| This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction. | Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver.
Yang S, Ma Y, Liu Y, Que H, Zhu C, Liu S. | 06/1/2013 |
| Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats | Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats.
Ruth MR, Wang Y, Yu HM, Goruk S, Reaney MJ, Proctor SD, Vine DF, Field CJ., Free PMC Article | 06/9/2012 |
| activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator. | Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response.
Arambasić J, Poznanović G, Ivanović-Matić S, Bogojević D, Mihailović M, Uskoković A, Grigorov I. | 06/28/2010 |
| Pulmonary embolism that causes pulmonary hypertension is associated with haptoglobin depletion and up-regulation of HMOX1 enzyme. | Rapid clearance of circulating haptoglobin from plasma during acute pulmonary embolism in rats results in HMOX1 up-regulation in peripheral blood leukocytes.
Zagorski J, Marchick MR, Kline JA. | 05/31/2010 |
| Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury. | Neuroprotective role of haptoglobin after intracerebral hemorrhage.
Zhao X, Song S, Sun G, Strong R, Zhang J, Grotta JC, Aronowski J., Free PMC Article | 02/1/2010 |
| lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription. | Regulation of rat haptoglobin gene expression is coordinated by the nuclear matrix.
Vidaković M, Dinić S, Grdović N, Mihailović M, Uskoković A, Quesada P, Poznanović G. | 01/21/2010 |
| Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response. | Differences between molecular mechanisms involved in the regulation of haptoglobin gene expression during the acute phase response and dietary restriction.
Uskoković A, Arambasić J, Bogojević D, Ivanović-Matić S, Mihailović M, Dinić S, Grigorov I. | 01/21/2010 |
| Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals. | Markedly increased urinary preprohaptoglobin and haptoglobin in passive Heymann nephritis: a differential proteomics approach.
Ngai HH, Sit WH, Jiang PP, Thongboonkerd V, Wan JM. | 01/21/2010 |
| that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. | Regulation of C/EBPdelta-dependent transactivation by histone deacetylases in intestinal epithelial cells.
Turgeon N, Valiquette C, Blais M, Routhier S, Seidman EG, Asselin C. | 01/21/2010 |
| upregulated in reactive astrocytes after transient forebrain ischemia in rats | Upregulation of haptoglobin in reactive astrocytes after transient forebrain ischemia in rats.
Lee MY, Kim SY, Choi JS, Lee IH, Choi YS, Jin JY, Park SJ, Sung KW, Chun MH, Kim IS. | 01/21/2010 |
| Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the acute-phase response regulation during the later phase of differentiation and in the adult. | C/EBP alpha and C/EBP beta regulate haptoglobin gene expression during rat liver development and the acute-phase response.
Dinić S, Bogojević D, Petrović M, Poznanović G, Ivanovic-Matić S, Mihailović M. | 01/21/2010 |
| Haptoglobin gene expression regulation | Haptoglobin, an inflammation-inducible plasma protein.
Wang Y, Kinzie E, Berger FG, Lim SK, Baumann H. | 01/21/2010 |
| Hp-mediated haemoglobin catabolism in lung cells may be an efficient mechanism to reduce oxidative damage associated with haemolysis | Haptoglobin in lung defence.
Yang F, Haile DJ, Coalson JJ, Ghio AJ. | 01/21/2010 |
| Hp is transcriptionally modulated throughout prenatal hepatic development by fetal p53 protein. | p53-like protein binding affinity to the hormone responsive element of the haptoglobin gene in fetal rat livers.
Bogojević D, Petrović M, Mihailović M. | 01/21/2010 |