| miR-3120/Hsc70 participates in forced swim stress-induced mechanical hyperalgesia in rats in an inflammatory state. | miR‑3120/Hsc70 participates in forced swim stress‑induced mechanical hyperalgesia in rats in an inflammatory state.
Xu S, Liu S, Yang J, Li R, Mao M, Feng S, Wang X., Free PMC Article | 11/15/2023 |
| Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-kappaB/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury. | Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-κB/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury.
Mi J, Yang Y, Yao H, Huan Z, Xu C, Ren Z, Li W, Tang Y, Fu R, Ge X., Free PMC Article | 01/15/2022 |
| Carboxyl terminus of Hsc70-interacting protein (CHIP) promotes pulmonary artery smooth muscle cell (PASMC) proliferation via enhancement of intracellular Ca(2+) concentration ([Ca(2+)]i). | Carboxyl terminus of Hsc70-interacting protein (CHIP) promotes pulmonary artery smooth muscle cell (PASMC) proliferation via enhancement of intracellular Ca(2+) concentration ([Ca(2+)](i)).
Dong F, Zhang J. | 08/21/2021 |
| Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells. | Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells.
Ikezaki M, Nishioka N, Nishikawa T, Higashimoto N, Ihara Y. | 01/9/2021 |
| HSPA8 is a Clcn2 accessory protein. | Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.
Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K., Free PMC Article | 06/13/2020 |
| Study of intraventricular septum samples from hypertrophic cardiomyopathy patients and a panel of human MYBPC3 mutations expressed in neonatal rat ventricular cardiomyocytes revealed suggest that wild type and mutant MYBPC3 proteins are clients for HSC70, and that the HSC70 chaperone system plays a major role in regulating MYBPC3 protein turnover. | HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.
Glazier AA, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii AI, Lee LM, Shao H, Tang V, Yob JM, Gestwicki JE, Helms AS, Day SM., Free PMC Article | 11/2/2019 |
| Synapsin is part of a multiprotein complex enriched in chaperones/cochaperones including Hsc70. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. | Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S., Free PMC Article | 09/16/2017 |
| these data demonstrate a novel interaction between Hsc70 and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 in dopamine homeostasis. | The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization.
Parra LA, Baust TB, Smith AD, Jaumotte JD, Zigmond MJ, Torres S, Leak RK, Pino JA, Torres GE., Free PMC Article | 05/13/2017 |
| Pulsed electromagnetic wave exposure induced ultrastructural damage and the overexpression of HSP70 in the nuclei in the adenohypophysis. | Pulsed electromagnetic wave exposure induces ultrastructural damage and upregulated expression of heat shock protein 70 in the rat adenohypophysis.
Cheng K, Ren DQ, Yi J, Zhou XG, Yang WQ, Chen YB, Li YQ, Huang XF, Zeng GY. | 03/19/2016 |
| These findings demonstrate that Hsc70 chaperone activity is required for Rac1 activation by Trio and this function underlies netrin-1/DCC-dependent axon outgrowth and guidance. | Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.
DeGeer J, Kaplan A, Mattar P, Morabito M, Stochaj U, Kennedy TE, Debant A, Cayouette M, Fournier AE, Lamarche-Vane N., Free PMC Article | 12/19/2015 |
| these data provide evidence for Hsc70 as a novel neuronal interactor of NF-kappaB p65. | Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.
Klenke C, Widera D, Engelen T, Müller J, Noll T, Niehaus K, Schmitz ML, Kaltschmidt B, Kaltschmidt C., Free PMC Article | 01/25/2014 |
| The level of 70 kDa heat shock cognate (HSC70) expression was greater in the diencephalon of the 3 ppm Fe group. | Responses of HSC70 expression in diencephalon to iron deficiency anemia in rats.
Kawano F, Oke Y, Nomura S, Fujita R, Ohira T, Nakai N, Ohira Y., Free PMC Article | 05/19/2012 |
| this rearch suggests that the protective effect of Hsc70 on the cardiomyocytes against oxidative stress is partly associated with its interaction with alpha-enolase. | Constitutive heat shock protein 70 interacts with α-enolase and protects cardiomyocytes against oxidative stress.
Luo Q, Jiang L, Chen G, Feng Y, Lv Q, Zhang C, Qu S, Zhu H, Zhou B, Xiao X. | 03/10/2012 |
| Hsc70 binding appears highly sensitive to the duration of its binding cycle, which is in turn governed by the integrated expression of regulatory cochaperones | Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.
Matsumura Y, David LL, Skach WR., Free PMC Article | 12/10/2011 |
| A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin. | A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin.
Rothnie A, Clarke AR, Kuzmic P, Cameron A, Smith CJ., Free PMC Article | 06/25/2011 |
| BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. | BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress.
Hishiya A, Kitazawa T, Takayama S., Free PMC Article | 01/1/2011 |
| data demonstrate for the first time that HSP70 overexpression with adenovirus injection prevented the lipopolysaccharide-induced increase in tumor necrosis factor-alpha and IL-6 levels in rats. | LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB.
Dokladny K, Lobb R, Wharton W, Ma TY, Moseley PL., Free PMC Article | 04/12/2010 |
| A purified Hsc70 fragment that binds vesicular monoamine transporter-2 (VMAT2) inhibits VMAT2 activity in synaptic vesicles. | The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2.
Requena DF, Parra LA, Baust TB, Quiroz M, Leak RK, Garcia-Olivares J, Torres GE. | 01/21/2010 |
| structural basis of HSC70 oligomerization; 2 non-contiguous regions, located at both ends of the C-terminal domain, appear to form the contact interface in the oligomers & may interact in dynamic fashion leading to formation of several coexisting species | Involvement of the interdomain hydrophobic linker and the C-terminal helices in self-association of the molecular chaperone HSC70.
Amor-Mahjoub M, Gomez-Vrielyunck N, Suppini JP, Fouchaq B, Benarouj N, Ladjimi M. | 01/21/2010 |
| The results suggest that the involvement of NF-kappaB p65 in nuclear translocation of Ku70 may be mediated by Hsc70 degradation, which may play a key role in cell proliferation of pancreatic acinar AR42J cells. | NF-kappaB p65 regulates nuclear translocation of Ku70 via degradation of heat shock cognate protein 70 in pancreatic acinar AR42J cells.
Lim JW, Kim KH, Kim H. | 01/21/2010 |
| Extracellular HSC70 plays a critical role in regulating the myocardial innate immune response and cardiac function after ischemia-reperfusion. | Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion.
Zou N, Ao L, Cleveland JC Jr, Yang X, Su X, Cai GY, Banerjee A, Fullerton DA, Meng X., Free PMC Article | 01/21/2010 |
| ASIC2-Hsc70 interactions may play a role in vascular smooth muscle cell migration and contribute to vasculogenesis and remodeling. | Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration.
Grifoni SC, McKey SE, Drummond HA. | 01/21/2010 |
| alphaD-alphaE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. | Analysis of monomeric mutants of HSC70: a possible relationship between oligomerization and functional properties.
Amor-Mahjoub M, Gomez-Vrielyunck N, Suppini JP, Fouchaq B, Benaroudj N, Ladjimi M. | 01/21/2010 |
| 70-kDa heat shock proteins as a AQP2 interactors and have shown for hsc70 that this interaction is involved in AQP2 trafficking. | Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking.
Lu HAJ, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D. | 01/21/2010 |
| Analysis of constitutively expressed heat shock proteins revealed variable levels of Hsc70 and Hsp27 in different classes of neurons in the adult rat brain. | Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases.
Chen S, Brown IR., Free PMC Article | 01/21/2010 |