| These results suggest that increased PNMT gene expression via altered transcriptional activity is a possible mechanism by which prenatal exposure to elevated levels of glucocorticoids may program for hypertension later in life. | Prenatal glucocorticoid exposure programs adrenal PNMT expression and adult hypertension.
Nguyen P, Khurana S, Peltsch H, Grandbois J, Eibl J, Crispo J, Ansell D, Tai TC. | 01/30/2016 |
| Stress elevated PNMT levels in heart ventricles. | Regulation of catecholamine-synthesising enzymes and beta-adrenoceptors gene expression in ventricles of stressed rats.
Spasojevic N, Gavrilovic L, Dronjak S. | 02/11/2012 |
| Findings demonstrate that CoCl(2)-induced ROS have synergistic effects on hormonal and neural activation of the PNMT promoter. | Role of reactive oxygen species in the neural and hormonal regulation of the PNMT gene in PC12 cells.
Crispo JA, Ansell DR, Ubriaco G, Tai TC., Free PMC Article | 02/4/2012 |
| Altered transcriptional regulation of PNMT is a contributing factor to altered adrenergic function in hypertension. | Regulation of the phenylethanolamine N-methyltransferase gene in the adrenal gland of the spontaneous hypertensive rat.
Nguyen P, Peltsch H, de Wit J, Crispo J, Ubriaco G, Eibl J, Tai TC. | 01/21/2010 |
| In chronically isolated rats, gene expression levels of phenylethanolamine N-methyltransferase in the adrenal medulla was decreased. | Chronic isolation of adult rats decreases gene expression of catecholamine biosynthetic enzymes in adrenal medulla.
Gavrilovic L, Spasojevic N, Tanic N, Dronjak S. | 01/21/2010 |
| Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. | Expression levels of mRNAs for catecholamine biosynthetic enzymes as markers of acute response to contusion stress during the early postmortem period.
Takahashi S. | 01/21/2010 |
| Data show that voluntary wheel running failed to modify sensitivity to cardiovascular action of oxytocin but resulted in increased gene expression of PNMT in left, but not right, heart atrium in a running activity-dependent manner. | Phenylethanolamine N-methyltransferase gene expression in the heart and blood pressure response to oxytocin treatment in rats exposed to voluntary wheel running.
Bakos J, Bobryshev P, Tillinger A, Kvetnanský R, Jezova D. | 01/21/2010 |
| expression of the PNMT gene seems to be modulated through competitive binding of phosphorylated Sp1 and MAZ to their consensus elements in the promoter. | Regulation of the rat phenylethanolamine N-methyltransferase gene by transcription factors Sp1 and MAZ.
Her S, Claycomb R, Tai TC, Wong DL. | 01/21/2010 |
| PNMT gene expression and protein levels were increased after repeated stress exposure in stellate ganglia of rats and wild-type mice. The immobilization-induced increase was probably regulated by glucocorticoids. | Identification of phenylethanolamine N-methyltransferase gene expression in stellate ganglia and its modulation by stress.
Kubovcakova L, Micutkova L, Bartosova Z, Sabban EL, Krizanova O, Kvetnansky R. | 01/21/2010 |
| These results suggest that PNMT gene expression is modulated differently in cardiac atria and ventricles and might result in different physiological consequences. | Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles.
Tillinger A, Bruderova V, Kubovcakova L, Zeman M, Kopacek J, Novakova M, Kvetnansky R, Krizanova O. | 01/21/2010 |
| PNMT gene expression in the rat spleen is exaggerated by stress stimuli, suggesting its role in physiological regulations | Stress increases gene expression of phenylethanolamine N-methyltransferase in spleen of rats via pituitary-adrenocortical mechanism.
Jelokova J, Rusnak M, Kubovcakova L, Buckendahl P, Krizanova O, Sabban EL, Kvetnansky R. | 01/21/2010 |
| Glucocorticoid receptors form multimers of Pmnt independent of the DNA binding domain | Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants.
Adams M, Meijer OC, Wang J, Bhargava A, Pearce D. | 01/21/2010 |
| 15% haemorrhage significantly induced expression of PNMT in the rostral C1 region of ventrolateral medulla | Effect of haemorrhage on the expression of neurotransmitter-related genes in rat ventrolateral medulla: a quantitative real-time RT-PCR study.
Li Q, Goodchild AK, Pilowsky PM. | 01/21/2010 |
| Phenylethanolamine N-methyltransferase expression is regulated by cAMP-dependent protein kinase A and protein kinase C signaling pathways | Phenylethanolamine N-methyltransferase gene regulation by cAMP-dependent protein kinase A and protein kinase C signaling pathways.
Tai TC, Wong DL. | 01/21/2010 |
| PNMT may play a role in the regulation of fetal heart rate prior to development of the adrenal medulla [review] | Location, development, control, and function of extraadrenal phenylethanolamine N-methyltransferase.
Ziegler MG, Bao X, Kennedy BP, Joyner A, Enns R. | 01/21/2010 |
| PNMT activates both nicotinic and muscarinic receptors in vivo and in vitro | Cholinergic and peptidergic regulation of phenylethanolamine N-methyltransferase gene expression.
Wong DL, Anderson LJ, Tai TC. | 01/21/2010 |
| The results allow us to propose that in the heart, the immobilization-induced increase in PNMT gene expression is probably not in cardiomyocytes, but in neuronal cells. | Modulation by 6-hydroxydopamine of expression of the phenylethanolamine N-methyltransferase (PNMT) gene in the rat heart during immobilization stress.
Tillinger A, Novakova M, Pavlovicova M, Lacinova L, Zatovicova M, Pastorekova S, Krizanova O, Kvetnansky R. | 01/21/2010 |