| The inhibition of CFTR in the descended testis of SD rats with unilateral cryptorchidism induced by di-(2-ethylhexyl) phthalate (DEHP). | The inhibition of CFTR in the descended testis of SD rats with unilateral cryptorchidism induced by di-(2-ethylhexyl) phthalate (DEHP).
Tang X, Li D, Zhao T, Zhu S, Gao X, Zhou R, Deng F, Fu W, Jia W, Liu G. | 10/29/2022 |
| CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells. | CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells.
Lu LY, Pan N, Huang ZH, Wang JS, Tang YB, Sun HS, Han H, Yang HY, Zhu JZ, Guan YY, Zhang B, Li DZ, Wang GL., Free PMC Article | 06/25/2022 |
| Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension. | Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension.
Le Ribeuz H, To L, Ghigna MR, Martin C, Nagaraj C, Dreano E, Rucker-Martin C, Girerd B, Bouligand J, Pechoux C, Lambert M, Boet A, Issard J, Mercier O, Hoetzenecker K, Manoury B, Becq F, Burgel PR, Cottart CH, Olschewski A, Sermet-Gaudelus I, Perros F, Humbert M, Montani D, Antigny F. | 01/1/2022 |
| Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model. | Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model.
Wang Y, Gu L, Yang HM, Zhang H. | 12/11/2021 |
| Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation. | Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation.
Wang Y, Zhao J, Cai Y, Ballard HJ. | 07/31/2021 |
| Heterogeneous expression of CFTR in insulin-secreting beta-cells of the normal human islet. | Heterogeneous expression of CFTR in insulin-secreting β-cells of the normal human islet.
Di Fulvio M, Bogdani M, Velasco M, McMillen TS, Ridaura C, Kelly L, Almutairi MM, Kursan S, Sajib AA, Hiriart M, Aguilar-Bryan L., Free PMC Article | 01/16/2021 |
| Cellular mechanism underlying oxytocin-stimulated Cl(-) secretion in rat cauda epididymal epithelium. | Cellular mechanism underlying oxytocin-stimulated Cl(-) secretion in rat cauda epididymal epithelium.
Gao DD, Wang LL, Xu JW, Qiu ZE, Zhu YX, Zhang YL, Zhou WL. | 12/19/2020 |
| TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels. | TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels.
Genovese M, Borrelli A, Venturini A, Guidone D, Caci E, Viscido G, Gambardella G, di Bernardo D, Scudieri P, Galietta LJV. | 09/12/2020 |
| CFTR activation protects brain tissue against IR-induced apoptosis and oxidative stress. CFTR disruption enhances H2O2-induced neuronal apoptosis and CFTR loss leads to mitochondrial oxidative stress. CFTR regulates IR-induced neuronal apoptosis via mitochondrial oxidative stress. | CFTR prevents neuronal apoptosis following cerebral ischemia reperfusion via regulating mitochondrial oxidative stress.
Zhang YP, Zhang Y, Xiao ZB, Zhang YB, Zhang J, Li ZQ, Zhu YB. | 11/2/2019 |
| Intact CFTR (cystic fibrosis transmembrane conductance regulator) function is crucial for proper airway, pancreatic, and reproductive tract functions by regulating chloride and bicarbonate transport at the epithelial surface. | Maternal Smoking Induces Acquired CFTR Dysfunction in Neonatal Rats.
McCormick LL, Phillips SE, Kaza N, Tang LP, Rasmussen L, Byzek SA, Raju SV, Rowe SM., Free PMC Article | 09/14/2019 |
| The diverse phenotypes associated with CFTR mutations may be due to malfunction of CFTR at specific subcellular locations in the male reproductive system. | Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.
Sharma S, Hanukoglu I. | 05/4/2019 |
| Based on the nuclear localization of CFTR in rat testicles we suggest that, in addition to its role as an ion channel, CFTR may have an independent role in gene regulation within the nuclei. | Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa.
Sharma S, Hanukoglu A, Hanukoglu I. | 09/8/2018 |
| dexa induces a rapid stimulation of CFTR activity which depends on PI3K/AKT signaling in airway epithelial cells. Glucocorticoids might thus represent, in addition to their immunomodulatory actions, a therapeutic strategy to rapidly increase airway fluid secretion. | Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone.
Bossmann M, Ackermann BW, Thome UH, Laube M., Free PMC Article | 04/28/2018 |
| findings appear to be intrinsic to the CFTR deficient state and independent of significant clinical confounders, providing substantive evidence for the importance of CFTR on maintinaing normal bone growth | Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat.
Stalvey MS, Havasi V, Tuggle KL, Wang D, Birket S, Rowe SM, Sorscher EJ., Free PMC Article | 12/30/2017 |
| Increased levels of CFTR, adenylate cyclase and cAMP in cervix of rats treated with sex hormones and genistein could affect the cervical secretory function, influencing female reproductive processes. | Combinatorial effects of genistein and sex-steroids on the level of cystic fibrosis transmembrane regulator (CFTR), adenylate cyclase (AC) and cAMP in the cervix of ovariectomised rats.
Salleh N, Ismail N, Muniandy S, Korla PK, Giribabu N. | 10/1/2016 |
| increased abundance of CFTR, AC, and cAMP under estrogen influence could account for the increased fluid accumulation within the cervical lumen. | Estrogen and progesterone differentially regulate the levels of cystic fibrosis transmembrane regulator (CFTR), adenylate cyclase (AC), and cyclic adenosine mono-phosphate (cAMP) in the rat cervix.
Ismail N, Giribabu N, Muniandy S, Salleh N. | 03/26/2016 |
| CFTR Cl- channel is a molecular target of natural compounds EGCG and ECG. | Bioactivity-guided fractionation of an antidiarrheal Chinese herb Rhodiola kirilowii (Regel) Maxim reveals (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate as inhibitors of cystic fibrosis transmembrane conductance regulator.
Chen L, Yu B, Zhang Y, Gao X, Zhu L, Ma T, Yang H., Free PMC Article | 01/16/2016 |
| CFTR is involved in water homeostasis of the seminiferous tubular secretion. | Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator.
Jesus TT, Bernardino RL, Martins AD, Sá R, Sousa M, Alves MG, Oliveira PF. | 06/27/2015 |
| mRNA of the CFTR was expressed in the endolymphatic sac. Immunohistochemical analysis showed the expression of the CFTR on apical side of the endolymphatic sac epithelia and co-localization with the ENaC. | Cystic fibrosis transmembrane conductance regulator in the endolymphatic sac of the rat.
Matsubara A, Miyashita T, Inamoto R, Hoshikawa H, Mori N. | 06/20/2015 |
| CFTR may modulate oxidative stress-related basilar vascular smooth muscle cells apoptosis through the cAMP- and mitochondria-dependent pathway and regulating endogenous antioxidant defense system. | Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells.
Zeng JW, Zeng XL, Li FY, Ma MM, Yuan F, Liu J, Lv XF, Wang GL, Guan YY. | 04/4/2015 |
| Young CFTR-/- rats exhibited histological abnormalities in the ileum and increased intracellular mucus in the proximal nasal septa. | Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats.
Tuggle KL, Birket SE, Cui X, Hong J, Warren J, Reid L, Chambers A, Ji D, Gamber K, Chu KK, Tearney G, Tang LP, Fortenberry JA, Du M, Cadillac JM, Bedwell DM, Rowe SM, Sorscher EJ, Fanucchi MV., Free PMC Article | 02/28/2015 |
| Changes in CFTR protein manifestation in the hepatic ductal structures and renal tubules in experimental pregnancy cholestasis could aggravate the disease. | Manifestation of cystic fibrosis transmembrane regulator (CFTR) in hepatic ductal structures and renal tubules of female rats with experimental cholestasis of pregnancy.
Aleksandrova MI, Kushnareva NS, Smirnova OV. | 12/20/2014 |
| Exocrine pancreas with CFTRDeltaF508 mutation or endocrine CFTR-inhibited cells present susceptibility to P.Aeruginosa lipopolysaccharides . During recurrent infections exocrine Microparticles may contribute to endocrine cell dysfunction via NF-kappaB pathways. | Exocrine cell-derived microparticles in response to lipopolysaccharide promote endocrine dysfunction in cystic fibrosis.
Constantinescu AA, Gleizes C, Alhosin M, Yala E, Zobairi F, Leclercq A, Stoian G, Mitrea IL, Prévost G, Toti F, Kessler L. | 11/22/2014 |
| The co-immunoprecipitation experiments showed a direct interaction between AQP4 and CFTR in cultured rat Sertoli cells. | Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells.
Jesus TT, Bernardino RL, Martins AD, Sá R, Sousa M, Alves MG, Oliveira PF. | 06/28/2014 |
| Alveolar Cl(-) and fluid secretion are triggered by ENaC inhibition and mediated by NKCC and CFTR. | Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema.
Solymosi EA, Kaestle-Gembardt SM, Vadász I, Wang L, Neye N, Chupin CJ, Rozowsky S, Ruehl R, Tabuchi A, Schulz H, Kapus A, Morty RE, Kuebler WM., Free PMC Article | 09/7/2013 |