| HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects. | HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects.
He X, Guo X, Deng B, Kang J, Liu W, Zhang G, Wang Y, Yang Y, Kang X. | 02/4/2023 |
| Chaperone Hsp70 (HSPA1) Is Involved in the Molecular Mechanisms of Sleep Cycle Integration. | Chaperone Hsp70 (HSPA1) Is Involved in the Molecular Mechanisms of Sleep Cycle Integration.
Simonova VV, Guzeev MA, Ekimova IV, Pastukhov YF., Free PMC Article | 04/30/2022 |
| Inducible heat shock protein A1A (HSPA1A) is markedly expressed in rat myometrium by labour and secreted via myometrial cell-derived extracellular vesicles. | Inducible heat shock protein A1A (HSPA1A) is markedly expressed in rat myometrium by labour and secreted via myometrial cell-derived extracellular vesicles.
Russell MF, Bailey GC, Miskiewicz EI, MacPhee DJ. | 11/6/2021 |
| Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway. | Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway.
Pan Z, Wu Q, Xie Z, Wu Q, Tan X, Wang X. | 08/7/2021 |
| Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress. | Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress.
Mikeladze MA, Dutysheva EA, Kartsev VG, Margulis BA, Guzhova IV, Lazarev VF., Free PMC Article | 04/24/2021 |
| HSP70 specifically binds to S394-phosphorylated HDAC2 and maintains its phosphorylation status, which results in HDAC2 activation and the development of cardiac hypertrophy. | Inhibition of heat shock protein 70 blocks the development of cardiac hypertrophy by modulating the phosphorylation of histone deacetylase 2.
Yoon S, Kim M, Min HK, Lee YU, Kwon DH, Lee M, Lee S, Kook T, Joung H, Nam KI, Ahn Y, Kim YK, Kim J, Park WJ, McMullen JR, Eom GH, Kook H. | 08/1/2020 |
| These results suggest that heat-stress-induced HSP72 within the myofibers, blood vessels, and circulating leukocytes may play important roles in enhancing regeneration of injured muscles by heat stress. | Role of 72-kDa Heat Shock Protein in Heat-stimulated Regeneration of Injured Muscle in Rat.
Kami K, Ohira T, Oishi Y, Nakajima T, Goto K, Ohira Y., Free PMC Article | 06/20/2020 |
| Thermal stress could increase pancreatic HSP70 expression, and induced HSP70 expression showed a protective effect against pancreatic fibrosis. | Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride.
Lee JM, Lee KG, Choi HS, Kim ES, Keum B, Seo YS, Jeen YT, Chun HJ, Lee HS, Um SH, Kim CD. | 04/20/2019 |
| HSPA1A overexpression promotes osteogenic differentiation of bone marrow mesenchymal cells, partly through Wnt/beta-catenin. | Overexpression of HSPA1A enhances the osteogenic differentiation of bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signaling pathway.
Zhang W, Xue D, Yin H, Wang S, Li C, Chen E, Hu D, Tao Y, Yu J, Zheng Q, Gao X, Pan Z., Free PMC Article | 04/28/2018 |
| uHSP72 could be used as an early biomarker to detect subtle to severe tubular injury. | HSP72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity.
Pérez-Villalva R, Barrera-Chimal J, Aguilar-Carrasco JC, Lima-Posada I, Cruz C, Ramírez V, González-Bobadilla Y, Uribe N, Trumper L, Bobadilla NA. | 04/21/2018 |
| HSP72 is released extracellularly in response to stress, promoting thrombus formation and acute myocardial infarction . | Heat-shock protein 72 promotes platelet aggregation induced by various platelet activators in rats.
Suzuki H, Kosuge Y, Kobayashi K, Kurosaki Y, Ishii N, Aoyama N, Ishihara K, Ichikawa T. | 03/31/2018 |
| HSP70 also interacted with C-terminal fragment of eEF2, which could reverse the nucleus translocation and cardiomyocyte apoptosis caused by N-terminal fragment of eEF2. HSP70 draw on advantage and avoid defect of MIR through regulating phosphorylation and nucleus translocation of eEF2 | Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.
Zhang C, Liu X, Miao J, Wang S, Wu L, Yan D, Li J, Guo W, Wu X, Shen A. | 02/24/2018 |
| Twelve hours following heatstroke induction, cardiac HSP72 expression is increased, compared with normothermic controls. | Heat shock protein 72 may improve hypotension by increasing cardiac mechanical efficiency and arterial elastance in heatstroke rats.
Hsu SF, Chao CM, Chang CP, Lin MT, Cheng BC. | 08/5/2017 |
| Diet-induced elevation of circulating HSP70 could trigger cell adhesion with the help of IL-6 as a mediator. | Diet-induced elevation of circulating HSP70 may trigger cell adhesion and promote the development of atherosclerosis in rats.
Xie F, Zhan R, Yan LC, Gong JB, Zhao Y, Ma J, Qian LJ., Free PMC Article | 03/11/2017 |
| Data show that heat shock 70 kDa protein (Hsp72) increased exclusively in the renal cortex of ischemia and reperfusion (I/R) group, indicating its performance as an acute kidney injury (AKI) biomarker. | Heat shock protein 72 (Hsp72) specific induction and temporal stability in urine samples as a reliable biomarker of acute kidney injury (AKI).
Ortega-Trejo JA, Pérez-Villalva R, Barrera-Chimal J, Carrillo-Pérez DL, Morales-Buenrostro LE, Gamba G, Flores ME, Bobadilla NA. | 09/17/2016 |
| HSP72 blocks fibroblast activation and proliferation in renal fibrosis via targeting the STAT3 pathway and may serve as a novel therapeutic agent for chronic kidney disease regardless of the etiology | Heat Shock Protein 72 Antagonizes STAT3 Signaling to Inhibit Fibroblast Accumulation in Renal Fibrogenesis.
Zhou Y, Cao S, Li H, Peng X, Wang Y, Fan J, Wang Y, Zhuang S, Yu X, Mao H. | 09/10/2016 |
| This study investigated changes in the myokines IL-1beta, IL-6, and TNF-alpha, as well as HSP72, after endurance training and after a session of downhill running. | The effect of endurance training and downhill running on the expression of IL-1β, IL-6, and TNF-α and HSP72 in rat skeletal muscle.
Isanejad A, Saraf ZH, Mahdavi M, Gharakhanlou R, Shamsi MM, Paulsen G. | 02/13/2016 |
| exposing male Fisher 344 rats to an acute stressor modulates the protein and miRNA profile of circulating plasma exosomes, specifically increasing surface heat shock protein 72 (Hsp72) and decreasing miR-142-5p and -203. | Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72) and microRNA (miR-142-5p and miR-203).
Beninson LA, Brown PN, Loughridge AB, Saludes JP, Maslanik T, Hills AK, Woodworth T, Craig W, Yin H, Fleshner M., Free PMC Article | 01/16/2016 |
| increases in the levels of circulating Hsp72 had a beneficial effect in improving animal survival during the progress of sepsis. | Release of endogenous heat shock protein 72 on the survival of sepsis in rats.
Tsai TN, Lee TY, Liu MS, Chuang IC, Lu MC, Dong HP, Lue SI, Yang RC. | 11/14/2015 |
| HSP72 preserves renal function in I/R injury through its antiapoptotic effects, which act by suppressing mitochondrial Smac/Diablo release and preserving XIAP protein content. | Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury.
Zhang B, Rong R, Li H, Peng X, Xiong L, Wang Y, Yu X, Mao H., Free PMC Article | 10/17/2015 |
| Short-term but not long-term hypoglycaemia enhances plasma levels and hepatic expression of HSP72 in insulin-treated rats: an effect associated with increased IL-6 levels but not with IL-10 or TNF-alpha. | Short-term but not long-term hypoglycaemia enhances plasma levels and hepatic expression of HSP72 in insulin-treated rats: an effect associated with increased IL-6 levels but not with IL-10 or TNF-α.
Ludwig MS, Minguetti-Câmara VC, Heck TG, Scomazzon SP, Nunes PR, Bazotte RB, Homem de Bittencourt PI Jr. | 07/4/2015 |
| Exercise preconditioning increased the neuronal and astroglial levels of HSP72 in the gray matter of normal spinal cord tissue and promoted functional recovery after spinal cord injury. | Exercise preconditioning protects against spinal cord injury in rats by upregulating neuronal and astroglial heat shock protein 72.
Chang CK, Chou W, Lin HJ, Huang YC, Tang LY, Lin MT, Chang CP., Free PMC Article | 06/27/2015 |
| nucleolin is up-regulated and involved in myocardial protection of ischaemic preconditioning via a post-transcriptional control of HSPA1A expression | Nucleolin involved in myocardial ischaemic preconditioning via post-transcriptional control of HSPA1A expression.
Jiang B, Liang P, Wang K, Lv C, Sun L, Tong Z, Liu Y, Xiao X. | 11/29/2014 |
| These data indicate that Hsp70i upregulation may provide hippocampal cellular protection against chronic social isolation stress mediated by downregulation of iNOS protein expression through suppression of NF-kappaB activation. | Protective effect of Hsp70i against chronic social isolation stress in the rat hippocampus.
Zlatković J, Bernardi RE, Filipović D. | 08/23/2014 |
| The data of this study demonstrated a new mechanism linking TBI-induced hemorrhage and neuronal injury to the suppression of MMPs by Hsp70, and support the development of Hsp70 enhancing strategies for the treatment of TBI. | The 70 kDa heat shock protein protects against experimental traumatic brain injury.
Kim JY, Kim N, Zheng Z, Lee JE, Yenari MA., Free PMC Article | 04/26/2014 |