| Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1alpha signaling. | Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
Pan Z, Wu X, Zhang X, Hu K. | 01/28/2023 |
| Fibroblast growth factor 23 decreases PDE4 expression in heart increasing the risk of cardiac arrhythmia; Klotho opposes these effects. | Fibroblast growth factor 23 decreases PDE4 expression in heart increasing the risk of cardiac arrhythmia; Klotho opposes these effects.
Lindner M, Mehel H, David A, Leroy C, Burtin M, Friedlander G, Terzi F, Mika D, Fischmeister R, Prié D. | 06/26/2021 |
| Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase. | Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
Xie D, Geng L, Xiong K, Zhao T, Wang S, Xue J, Wang C, Wang G, Feng Z, Zhou H, Li Y, Li L, Liu Y, Xue Z, Yang J, Ma H, Liang D, Chen YH. | 05/22/2021 |
| PDE4B is primarily responsible for muscle proteolysis in burn injury and it, thus, constitutes a unique target for selective manipulations with drugs to control muscle cachexia. | Phosphodiesterase 4B knockout prevents skeletal muscle atrophy in rats with burn injury.
Balasubramaniam A, Sheriff S, Friend LA, James JH. | 07/20/2019 |
| The mRNA expression of PDE4D was significantly increased in allergic rats, but PDE4B was not. PDE4B was mainly distributed in the cytoplasm, whereas PDE4D was mainly distributed in the cell membrane | Anti‑inflammatory effect of ciclamilast in an allergic model involving the expression of PDE4B.
Zheng XY, Chen JC, Xie QM, Chen JQ, Tang HF. | 05/25/2019 |
| PDE4B mediates a crucial PKA-dependent feedback that controls beta1 adrenergic receptor-dependent cAMP signals in a restricted subsarcolemmal domain. | PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.
Mika D, Richter W, Westenbroek RE, Catterall WA, Conti M., Free PMC Article | 11/8/2014 |
| Upregulated PDE4 expression during cholestatic liver injury plays a potential pathogenic role in the development of inflammation and fibrosis. | Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.
Gobejishvili L, Barve S, Breitkopf-Heinlein K, Li Y, Zhang J, Avila DV, Dooley S, McClain CJ., Free PMC Article | 11/30/2013 |
| Acutely after spinal cord injury, PDE4B is localized to activated microglia and is absent in uninjured spinal cord or inactive microglia. | Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury.
Ghosh M, Garcia-Castillo D, Aguirre V, Golshani R, Atkins CM, Bramlett HM, Dietrich WD, Pearse DD., Free PMC Article | 08/10/2013 |
| PDE3a, PDE4b and PDE4d isoforms mRNAs were highly expressed in the whole cervical ganglia with no modulation by hypoxia. | Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia.
Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J., Free PMC Article | 04/20/2013 |
| ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2 | ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.
Girgenti MJ, LoTurco JJ, Maher BJ., Free PMC Article | 09/1/2012 |
| Adrenergic-cyclic AMP induction of Pde4b in the pineal gland at night results in accumulation of the Pde4b2 splice variant. | Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.
Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC. | 02/26/2009 |
| Expression of Pde4b in the pineal gland is more than 6-fold higher than in other tissues, except lung. | Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.
Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC. | 02/26/2009 |
| Expression of Pde4b in the pineal gland is regulated by a neural-cyclic AMP system which produces a marked increase in transcript and protein at night. | Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.
Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC. | 02/26/2009 |
| Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation. | Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation.
Zhao H, Guan Q, Smith CJ, Quilley J. | 01/21/2010 |
| These results demonstrate for the first time that spinal cord glial cells express PDE4 subtypes and that the PDE4 inhibitor rolipram protects oligodendrocytes from secondary cell death following contusive SCI. | Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury.
Whitaker CM, Beaumont E, Wells MJ, Magnuson DS, Hetman M, Onifer SM., Free PMC Article | 01/21/2010 |
| Increased PDE4 activity, specifically phosphodiesterase 4B4 activity, reduces beta-adrenergic signaling in the kidney and contributes to salt-sensitive hypertension in the Dahl SS rat. | Renal phosphodiesterase 4B is activated in the Dahl salt-sensitive rat.
Tawar U, Kotlo K, Jain S, Shukla S, Setty S, Danziger RS. | 01/21/2010 |
| the activation of the PDE4B2 gene plays a role in the neuroinflammatory process in experimental autoimmune encephalomyelitis rats | Selective induction of cAMP phosphodiesterase PDE4B2 expression in experimental autoimmune encephalomyelitis.
Reyes-Irisarri E, Sánchez AJ, García-Merino JA, Mengod G. | 01/21/2010 |
| This study identified a specific type IV phosphodiesterase gene, PDE4B3, the first cAMP-specific phosphodiesterase to be associated with LTP. | Expression of the specific type IV phosphodiesterase gene PDE4B3 during different phases of long-term potentiation in single hippocampal slices of rats in vitro.
Ahmed T, Frey JU. | 01/21/2010 |
| Pde4B, a cAMP-specific phosphodiesterase, is upregulated by Abeta and results in an increased production of TNF-alpha | The cAMP-specific phosphodiesterase 4B mediates Abeta-induced microglial activation.
Sebastiani G, Morissette C, Lagacé C, Boulé M, Ouellette MJ, McLaughlin RW, Lacombe D, Gervais F, Tremblay P. | 01/21/2010 |
| From these results, we conclude that either the changes in PDE4B are due to modulation of pre-existing mRNA, or that the protein is specifically translocated to activated synaptic structures. | Phosphodiesterase 4B (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocampal slices during long-term potentiation in vitro.
Ahmed T, Frey JU. | 01/21/2010 |
| LTP-specific translational, but not transcriptional regulation of PDE4B3 within first 8 h after tetanization. Spatio-temporal changes of PDE4B proteins and cAMP that is LTP-specific. | Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo.
Ahmed T, Frey S, Frey JU. | 01/21/2010 |
| PDE4B2 plays a negative feedback role in adrenergic/cAMP signaling in the pineal gland. | Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.
Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC, Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC. | 01/21/2010 |