| [Electroacupuncture improves limb motor function by down-regulating cytosolic phospholi-pase A2 and reducing apoptosis of nerve cells in rats with spinal cord injury]. | [Electroacupuncture improves limb motor function by down-regulating cytosolic phospholi-pase A2 and reducing apoptosis of nerve cells in rats with spinal cord injury].
Yao HH, Min YJ, Hong DY, Wang L, Lu XY, Yang YH. | 08/25/2023 |
| Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE). | Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
Bera A, Srivastava A, Dubey V, Dixit AB, Tripathi M, Sharma MC, Lalwani S, Chandra PS, Banerjee J. | 07/30/2022 |
| Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent Neuronal cPLA2 Activity in Immature Cultured Cortical Preparations. | Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent Neuronal cPLA(2) Activity in Immature Cultured Cortical Preparations.
Santerre-Anderson JL, Werner DF. | 04/3/2021 |
| These results suggest a role of cPLA2 activation in facilitating oligomeric Abeta endocytosis by microglial cells through regulation of the membrane-cytoskeleton connectivity. | Cytosolic Phospholipase A(2) Facilitates Oligomeric Amyloid-β Peptide Association with Microglia via Regulation of Membrane-Cytoskeleton Connectivity.
Teng T, Dong L, Ridgley DM, Ghura S, Tobin MK, Sun GY, LaDu MJ, Lee JC., Free PMC Article | 08/24/2019 |
| Study utilizing glutamate excitotoxicity model in rat cortical primary cell cultures suggests for the first time a more direct action of BACE1 on the hyperphosphorylation state of tau (implemented in Alzheimer's disease pathogenesis) that is mediated through cPLA2 and desaturases SCD1 and FADS6 modulation during glutamate excitotoxicity. | cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures.
Villamil-Ortiz JG, Cardona-Gómez GP. | 12/22/2018 |
| UCN counteracted TGF-beta-mediated cPLA2 expression and activation, thereby contributing to TGF-beta-mediated mitoinhibition of VSMCs | UCN enhances TGF-beta-mediated mitoinhibition of VSMCs via counteracting TGF-beta-induced cPLA2 expression and activation.
Zhu C, Cao C, Wang X, Yuan J, Jin L, Li S. | 11/11/2017 |
| These data suggest that adaptive changes induced in the myocardium by CIH may include activation of cPLA2alpha and COX-2 via beta2-AR/Gi-mediated stimulation of the ERK/p38 pathway. | Chronic intermittent hypoxia affects the cytosolic phospholipase A(2)α/cyclooxygenase 2 pathway via β(2)-adrenoceptor-mediated ERK/p38 stimulation.
Micova P, Hahnova K, Hlavackova M, Elsnicova B, Chytilova A, Holzerova K, Zurmanova J, Neckar J, Kolar F, Novakova O, Novotny J. | 02/4/2017 |
| Results showed long-term alteration in protein levels of cPLA2 and clusterin, as well as their downstream autophagy markers Beclin-1, LC3, p62 and Cathepsin-E that is in parallel with cognitive deficits and hippocampal mossy fiber sprouting following recurrent prolonged neonatal seizures, which were restored by chronic ketogenic diet treatment | Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures.
Ni H, Zhao DJ, Tian T. | 10/29/2016 |
| show that accumulation of Abeta induced elevation of APP protein expression mediated by cPLA2 alpha, PGE2 release, and CREB activation via protein kinase A pathway | The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegeneration.
Sagy-Bross C, Kasianov K, Solomonov Y, Braiman A, Friedman A, Hadad N, Levy R. | 08/13/2016 |
| IVA-PLA2 may promote CCl4-induced cell death through the suppression of constitutive autophagy in hepatocytes. | Group IVA phospholipase A(2) deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy.
Ishihara K, Kanai S, Tanaka K, Kawashita E, Akiba S. | 07/16/2016 |
| Attenuation of cPLA2 expression resulted in decreased cell migration in vascular smooth muscle cells. | Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells.
Zhu C, Cao C, Dai L, Yuan J, Li S. | 05/14/2016 |
| Data suggest glucose-induced insulin secretion is first up-regulated (acute infection), then down-regulated (chronic infection) in beta cells infected with S. aureus; Pla2g4a is up-regulated in acute infection; Pla2g6 is up-regulated in chronic infection. | Role of cytosolic and calcium independent phospholipases A(2) in insulin secretion impairment of INS-1E cells infected by S. aureus.
Caporarello N, Salmeri M, Scalia M, Motta C, Parrino C, Frittitta L, Olivieri M, Toscano MA, Anfuso CD, Lupo G. | 05/14/2016 |
| cPLA2alpha activity plays a crucial role in the signaling cascade leading to apoptotic neuronal death by aggregated Abeta1-42 | Cytosolic phospholipase A2α upregulation mediates apoptotic neuronal death induced by aggregated amyloid-β peptide1-42.
Sagy-Bross C, Hadad N, Levy R. | 06/27/2015 |
| Tregs are involved in the immunomodulatory effect mediated by cPLA2 inhibition | Protective effect of cytosolic phospholipase A2 inhibition against inflammation and degeneration by promoting regulatory T cells in rats with experimental autoimmune encephalomyelitis.
Yang D, Ji HF, Zhang XM, Yue H, Lin L, Ma YY, Huang XN, Fu J, Wang WZ., Free PMC Article | 12/20/2014 |
| Phospholipase A2 is increased in brain organ cultures following toxic levels of ethanol and increased oxidative stress. | Phospholipase A2, oxidative stress, and neurodegeneration in binge ethanol-treated organotypic slice cultures of developing rat brain.
Moon KH, Tajuddin N, Brown J 3rd, Neafsey EJ, Kim HY, Collins MA., Free PMC Article | 10/11/2014 |
| Data show that the CB1 and CB2 receptor agonists attenuate iNOS and ROS generation in microglia due to their reduction of phosphorylation of extracellular signal regulated kinase 1/2 (ERK1/2), cytosolic phospholipase A (cPLA) and activation of NF-kappaB. | Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists.
Ribeiro R, Wen J, Li S, Zhang Y. | 01/25/2014 |
| The present findings indicate that PLA2 upregulation represents an early step in glucose-induced alteration of blood-retinal barrier. | Role of phospholipases A2 in diabetic retinopathy: in vitro and in vivo studies.
Lupo G, Motta C, Giurdanella G, Anfuso CD, Alberghina M, Drago F, Salomone S, Bucolo C. | 01/11/2014 |
| H. pylori-induced ERK activation plays a critical role in up-regulation of gastric mucosal PGE2 and NO generation at the level of IKK-b and cPLA2 activation; ghrelin counters these proinflammatory events | Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK-mediated activation of IKK-β and cPLA2: modulatory effect of ghrelin.
Slomiany BL, Slomiany A. | 12/21/2013 |
| PLA2G4A plays a role in male testes physiology and development. | Group IVA phospholipase A2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation.
Kurusu S, Sapirstein A, Sawada H, Kawaminami M, Bonventre JV., Free PMC Article | 11/26/2011 |
| Data show an increase of liver group VII phospholipase A2 gene expression in the obese animals together with a strong specific inhibition of type IVA and VIA phospholipases A2. | The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
Fèvre C, Bellenger S, Pierre AS, Minville M, Bellenger J, Gresti J, Rialland M, Narce M, Tessier C. | 07/30/2011 |
| Myocardial cPLA2 level increased and is positively correlated with plasma CK-MB activity and negatively correlated with membrane phospholipid content in acute myocardial infarction rats at early stage. | Study on the relationship of cPLA2, CK-MB, and membrane phospholipid content in acute myocardial infarction.
Wei-hua L, Jun-yu H, Chang-qing S, Yong-jun G, Qiang X, Kai-min L, Rong W, Yan Z, Lin L. | 06/25/2011 |
| cPLA(2) and iPLA(2) are involved in stimulating endothelial migration and proliferation in the presence of glioma conditioned culture medium. cPLA(2) is positively regulated upstream by PI3-K, PKCalpha, and ERK1/2 signal cascades. | Cytosolic and calcium-independent phospholipase A(2) mediate glioma-enhanced proangiogenic activity of brain endothelial cells.
Giurdanella G, Motta C, Muriana S, Arena V, Anfuso CD, Lupo G, Alberghina M. | 05/28/2011 |
| Cochinchina momordica seed extract is a gastroprotective agent against acute gastric mucosal damage by suppressing proinflammatory cytokines, downregulating cPLA(2), 5-LOX, and increasing the synthesis of mucus. | Gastroprotective action of Cochinchina momordica seed extract is mediated by activation of CGRP and inhibition of cPLA(2)/5-LOX pathway.
Kang JM, Kim N, Kim B, Kim JH, Lee BY, Park JH, Lee MK, Lee HS, Jang IJ, Kim JS, Jung HC, Song IS. | 04/23/2011 |
| luteal GIVA PLA(2) plays multiple promoting roles in PGF(2alpha)-induced luteal regression at least partly by a COX-2 activity-related mechanism in pseudopregnant rats. | Evidence suggesting multiple promoting roles of luteal group IVA phospholipase A(2) in prostaglandin F(2alpha)-induced regression in pseudopregnant rats.
Kurusu S, Sonoda N, Nakahara M, Yonezawa T, Kawaminami M. | 01/22/2011 |
| cPLA(2)-dependent release of ArAc may provide a mechanism for the transactivation between the AT(1) receptor and the EGFR signaling cascade. | Angiotensin II-dependent growth of vascular smooth muscle cells requires transactivation of the epidermal growth factor receptor via a cytosolic phospholipase A(2)-mediated release of arachidonic acid.
Freeman EJ, Sheakley ML, Clements RJ. | 06/14/2010 |