| UBP791 ((2S*,3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity over GluN2A-containing receptors, and that a methionine and a lysine residue in the ligand binding pocket are the critical molecular elements for the subtype-specific binding. | Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors.
Wang JX, Irvine MW, Burnell ES, Sapkota K, Thatcher RJ, Li M, Simorowski N, Volianskis A, Collingridge GL, Monaghan DT, Jane DE, Furukawa H., Free PMC Article | 04/18/2020 |
| a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia. | Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia.
Chung C, Marson JD, Zhang QG, Kim J, Wu WH, Brann DW, Chen BS., Free PMC Article | 05/19/2018 |
| these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface | Identification of Novel 14-3-3 Residues That Are Critical for Isoform-specific Interaction with GluN2C to Regulate N-Methyl-D-aspartate (NMDA) Receptor Trafficking.
Chung C, Wu WH, Chen BS., Free PMC Article | 12/19/2015 |
| These results support a critical role for GluN2C receptors in the amygdala in the consolidation of learned fear responses. | Potentiation of GluN2C/D NMDA receptor subtypes in the amygdala facilitates the retention of fear and extinction learning in mice.
Ogden KK, Khatri A, Traynelis SF, Heldt SA., Free PMC Article | 09/13/2014 |
| Data indicate that tetrahydroisoquinolines showed subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. | Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.
Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC., Free PMC Article | 03/15/2014 |
| NR2C expression has an initial rise from postnatal day P2 to P3, but remains relatively constant thereafter until P21, except for a significant fall at P12 in the pre-Botzinger complex. | Postnatal development of N-methyl-D-aspartate receptor subunits 2A, 2B, 2C, 2D, and 3B immunoreactivity in brain stem respiratory nuclei of the rat.
Liu Q, Wong-Riley MT., Free PMC Article | 11/5/2011 |
| PKB/Akt directly phosphorylates NR2C on serine 1096 | Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C.
Chen BS, Roche KW., Free PMC Article | 01/21/2010 |
| Hindbrain injection of competitive NMDA antagonists with selectivity or preference for the NMDA receptor NR2B or NR2C subunits increases food intake. | Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intake.
Guard DB, Swartz TD, Ritter RC, Burns GA, Covasa M., Free PMC Article | 01/21/2010 |
| NMDA2C and NMDA2D subunits are in the rat striatum | Cholinergic neurons of the adult rat striatum are immunoreactive for glutamatergic N-methyl-d-aspartate 2D but not N-methyl-d-aspartate 2C receptor subunits.
Bloomfield C, O'Donnell P, French SJ, Totterdell S., Free PMC Article | 01/21/2010 |
| the basal levels of activated NF-kappaB in cortical neurons are maintained partially by synaptic activity involving N-methyl- D-aspartate (NMDA) and AMPA/kainate glutamate receptors | Involvement of NMDA receptors and a p21Ras-like guanosine triphosphatase in the constitutive activation of nuclear factor-kappa-B in cortical neurons.
Burr PB, Morris BJ. | 01/21/2010 |
| A novel form of NMDAR-dependent long-term depression (iLTD) is associated with CI-mossy fiber synapses. | Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
Lei S, McBain CJ. | 01/21/2010 |
| The natural exchange of the NR2B receptor subunit by the NR2C subunit in wild-type cerebellar granule cells is an important prerequisite of accurate cerebellar development and function, as shown in experiments with NR2C-deficient mice. | Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits.
Schlett K, Pieri I, Metzger F, Marchetti L, Steigerwald F, Dere E, Kirilly D, Tárnok K, Barabás B, Varga AK, Gerspach J, Huston J, Pfizenmaier K, Köhr G, Eisel UL. | 01/21/2010 |
| activation of adenylate cyclase by PACAP(1-38) results in the release of RACK1 from the NMDA receptor and Fyn | Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1.
Yaka R, He DY, Phamluong K, Ron D. | 01/21/2010 |
| SCI-induced NMDA receptor activation leads to changes in mRNA levels of many genes relevant to the recovery processes. | DNA microarray analysis of the contused spinal cord: effect of NMDA receptor inhibition.
Nesic O, Svrakic NM, Xu GY, McAdoo D, Westlund KN, Hulsebosch CE, Ye Z, Galante A, Soteropoulos P, Tolias P, Young W, Hart RP, Perez-Polo JR. | 01/21/2010 |
| NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1 | NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1.
Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D., Free PMC Article | 01/21/2010 |
| extensive colocalization of estrogen receptor alpha and the N-methyl-D-aspartate receptor provides an anatomical level at which estrogen and glutamate can act at target cells | Colocalization and hormone regulation of estrogen receptor alpha and N-methyl-D-aspartate receptor in the hypothalamus of female rats.
Chakraborty TR, Ng L, Gore AC. | 01/21/2010 |
| NMDA receptor activation results in increased NOS activity and attenuated development of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung. | Nmda alters the development of hypoxic pulmonary vasoconstriction and nitric oxide synthetase activity in the isolated perfused rat lung.
Polak MJ, Xiao S, Ashton CA, Baylis C. | 01/21/2010 |
| Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. | Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation.
Holmin S, Mathiesen T, Langmoen IA, Sandberg Nordqvist AC. | 01/21/2010 |
| upregulation of NMDAR activity by dopamine D1 receptors. | Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex.
Chen G, Greengard P, Yan Z., Free PMC Article | 01/21/2010 |
| The present results indicate that striatal and nigral neurons are programmed to express distinct NMDA receptor subunits during their endogenous development in cell cultures. | Striatal neurons but not nigral dopaminergic neurons in neonatal primary cell culture express endogenous functional N-methyl-D-aspartate receptors.
Lui PW, Suen KC, Chan YS, Yung WH, Yung KK. | 01/21/2010 |
| Early postnatal blockade of NMDA using the non-competitive antagonist dizocilpine maleate arrested developmental decrease in electrotonic and dye coupling during first postnatal week. | Increased incidence of gap junctional coupling between spinal motoneurones following transient blockade of NMDA receptors in neonatal rats.
Mentis GZ, Díaz E, Moran LB, Navarrete R., Free PMC Article | 01/21/2010 |
| we report that dopamine D1 receptors modulate NMDA glutamate receptor-mediated functions through direct protein-protein interactions | Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor.
Lee FJ, Xue S, Pei L, Vukusic B, Chéry N, Wang Y, Wang YT, Niznik HB, Yu XM, Liu F. | 01/21/2010 |
| EphrinB2 stimulation of EphB modulates the functional consequences of NMDA receptor activation; suggest a mechanism whereby activity-independent and dependent signals converge to regulate the development and remodeling of synaptic connections. | Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.
Takasu MA, Dalva MB, Zigmond RE, Greenberg ME. | 01/21/2010 |
| Costimulation of N-methyl-D-aspartate and muscarinic neuronal receptors modulates gap junctional communication in striatal astrocytes. | Costimulation of N-methyl-D-aspartate and muscarinic neuronal receptors modulates gap junctional communication in striatal astrocytes.
Rouach N, Tencé M, Glowinski J, Giaume C., Free PMC Article | 01/21/2010 |
| Early maternal deprivation reduces the expression of subunits in rat hippocampus. | Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus.
Roceri M, Hendriks W, Racagni G, Ellenbroek BA, Riva MA. | 01/21/2010 |