| Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway. | Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway.
Zhu P, Wu X, Ni L, Chen K, Dong Z, Du J, Kong F, Mao Y, Tao H, Chu M, Mao H, Yang H, Liu Q, Gan M, Geng D. | 11/16/2023 |
| HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. | HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
Lei L, Feng J, Wu G, Wei Z, Wang JZ, Zhang B, Liu R, Liu F, Wang X, Li HL., Free PMC Article | 01/11/2023 |
| Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system. | Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system.
Storman EM, Liu NJ, Gintzler AR., Free PMC Article | 04/30/2022 |
| Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A. | Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A.
Lan J, Zhong Z, Wang Y, Xiong Y, Ye Q., Free PMC Article | 10/10/2020 |
| PP2A is a target of piperine, which induces autophagy in a rotenone-induced Parkinson's disease model | Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model.
Liu J, Chen M, Wang X, Wang Y, Duan C, Gao G, Lu L, Wu X, Wang X, Yang H., Free PMC Article | 03/24/2018 |
| Reduction of protein phosphatase-2A (PP2A) activity is a common clinical feature of Alzheimer's disease and vascular dementia. | Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion.
Liu CD, Wang Q, Zong DK, Pei SC, Yan Y, Yan ML, Sun LL, Hao YY, Mao M, Xing WJ, Ren H, Ai J. | 10/21/2017 |
| STRN4 is preferentially expressed in mushroom spines, and STRN4 specifically maintains mushroom spines but not thin spines and filopodia through interaction with the phosphatase PP2A | Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.
Lin L, Lo LH, Lyu Q, Lai KO., Free PMC Article | 06/24/2017 |
| Melatonin -exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons. | Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription.
Lin TB, Hsieh MC, Lai CY, Cheng JK, Wang HH, Chau YP, Chen GD, Peng HY. | 12/17/2016 |
| that loss of glucocerebrosidase function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation | GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.
Du TT, Wang L, Duan CL, Lu LL, Zhang JL, Gao G, Qiu XB, Wang XM, Yang H., Free PMC Article | 09/17/2016 |
| Andrographolide activates the PP2A-p38MAPK-p53-Bax cascade. | Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade.
Chen YY, Hsieh CY, Jayakumar T, Lin KH, Chou DS, Lu WJ, Hsu MJ, Sheu JR., Free PMC Article | 10/31/2015 |
| We discovered that PP-2A was capable of regulating the Abeta level by regulating APP phosphorylation level and beta and gamma-secretase activity | Mechanism of protein phosphatase-2Aregulating phosphorylation of amyloid precursor proteosome and Aβ generation.
Zhang JW, Jing LJ, Jian G, Dong GC. | 07/4/2015 |
| findings provide new insight into how CA may improve glucose homeostasis through enhancing peripheral glucose clearance in tissues such as skeletal muscle through a PME-1/PP2A/PKB signalling axis | Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis.
Lipina C, Hundal HS. | 05/16/2015 |
| PP2AC translocation to the particulate fraction occurs through a GiPCR-Gbetagamma-PI3K mediated intracellular signalling pathway, which may involve elevated PP2AC carboxylmethylation at leu309. | Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes.
Longman MR, Ranieri A, Avkiran M, Snabaitis AK., Free PMC Article | 11/22/2014 |
| beta-N-methylamino-l-alanine leads to tau pathology by inhibiting PP2A through the activation of mGluR5, the consequent release of PP2Ac from the mGluR5-PP2A complex, and its phosphorylation at Tyr(307) by Src | Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam.
Arif M, Kazim SF, Grundke-Iqbal I, Garruto RM, Iqbal K., Free PMC Article | 03/29/2014 |
| Only the B55alpha(55-kDa regulatory subunit, alpha isoform) regulatory subunit of PP2A was able to bind retinoblastoma-like 1 (p107), and this interaction was induced by fibroblast growth factor 1 in chondrocytes but not in other cell types. | The B55α regulatory subunit of protein phosphatase 2A mediates fibroblast growth factor-induced p107 dephosphorylation and growth arrest in chondrocytes.
Kolupaeva V, Daempfling L, Basilico C., Free PMC Article | 09/21/2013 |
| Blockade of PP2A via gene silencing techniques inhibited autophagy and caused intracellular accumulation of ubiquitinated proteins in rat neuronal culture. | PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.
Magnaudeix A, Wilson CM, Page G, Bauvy C, Codogno P, Lévêque P, Labrousse F, Corre-Delage M, Yardin C, Terro F. | 05/25/2013 |
| PP2A is inactivated by zinc via Src dependent phosphorylation at tyrosine 307. | Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.
Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R, Wang JZ. | 05/25/2013 |
| Abeta(25-35) and ginsenoside Rb1 can regulate the expressions of GSK-3beta, CDK-5 and PP2A in differentiated neural stem cells. | [Abeta(25-35) and ginsenoside Rb1 influence on the expression of GSK-3beta, CDK-5 and PP2A in differentiated neural stem cells of rats].
Zhao QX, Yan WH, Han XF, Xu Y, Xing Y. | 02/2/2013 |
| our results suggest that Asp664 cleavage of APP leads to tau hyperphosphorylation at specific epitopes by modulating PP2A activity | Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity.
Park SS, Jung HJ, Kim YJ, Park TK, Kim C, Choi H, Mook-Jung IH, Koo EH, Park SA. | 01/12/2013 |
| PP2A can be a novel target for future therapies aiming to protect beta-cells mass in the late transitional phase of non-insulin dependent type 2 diabetes (NIDDM). | Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription.
Cho IS, Jung M, Kwon KS, Moon E, Cho JH, Yoon KH, Kim JW, Lee YD, Kim SS, Suh-Kim H., Free PMC Article | 08/11/2012 |
| PP2A inhibits association between the Na+,K+-ATPase and arrestin, and diminishes the effect of arrestin on Na+,K+-ATPase trafficking. | Protein phosphatase 2A interacts with the Na,K-ATPase and modulates its trafficking by inhibition of its association with arrestin.
Kimura T, Han W, Pagel P, Nairn AC, Caplan MJ., Free PMC Article | 05/12/2012 |
| analysis of resistance of Akt kinase and PP2A to dephosphorylation through ATP-dependent conformational plasticity | Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.
Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM., Free PMC Article | 01/28/2012 |
| Superoxide, PKC-zeta, and PP2A are involved in the hypoxia-induced increase in electrical conductance and occludin reduction at the plasma membrane in alveolar epithelial cells. | Hypoxia increases transepithelial electrical conductance and reduces occludin at the plasma membrane in alveolar epithelial cells via PKC-ζ and PP2A pathway.
Caraballo JC, Yshii C, Butti ML, Westphal W, Borcherding JA, Allamargot C, Comellas AP., Free PMC Article | 09/17/2011 |
| These findings establish the presence of potentially regulatory and redox-active PAO-binding vicinal thiols on the catalytic subunit of PP2A and suggest that a population of PP2Ac may contain disulfide bonds in vivo. | Phenylarsine oxide binding reveals redox-active and potential regulatory vicinal thiols on the catalytic subunit of protein phosphatase 2A.
Foley TD, Melideo SL, Healey AE, Lucas EJ, Koval JA., Free PMC Article | 04/30/2011 |
| JC virus tAg contributes significantly to viral DNA replication in vivo; binds Rb proteins and PP2A. | JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.
Bollag B, Hofstetter CA, Reviriego-Mendoza MM, Frisque RJ., Free PMC Article | 09/13/2010 |