| The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung. | The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.
Roeder F, Knudsen L, Schmiedl A., Free PMC Article | 03/19/2024 |
| Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production. | Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production.
Wang Q, Wang Q, Zhao Z, Fan J, Qin L, Alexander DB, Tsuda H, Zhao D, Xu J., Free PMC Article | 02/12/2022 |
| Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report. | Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.
Ran R, Cai D, King SD, Que X, Bath JM, Chen SY., Free PMC Article | 06/5/2021 |
| SP-A expression was up-regulated in the middle ear effusion of non-typeable Haemophilus influenza otitis media. | Expression of surfactant Protein-A in the Haemophilus influenzae-induced otitis media in a rat model.
Yu GH, Kim HB, Ko SH, Kim YW, Lim YS, Park SW, Cho CG, Park JH. | 11/17/2018 |
| SPA binds dipalmitoyl-phosphatidylcholine, the major surfactant lipid component, but not phosphatidylinositol; SPD exhibits the opposite preference. Data suggest flexibility in a key surface loop supports distinctive lipid binding of SPA; quadruple mutant SPA (E171D/P175E/R197N/K203D) that introduces SPD-like loop-stabilizing Ca2+ binding site in carbohydrate recognition domain exhibits ligand-binding preferences of SPD. | Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop.
Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. | 08/19/2017 |
| Downregulation of SP-A expression caused due to silica is an important factor in the occurrence and development of silicosis. | Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.
Liu N, Xue L, Guan Y, Li QZ, Cao FY, Pang SL, Guan WJ. | 07/1/2017 |
| Liraglutide activates the GLP1 receptor, increasing ACE2 expression, reversing right ventricle hypertrophy, and improving the production of SP-A and SP-B in the lungs of Type 1 Diabetes rats | Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats.
Romaní-Pérez M, Outeiriño-Iglesias V, Moya CM, Santisteban P, González-Matías LC, Vigo E, Mallo F. | 12/19/2015 |
| Mutations of rat surfactant protein A have distinct effects on its glycosylation, secretion, aggregation and degradation. | Mutations of rat surfactant protein A have distinct effects on its glycosylation, secretion, aggregation and degradation.
Yang W, Shen H, Fang G, Li H, Li L, Deng F, Gu W, Li K, Ma L, Gu J, Wang Y. | 01/31/2015 |
| Dual positive effects of leptin were found on protein expression and transcriptional activity of thyroid transcription factor-1 | Leptin promotes fetal lung maturity and upregulates SP-A expression in pulmonary alveoli type-II epithelial cells involving TTF-1 activation.
Chen H, Zhang JP, Huang H, Wang ZH, Cheng R, Cai WB., Free PMC Article | 03/1/2014 |
| VIP can up-regulate the expression of SP-A in alveolar type II cells. | [Influence of vasoactive intestinal peptide on expression of pulmonary surfactant associated protein A in lung explants].
Li L, Luo ZQ, Wu GQ, Sun XH. | 12/22/2012 |
| NG-nitro-L-arginine can protect the lung from LPS-induced injury by up-regulating the expression of PS. | [Effect of NG-nitro-L-arginine on pulmonary surfactant and pulmonary apoptosis in acute lung injury induced by lipopolysaccharide].
Li LP, Zhang JX, Li LF. | 08/20/2011 |
| A novel role is demonstrated for SP-A in modulating endolysosomal trafficking via Rab7b (but not Rab5 nor Rab11) in primary alveolar macrophages, and the biochemical pathways are defined. | Pulmonary surfactant protein A enhances endolysosomal trafficking in alveolar macrophages through regulation of Rab7.
Sender V, Moulakakis C, Stamme C. | 04/30/2011 |
| SP-A stimulates the release of neutrophil chemotactic factor by alveolar type II cells, and this effect is mediated by the receptor for SP-A specifically expressed by these cells. | Surfactant protein A stimulates release of neutrophil chemotactic factors by alveolar type II pneumocytes.
Kresch MJ, Block M, Karim MR, Zhu L, Hussain N, Thrall RS, Sha'afi RI. | 03/26/2011 |
| VIP elevated SP-A expression in ATII cells which was mediated by enhanced sp-a gene transcription | Vasoactive intestinal peptide induces surfactant protein A expression in ATII cells through activation of PKC/c-Fos pathway.
Li L, She H, Yue S, Feng D, Luo Z. | 02/26/2011 |
| crystal structures of calcium-dependent complexes of the C-terminal neck and carbohydrate recognition domain of SP-A with carbohydrates | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA., Free PMC Article | 02/5/2011 |
| The SPA level decreases significantly in acute pulmonary embolism. | [The change of pulmonary surfactant associated protein A in acute pulmonary embolism].
Liu CP, Zhang YJ, Lu WX, Ji YQ, Zhang WH, Wang C. | 09/6/2010 |
| Data suggest that the pathway for secretion of newly synthesized surfactant protein-A is by transfer from the site of synthesis to the storage/secretory organelle prior to lamellar body exocytosis. | Pathway to lamellar bodies for surfactant protein A.
Fisher AB, Dodia C, Ruckert P, Tao JQ, Bates SR., Free PMC Article | 07/12/2010 |
| After OVA challenge alveolar epithelial cells Type II (AEII) show a significantly higher expression of SP-A and SP-D leading also to higher amounts of both SPs in BALF, and macrophages gather predominantly SP-A. | Increased surfactant protein a and d expression in acute ovalbumin-induced allergic airway inflammation in brown norway rats.
Schmiedl A, Lührmann A, Pabst R, Koslowski R. | 01/21/2010 |
| cigarette smoke alone decreases the level of SP-A and that might have an important effect on surfactant metabolism and the host defense functions of surfactant in the peripheral airways | The alteration and significance of surfactant protein A in rats chronically exposed to cigarette smoke.
Hu Q, Zhang H, Xiong S, Shi X, Xu Y, Zhang Z, Zhen G, Zhao J. | 01/21/2010 |
| alterations of surfactant are a consequence of the ventilation strategy that impair the biophysical activity of this material and thereby contribute directly to lung dysfunction over time | Alterations to surfactant precede physiological deterioration during high tidal volume ventilation.
Maruscak AA, Vockeroth DW, Girardi B, Sheikh T, Possmayer F, Lewis JF, Veldhuizen RA. | 01/21/2010 |
| Results suggest that there is no primary deficiency of surfactant proteins A, B, or C in the nitrofen-induced rat model of congenital diaphragmatic hernia. | Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model.
Van Tuyl M, Blommaart Pj, Keijzer R, Wert SE, Ruijter J, Lamers WH, Tibboel D. | 01/21/2010 |
| We suggest that enhanced release of surfactant phospholipids and SP-A represents an early protective response that compensates in part for the inactivation of intraalveolar surfactant in the early phase of IR injury. | Improved lung preservation relates to an increase in tubular myelin-associated surfactant protein A.
Fehrenbach H, Tews S, Fehrenbach A, Ochs M, Wittwer T, Wahlers T, Richter J., Free PMC Article | 01/21/2010 |
| SP-A selectively enhances mannose receptor expression on monocyte-derived macrophages, a process involving both the attached sugars and collagen-like domain of SP-A. | Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages.
Beharka AA, Gaynor CD, Kang BK, Voelker DR, McCormack FX, Schlesinger LS. | 01/21/2010 |
| Direct effect of SFTPA1 on rat myometrial cells and inhibitory cross talk between SFTPA1 and LPS signals. | Direct interaction of surfactant protein A with myometrial binding sites: signaling and modulation by bacterial lipopolysaccharide.
Garcia-Verdugo I, Leiber D, Robin P, Billon-Denis E, Chaby R, Tanfin Z. | 01/21/2010 |
| SP-A and Prdx6 directly interact, which provides a mechanism for regulation of the PLA(2) activity of Prdx6 by SP-A | Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity.
Wu YZ, Manevich Y, Baldwin JL, Dodia C, Yu K, Feinstein SI, Fisher AB. | 01/21/2010 |