The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis.
    Wu Q, Zhang J, Zhu P, Jiang W, Liu S, Ni M, Zhang M, Li W, Zhou Q, Cui Y, Xia X., Free PMC Article

    08/12/2017
    Genetic variations of FSH signaling appear to determine the individual set point of the hypothalamic-pituitary-gonadal axis already early in life.

    Genetic Variations in FSH Action Affect Sex Hormone Levels and Breast Tissue Size in Infant Girls: A Pilot Study.
    Henriksen LS, Hagen CP, Assens M, Busch AS, Skakkebæk NE, Almstrup K, Main KM.

    07/1/2017
    Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency

    Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency.
    Stern E, Ruf-Zamojski F, Zalepa-King L, Pincas H, Choi SG, Peskin CS, Hayot F, Turgeon JL, Sealfon SC., Free PMC Article

    06/24/2017
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