| Study suggested that somatostatin and nNOS are expressed in most interneurons whereas CB1 receptor is present in both interneurons and projection neurons in hippocampal regions | Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus.
Zou S, Kumar U. | 06/4/2016 |
| Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells. | Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.
Elrick MM, Samson WK, Corbett JA, Salvatori AS, Stein LM, Kolar GR, Naatz A, Yosten GL., Free PMC Article | 05/7/2016 |
| Results suggest that somatostatin suppresses GABA release from the amacrine cells by inhibiting presynaptic Ca2+ channels, in part through activating sst5/sst2 receptors, a process that is mediated by the intracellular cAMP-PKA signaling pathway | Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells.
Chen W, Ke JB, Wu HJ, Miao Y, Li F, Yang XL, Wang Z. | 02/14/2015 |
| These results suggest that a local release of somatostatin facilitates the excitability of trigeminal nocicepitve C1 neuronal activity via inhibition of GABAergic neurons | Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons.
Takahashi M, Takeda M, Matsumoto S. | 08/23/2014 |
| when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from beta-arrestins | Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons.
Zhao P, Canals M, Murphy JE, Klingler D, Eriksson EM, Pelayo JC, Hardt M, Bunnett NW, Poole DP., Free PMC Article | 02/8/2014 |
| The aim of this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia. | The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia.
Jovanović AA, Babović SS, Damjanović A, Puskas L, Lazić D, Cvetić T, Jasović-Gasić M. | 01/18/2014 |
| Helicobacter pylori is capable of inhibiting acid secretion directly as well as indirectly by activating intramural CGRP sensory neurons coupled to stimulation of SST and inhibition of histamine secretion. | H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion.
Zaki M, Coudron PE, McCuen RW, Harrington L, Chu S, Schubert ML. | 06/22/2013 |
| Data suggest that neuronostatin action to reduce food intake and water intake is mediated through melanocortin 3/4 receptors, not through oxytocin receptors. | The melanocortins, not oxytocin, mediate the anorexigenic and antidipsogenic effects of neuronostatin.
Yosten GL, Samson WK., Free PMC Article | 02/11/2013 |
| both ferret odor exposure and elevated plus maze exposure resulted in increased somatostatin | Comparison of the activation of somatostatin- and neuropeptide Y-containing neuronal populations of the rat amygdala following two different anxiogenic stressors.
Butler RK, White LC, Frederick-Duus D, Kaigler KF, Fadel JR, Wilson MA., Free PMC Article | 12/8/2012 |
| This study provides structural evidence that SST immunoreactivity in the pre-BotC is highly expressed in somas, terminals, and primary dendrites, and overlapped with small fusiform NK1R-ir neurons. | Synaptic relationship between somatostatin- and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats.
Wei XY, Zhao Y, Wong-Riley MT, Ju G, Liu YY. | 11/3/2012 |
| Surviving somatostatin interneurons display increased mRNA levels at late intervals (3 months) after kainic acid-induced epilepsy. | Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy.
Drexel M, Kirchmair E, Wieselthaler-Hölzl A, Preidt AP, Sperk G., Free PMC Article | 05/12/2012 |
| Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival. | Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival.
Vainio L, Perjes A, Ryti N, Magga J, Alakoski T, Serpi R, Kaikkonen L, Piuhola J, Szokodi I, Ruskoaho H, Kerkelä R., Free PMC Article | 04/21/2012 |
| These findings suggest that somatostatin directly inhibits the activity of rat GnRH neurons through volume transmission in the organum vasculosum of the lamina terminalis region. | Somatostatin inhibition of GnRH neuronal activity and the morphological relationship between GnRH and somatostatin neurons in rats.
Koyama M, Yin C, Ishii H, Sakuma Y, Kato M. | 03/31/2012 |
| 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in the water-immersion restraint stressed rats | Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats.
Li Y, Li XF, Hua Guo, Xu JD, Zhang XH, Li LS, Feng XY, Zhang Y, Duan ZP, Zhu JX. | 06/18/2011 |
| Pancreatic islet CCK1/2 receptors initiate somatosatin secretion through constitutive secretion controlled at the level of protein synthesis. | Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.
El-Kouhen K, Morisset J. | 05/31/2010 |
| These results provide evidence that somatostatin tonically inhibits the peripheral nerve terminals of small-diameter cutaneous afferent fibers. | Tonic inhibition of somatostatin on C and Adelta afferent fibers in rat dorsal skin in vivo.
Wang J, Guo Y, Cao DY, Luo R, Ma SJ, Wang HS, Pickar JG, Zhao Y. | 01/21/2010 |
| Somatostatin has no effect on basal and IL-1beta-stimulated PGE(2) release, whereas cortistatin reduced baseline prostanoids production and abolished stimulation elicited by IL-1beta. | Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes.
Dello Russo C, Lisi L, Navarra P, Tringali G. | 01/21/2010 |
| Somatostatin secretion in perfused rat pancreas by obestatin | Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas.
Egido EM, Hernández R, Marco J, Silvestre RA. | 01/21/2010 |
| Release of regulatory gut peptides somatostatin, by acid and hyperosmolal solutions in the intestine in conscious rats | Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats.
Rudholm T, Wallin B, Theodorsson E, Näslund E, Hellström PM. | 01/21/2010 |
| These data support involvement of SRIF2B (SSTR4) receptors in the negative contractile effects of SRIF-14, while one or more of the three SRIF1 receptor subtypes (SSTR2, 3 or 5) may contribute to the positive contractile effects of SRIF-14. | SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes.
Bell D, Zhao Y, McMaster B, McHenry EM, Wang X, Kelso EJ, McDermott BJ. | 01/21/2010 |
| SST-14 was cointernalized with SSTR3, was uncoupled from receptor, & was sorted into an endocytic degradation pathway, whereas octreotide was recycled as an intact peptide. Chronic stimulation of SSTR3 induced time-dependent downregulation of receptor. | Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells.
Roosterman D, Brune NE, Kreuzer OJ, Feld M, Pauser S, Zarse K, Steinhoff M, Meyerhof W. | 01/21/2010 |
| Taken together, these results provide first evidence that the presence of SST is a unique feature for the selective sparing of medium sized aspiny interneurons in excitotoxicity. | Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicity.
Kumar U. | 01/21/2010 |
| Inhibitory effect of Sst on prostaglandin E2 synthesis by primary neonatal rat glial cells is reported. | Inhibitory effect of somatostatin on prostaglandin E2 synthesis by primary neonatal rat glial cells.
Dror N, Tveria L, Meniv I, Ben-Shmuel S, Filipovich T, Fleisher-Berkovich S. | 01/21/2010 |
| Endogenously released somatostatin may induce slow inhibitory postsynaptic currents through the activation of GIRK channels in substantia gelatinosa neurons; this slow synaptic transmission might play an important role in spinal antinociception. | Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin.
Nakatsuka T, Fujita T, Inoue K, Kumamoto E., Free PMC Article | 01/21/2010 |
| Data show that SOM neurons in the claustrum do not reveal any significant changes in their numerical density during the postnatal period. | NPY-, SOM- and VIP-containing interneurons in postnatal development of the rat claustrum.
Kowiański P, Moryś JM, Dziewiatkowski J, Wójcik S, Sidor-Kaczmarek J, Moryś J. | 01/21/2010 |