| Let-7a promotes periodontal bone regeneration of bone marrow mesenchymal stem cell aggregates via the Fas/FasL-autophagy pathway. | Let-7a promotes periodontal bone regeneration of bone marrow mesenchymal stem cell aggregates via the Fas/FasL-autophagy pathway.
Yang S, Gao J, Chen M, Sun Y, Qiao X, Mao H, Guo L, Yu Y, Yang D., Free PMC Article | 04/12/2024 |
| Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models. | Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models.
Song Z, Tian X, Shi Q. | 08/21/2021 |
| MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia Through Regulating the FAS/FAS-L Signaling Pathway. | MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia Through Regulating the FAS/FAS-L Signaling Pathway.
Tang H, Zhang S, Huang C, Li K, Zhao Q, Li X. | 06/12/2021 |
| The physiological release and pharmacological concentration of melatonin may improve protective effect of RIPerC against I/R-induced infarct size by modulating Cybb, Fas, NfkappaB, Irisin signaling pathways. | Physiological and pharmacological effects of melatonin on remote ischemic perconditioning after myocardial ischemia-reperfusion injury in rats: Role of Cybb, Fas, NfκB, Irisin signaling pathway.
Gul-Kahraman K, Yilmaz-Bozoglan M, Sahna E. | 01/11/2020 |
| Taken together, these results demonstrate that the Fas/FasL-mediated mitochondrial apoptotic pathway plays an important role in cadmium-induced neuronal apoptosis. | Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway.
Yuan Y, Zhang Y, Zhao S, Chen J, Yang J, Wang T, Zou H, Wang Y, Gu J, Liu X, Bian J, Liu Z., Free PMC Article | 10/19/2019 |
| The expression of apoptosis-related genes Fas and FasL in rats with an experimentally induced left-side varicocele was significantly increased compared to that in the control group. | Roles of Fas/FasL-mediated apoptosis and inhibin B in the testicular dysfunction of rats with left-side varicocele.
Zhang J, Jin PP, Gong M, Guo JH, Fang K, Yi QT, Zhu RJ. | 09/22/2018 |
| Report dysregulation of the Fas/FasL system occurs in an experimental animal model of HELLP syndrome. | Dysregulation of the Fas/FasL system in an experimental animal model of HELLP syndrome.
Gibbens J, Morris R, Bowles T, Spencer SK, Wallace K., Free PMC Article | 03/24/2018 |
| Vitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in diabetic cardiomyopathy rats, which might be used as a potential effective therapy for the disease. | Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy.
Zeng X, Yu X, Xiao S, Yao H, Zhu J., Free PMC Article | 03/17/2018 |
| Study found that propofol anesthesia activates Fas/FasL-mediated extrinsic and Bcl-2-dependent intrinsic apoptotic pathways, resulting in caspase-8 and caspase-9 activations, respectively, and established upregulation of caspase-1 and IL-1beta cytokine transcriptions as well as subsequent activation of microglia. Behavioral data revealed that hyperactivity persists through adolescence and young adulthood. | The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats.
Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Pavkovic Z, Popic J, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. | 07/29/2017 |
| NaIO3 activates Fas-mediated cell death, both in the RPE and photoreceptor, and that a small peptide antagonist of the Fas receptor, Met12, significantly reduces the extent of this cell death. | Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Xiao J, Yao J, Jia L, Lin C, Zacks DN., Free PMC Article | 07/1/2017 |
| Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14. | Differential activation of CD95-mediated apoptosis related proteins in proximal and distal tubules during rat renal development.
Song XF, Tian H, Zhang ZX. | 03/25/2017 |
| miR-133b-5p might play a particularly important role in the cardioprotective effect of morphine preconditioning by regulating the target gene Fas | Specific MicroRNAs comparisons in hypoxia and morphine preconditioning against hypoxia-reoxgenation injury with and without heart failure.
Zhu HJ, Han ZY, He SF, Jin SY, Xu SJ, Fang XD, Zhang Y. | 03/4/2017 |
| Hepatitis B virus X protein modulates apoptosis in tubule renal cells and activates Fas/FasL through the MLK3-MKK7-JNK3 signaling pathway. | Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway.
He P, Zhang B, Liu D, Bian X, Li D, Wang Y, Sun G, Zhou G. | 02/4/2017 |
| Organic pollutants in drinking water impair liver function, with the involvement of Fas and mitochondria-mediated apoptosis in rats. | Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water.
Yang G, Zhou Z, Cen Y, Gui X, Zeng Q, Ao Y, Li Q, Wang S, Li J, Zhang A., Free PMC Article | 06/4/2016 |
| These results indicate that chorionic gonadotropin promotes follicular development via downregulation of death-inducer Fas/FasL expression and promotion of ovarian cell proliferation. | Effects of gonadotropin on Fas and/or FasL expression and proliferation in rat ovary.
Guan S, Guo L, Zhang T, Zhu B, Wang X, Zhang C. | 08/15/2015 |
| Sulforafan inhibited galactosamine/lipopolysaccharide induced caspase-3 activation and suppressed FAS and FASL expression. | Sulforaphane increases the survival rate in rats with fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide.
Sayed RH, Khalil WK, Salem HA, Kenawy SA, El-Sayeh BM. | 08/8/2015 |
| Mip1 over-expression inhibited H2O2-induced apoptosis and upregulation of Fas induced by H2O2 in H9c2 myogenic cells. | Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas.
Wang G, Jiang L, Song J, Zhou SF, Zhang H, Wang K, Xiao X., Free PMC Article | 06/27/2015 |
| Hepatocyte apoptosis could promote NAFLD progression; Fas, FasL, and Caspase-8 mRNA activation were important contributing factors to NAFLD. The upregulation of Bax and Bcl-2 expression might be one important mechanism of the apoptosis in NAFLD. | Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis.
Li CP, Li JH, He SY, Li P, Zhong XL. | 02/14/2015 |
| Chronic methamphetamine exposure will activate cardiac Fas-dependent and mitochondria-dependent apoptotic pathways. | Chronic methamphetamine exposure induces cardiac fas-dependent and mitochondria-dependent apoptosis.
Liou CM, Tsai SC, Kuo CH, Williams T, Ting H, Lee SD. | 01/17/2015 |
| Kruppel-like factor 6 rendered rat Schwann cell more sensitive to apoptosis via upregulating FAS expression. | Krüppel-like factor 6 rendered rat Schwann cell more sensitive to apoptosis via upregulating FAS expression.
Gui T, Wang Y, Zhang L, Wang W, Zhu H, Ding W., Free PMC Article | 08/9/2014 |
| The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis. | The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons.
Huang X, Lu Z, Lv Z, Yu T, Yang P, Shen Y, Ding Y, Fu D, Zhang X, Fu Q, Yu Y., Free PMC Article | 03/8/2014 |
| Fas protein was up-regulated in rat mesangial cells, and its neutralizing antibody ZB4 partly inhibited M2 macrophage-induced apoptosis | Conditioned medium from alternatively activated macrophages induce mesangial cell apoptosis via the effect of Fas.
Huang Y, Luo F, Li H, Jiang T, Zhang N. | 02/15/2014 |
| Prolonged mechanical ventilation induces apoptosis of alveolar type II cells in newborn rats via the extrinsic death pathway and the FasL/Fas system. | Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway.
Kroon AA, Delriccio V, Tseu I, Kavanagh BP, Post M. | 02/1/2014 |
| Fas and TNFR1 are expressed in the CA1 and CA3 regions after global ischemia/reperfusion in rats. Bcl-2 overexpression decreases the expression of Fas and TNFR1 and cell apoptosis after global IR. | [Fas and TNFR1 expressions after cerebral ischemia and reperfusion in rats: association with cell apoptosis and the effects of Bcl-2 overexpression].
Wu G, Xue RL, Lv JR, Li W, Lei XM. | 05/4/2013 |
| In summary, the Fas/FasL pathway involved in alveolar epithelial cell apoptosis could be important in the pathogenesis of seawater-induced acute lung injury | Seawater induces apoptosis in alveolar epithelial cells via the Fas/FasL-mediated pathway.
Han F, Luo Y, Li Y, Liu Z, Xu D, Jin F, Li Z. | 11/3/2012 |