| Structure of the bile acid transporter and HBV receptor NTCP. | Structure of the bile acid transporter and HBV receptor NTCP.
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. | 07/9/2022 |
| The present study suggests that glycochenodeoxycholate triggers the retrieval of Ntcp from the basolateral membrane into the cytosol through an oxidative stress-dependent activation of Fyn. | Regulation of Plasma Membrane Localization of the Na⁺-Taurocholate Co-Transporting Polypeptide by Glycochenodeoxycholate and Tauroursodeoxycholate.
Mayer PGK, Qvartskhava N, Sommerfeld A, Görg B, Häussinger D. | 06/23/2019 |
| Administration of glucocorticoids (GCs) enhanced liver bile acid uptake by increasing the expression of the major hepatocyte basolateral bile transporter (Ntcp)in rats. The reduced expression of a bile acid synthesis rate-controlling enzyme, Cyp7a1, suggests that treatment with GCs suppressed hepatic bile acid synthesis. | Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts.
Xiao Y, Yan W, Zhou K, Cao Y, Cai W. | 06/24/2017 |
| Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate | Regulation of plasma membrane localization of the Na+-taurocholate cotransporting polypeptide (Ntcp) by hyperosmolarity and tauroursodeoxycholate.
Sommerfeld A, Mayer PG, Cantore M, Häussinger D., Free PMC Article | 01/16/2016 |
| Taurocholate (TCA) for Ntcp. | Age-dependent activity of the uptake transporters Ntcp and Oatp1b2 in male rat hepatocytes: from birth till adulthood.
Fattah S, Augustijns P, Annaert P. | 07/25/2015 |
| This study identified a motif which is critical for Ntcp plasma membrane localization. | A dileucine motif is involved in plasma membrane expression and endocytosis of rat sodium taurocholate cotransporting polypeptide (Ntcp).
Stross C, Kluge S, Weissenberger K, Winands E, Häussinger D, Kubitz R. | 01/11/2014 |
| hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis | The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis.
Cherrington NJ, Estrada TE, Frisk HA, Canet MJ, Hardwick RN, Dvorak B, Lux K, Halpern MD., Free PMC Article | 02/23/2013 |
| sustained repression and translocation of Ntcp and the expression of Mrp4 at the basolateral membrane seem to be responsible for the high blood bile acids levels after massive hepatectomy | Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy.
Miura T, Kimura N, Yamada T, Shimizu T, Nanashima N, Yamana D, Hakamada K, Tsuchida S. | 11/26/2011 |
| Ca(2+)-dependent PKCs induce vesicular retrieval of Ntcp, thereby reducing bile salt uptake. Short-term downregulation of Ntcp by endocytosis may be important mechanism to protect hepatocytes from effects of toxic intracellular bile salt concentrations. | Protein kinase C induces endocytosis of the sodium taurocholate cotransporting polypeptide.
Stross C, Helmer A, Weissenberger K, Görg B, Keitel V, Häussinger D, Kubitz R. | 09/6/2010 |
| Report PKCepsilon-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. | PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line.
Schonhoff CM, Yamazaki A, Hohenester S, Webster CR, Bouscarel B, Anwer MS., Free PMC Article | 01/21/2010 |
| In conclusion, zonal downregulation of Bsep in obstructive cholestasis is associated with portal inflammation and is mediated by TNF-alpha and IL-1beta. | Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2.
Donner MG, Schumacher S, Warskulat U, Heinemann J, Häussinger D. | 01/21/2010 |
| Upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. | Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.
Dietrich CG, Martin IV, Porn AC, Voigt S, Gartung C, Trautwein C, Geier A. | 01/21/2010 |
| In hypoxic liver tissue, a marked reduction in the mRNA levels of Na(+)-taurocholate-cotransporting polypeptide (Ntcp was detected before bile duct proliferation occurred | Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes.
Fouassier L, Beaussier M, Schiffer E, Rey C, Barbu V, Mergey M, Wendum D, Callard P, Scoazec JY, Lasnier E, Stieger B, Lienhart A, Housset C. | 01/21/2010 |
| Results show that loop amino acids are required for sodium-dependent substrate translocation by the sodium-dependent taurocholate cotransporting polypeptide Ntcp. | Transport of taurocholate by mutants of negatively charged amino acids, cysteines, and threonines of the rat liver sodium-dependent taurocholate cotransporting polypeptide Ntcp.
Zahner D, Eckhardt U, Petzinger E. | 01/21/2010 |
| Substrate specificity of ntcp is considerably broader than previously suspected and caution extrapolation of transport data obtained in vitro to physiological function in vivo. | Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake.
Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW. | 01/21/2010 |
| pituitary hormones play an essential role in the sexually dimorphic control of Ntcp expression in adult rat liver and in the mediation of estrogen effects. | Multihormonal regulation of hepatic sinusoidal Ntcp gene expression.
Simon FR, Fortune J, Iwahashi M, Qadri I, Sutherland E. | 01/21/2010 |
| Physiological significance of cross-talk between ERalpha and Stat5a in liver, in which both proteins are expressed. Novel mechanism by which expression of ntcp, an important hepatic bile acid transporter, can be regulated by multiple hormones. | Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a.
Cao J, Wood M, Liu Y, Hoffman T, Hyde J, Park-Sarge OK, Vore M. | 01/21/2010 |
| Pregnancy is associated with reduced Ntcp expression and function in the rat | Down-regulation of the Na+/taurocholate cotransporting polypeptide during pregnancy in the rat.
Arrese M, Trauner M, Ananthanarayanan M, Pizarro M, Solís N, Accatino L, Soroka C, Boyer JL, Karpen SJ, Miquel JF, Suchy FJ. | 01/21/2010 |
| Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner. Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression. | Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene.
Jung D, Hagenbuch B, Fried M, Meier PJ, Kullak-Ublick GA. | 01/21/2010 |
| Results suggest that the Ser-226 in the third cytoplasmic loop of Ntcp is phosphorylated and cAMP may increase Ntcp translocation to the cell membrane by dephosphorylating Ntcp at this site. | Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp.
Anwer MS, Gillin H, Mukhopadhyay S, Balasubramaniyan N, Suchy FJ, Ananthanarayanan M. | 01/21/2010 |
| Data show that endogenous thyroxine but not corticosterone regulates the developmentally timed appearance of the apical sodium-dependent bile acid transporter. | Ontogenetic development of rat intestinal bile acid transport requires thyroxine but not corticosterone.
Monteiro I, David ES, Ferraris RP. | 01/21/2010 |
| analysis of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter | Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter.
Sun AQ, Balasubramaniyan N, Chen H, Shahid M, Suchy FJ. | 01/21/2010 |
| TNF-alpha represents the master cytokine responsible for HNF1-dependent down-regulation of Ntcp in CCl(4)-induced toxic liver injury and IL-1 beta predominates in a complex signaling network of Ntcp regulation in cholestatic liver injury | Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C. | 01/21/2010 |
| translocation requires activation of protein kinase B | Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation.
Webster CR, Srinivasulu U, Ananthanarayanan M, Suchy FJ, Anwer MS. | 01/21/2010 |