| Neuroprotective Effects of Transferrin in Experimental Glaucoma Models. | Neuroprotective Effects of Transferrin in Experimental Glaucoma Models.
Youale J, Bigot K, Kodati B, Jaworski T, Fan Y, Nsiah NY, Pappenhagen N, Inman DM, Behar-Cohen F, Bordet T, Picard E., Free PMC Article | 11/19/2022 |
| Tf can be incorporated by all glial cells-i.e., microglia, astrocytes, and oligodendroglial precursor cell-and that, acting on microglial cells in vitro, Tf increases microglial proliferation rates and phagocytic capacity. | Transferrin Enhances Microglial Phagocytic Capacity.
Carden TR, Correale J, Pasquini JM, Pérez MJ. | 01/18/2020 |
| our data establish that blood TSAT exerts a critical role in experimental stroke-induced brain damage. In addition, our findings suggest that the protective effect of iron-free transferrin (apotransferrin, ATf) at the neuronal level resides in preventing NMDA-induced HTf uptake and ROS production, which in turn reduces neuronal damage | Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.
DeGregorio-Rocasolano N, Martí-Sistac O, Ponce J, Castelló-Ruiz M, Millán M, Guirao V, García-Yébenes I, Salom JB, Ramos-Cabrer P, Alborch E, Lizasoain I, Castillo J, Dávalos A, Gasull T., Free PMC Article | 10/13/2018 |
| In brain interstitial fluid, transferrin-bound iron and non-transferrin-bound iron (NTBI) exist as potential iron sources | Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons.
Ji C, Kosman DJ., Free PMC Article | 06/27/2015 |
| Transferrin and thyroid hormone converge to regulate oligodendrocyte maturation and myelinogenesis. | Transferrin and thyroid hormone converge in the control of myelinogenesis.
Marziali LN, Garcia CI, Pasquini JM. | 05/2/2015 |
| This evidence supports a key role of Tf on the generation of oligodendrocytes (OLs) from Neural stem and progenitor cells (NSC/NPCs)and highlights its potential in demyelinating disorder treatment. | ApoTransferrin: dual role on adult subventricular zone-derived neurospheres.
Silvestroff L, Franco PG, Pasquini JM., Free PMC Article | 11/24/2012 |
| The ceruloplasmin/transferrin ratio tended to be higher in (jugular vein) plasma of nerve-injured rats as compared to controls. | The oxidative response in the chronic constriction injury model of neuropathic pain.
Tan EC, Bahrami S, Kozlov AV, Kurvers HA, Ter Laak HJ, Nohl H, Redl H, Goris RJ. | 01/21/2010 |
| we have discovered a novel mitochondrial iron transport system that goes awry in Parkinson's disease, and which may provide a new target for therapeutic intervention. | A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
Mastroberardino PG, Hoffman EK, Horowitz MP, Betarbet R, Taylor G, Cheng D, Na HM, Gutekunst CA, Gearing M, Trojanowski JQ, Anderson M, Chu CT, Peng J, Greenamyre JT., Free PMC Article | 01/21/2010 |
| synthesis and secretion of transferrin in rat parotid acinar cells | Transferrin secretory pathways in rat parotid acinar cells.
Nashida T, Yoshie S, Imai A, Shimomura H. | 01/21/2010 |
| Apotransferrin added to oligodendroglial cell cultures can correct the effects of iron deficiency. | Effect of transferrin on hypomyelination induced by iron deficiency.
Badaracco ME, Ortiz EH, Soto EF, Connor J, Pasquini JM. | 01/21/2010 |
| serotransferrin levels were increased in diestrous as compared with proestrous, estrous, metestrous | Hippocampal levels of gamma-enolase, C-1-tetrahydrofolate synthase and serotransferrin fluctuate over the estrous cycle in the rat.
Diao WF, Afjehi-Sadat L, Chen WQ, Höger J, Höger H, Pollak A, Lubec G. | 01/21/2010 |
| Plays role in maturation of Schwann cells(SC) in physiological conditions as well as in role in facilitating clearance of myelin debris and subsequent nerve regeneration and/or in SC phenotypic change, which led to survival after peripheral nerve injury. | The mRNA of transferrin is expressed in Schwann cells during their maturation and after nerve injury.
Salis C, Setton CP, Soto EF, Pasquini JM. | 01/21/2010 |
| in addition to hemoglobin-bound iron, Tf-bound iron may contribute to intracerebral hemorrhage-induced brain injury and thrombin may contribute to the latter by facilitating cellular iron uptake | Holo-transferrin and thrombin can interact to cause brain damage.
Nakamura T, Xi G, Park JW, Hua Y, Hoff JT, Keep RF. | 01/21/2010 |
| compared to transferrin, soluble melanotransferrin plays little or no role in Fe supply to the brain and erythropoietic tissue | The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain.
Richardson DR, Morgan EH. | 01/21/2010 |
| Transferrin is involved in the uptake of the radiopharmaceutical gallium-67 (67Ga) by regenerating liver tissue following partial hepatectomy but is not involved in the entry of 67Ga into hepatocytes. | Transferrin is not involved in the entry of 67Ga into hepatocytes from regenerating liver of partially hepatectomized rats.
Abe S, Hasegawa S, Nirasawa M, Sasaki M, Ohkubo Y. | 01/21/2010 |
| Our studies suggest that AEC I is not just a simple barrier for gas exchange, but a functional cell that protects alveolar epithelium from injury. | Alveolar type I cells protect rat lung epithelium from oxidative injury.
Chen J, Chen Z, Chintagari NR, Bhaskaran M, Jin N, Narasaraju T, Liu L., Free PMC Article | 01/21/2010 |
| effects of apotransferrin occur early in development during a narrow, transient "temporal window" within which oligodendroglia are sensitive to its action. | Differential effects of apotransferrin on two populations of oligodendroglial cells.
García CI, Paez P, Soto EF, Pasquini JM. | 01/21/2010 |
| data show that brain cells have the capacity to maintain minimum iron levels during iron deficiency which may be associated with increased iron-Tf uptake, stabilization of TfR mRNA, or increased Tf mRNA translation efficiency in specific cell types | Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats.
Han J, Day JR, Connor JR, Beard JL. | 01/21/2010 |
| first report describing presence of serotransferrin precursor protein homolog belonging to transferrin family and sharing epitopes with melanotransferrin in adrenal, its induction by ACTH, and sensitivity to ginkgolide B (adrenotransferrin). | Identification of the adrenocorticotropin and ginkgolide B-regulated 90-kilodalton protein (p90) in adrenocortical cells as a serotransferrin precursor protein homolog (adrenotransferrin).
Amri H, Li W, Drieu K, Papadopoulos V. | 01/21/2010 |