| Stimulation of the calcium-sensing receptor induces relaxations of rat mesenteric arteries by endothelium-dependent and -independent pathways via BKCa and KATP channels. | Stimulation of the calcium-sensing receptor induces relaxations of rat mesenteric arteries by endothelium-dependent and -independent pathways via BK(Ca) and K(ATP) channels.
Carlton-Carew SRE, Greenberg HZE, Connor EJ, Zadeh P, Greenwood IA, Albert AP., Free PMC Article | 02/29/2024 |
| Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats. | Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats.
Li RJW, Barros DR, Kuah R, Lim YM, Gao A, Beaudry JL, Zhang SY, Lam TKT. | 02/4/2024 |
| Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility. | Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility.
Liu B, Wei YP, Fan X, Hu X, Chen Z, Liu X, Xu Y, Wang L, Wang T, Ruiz M, Dupuis J, Yuan P, Liu J, Huang S, Zhu L, Jing ZC, Hu Q. | 06/18/2022 |
| Decreased monocyte calcium sensing receptor expression in patients with chronic kidney disease is associated with impaired monocyte ability to reduce vascular calcification. | Decreased monocyte calcium sensing receptor expression in patients with chronic kidney disease is associated with impaired monocyte ability to reduce vascular calcification.
Mary A, Objois T, Brazier M, Bennis Y, Boudot C, Lenglet G, Paccou J, Bugnicourt JM, Choukroun G, Drueke TB, Massy ZA, Kamel S, Six I, Mentaverri R. | 07/17/2021 |
| Astragaloside IV attenuates cerebral ischemiareperfusion injury in rats through the inhibition of calciumsensing receptormediated apoptosis. | Astragaloside IV attenuates cerebral ischemia‑reperfusion injury in rats through the inhibition of calcium‑sensing receptor‑mediated apoptosis.
Du SJ, Zhang Y, Zhao YM, Dong YJ, Tang JL, Zhou XH, Gao WJ., Free PMC Article | 07/17/2021 |
| CaSR is required for ischemia-induced proliferation and differentiation of white matter progenitor cells from neonatal rats. | CaSR is required for ischemia-induced proliferation and differentiation of white matter progenitor cells from neonatal rats.
Mao FX, Luo CH, Chen HJ, Zhang YX, Zhang Q. | 06/12/2021 |
| Activation of calciumsensing receptormediated autophagy in high glucoseinduced cardiac fibrosis in vitro. | Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro.
Yuan H, Xu J, Zhu Y, Li L, Wang Q, Yu Y, Zhou B, Liu Y, Xu X, Wang Z., Free PMC Article | 04/24/2021 |
| tudy revealed a novel pathological action of CaSR in development of osteoarthritic cartilage due to aberrant mechanical stimuli and supports a therapeutic potential of calcilytics in preventing osteoarthritis in temporomandibular joints by targeting the CaSR. | Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR.
Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, Ye T, Liu Q, Xie M, Liu X, Yu S, Guo S, Chang W, Wang M., Free PMC Article | 07/18/2020 |
| cardiac CaSRs do not activate Gi and affect GIRK currents preferentially via the Gq/PKC pathway. | Biased signaling of Ca(2+)-sensing receptors in cardiac myocytes regulates GIRK channel activity.
Kienitz MC, Niemeyer A, König GM, Kostenis E, Pott L, Rinne A. | 06/20/2020 |
| The combined effects of CaSR antagonists with imatinib on the development of pulmonary hypertension were examined in monocrotaline-induced pulmonary hypertensive rats. The up-regulation of CaSR was reduced by imatinib. | Platelet-derived growth factor up-regulates Ca(2+)-sensing receptors in idiopathic pulmonary arterial hypertension.
Yamamura A, Nayeem MJ, Al Mamun A, Takahashi R, Hayashi H, Sato M. | 05/23/2020 |
| CaSR inhibition with the negative allosteric modulator Calhex231 or CaSR knockdown attenuates cigarette smoke-induced pulmonary hypertension in rats. CaSR knockdown profoundly suppresses eEV exposure-mobilized cytosolic calcium signaling, pulmonary artery constriction, and smooth muscle cell proliferation. CaSR knockout results in attenuated development of pulmonary hypertension induced by an intravascular administration. | Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.
Zhu L, Xiao R, Zhang X, Lang Y, Liu F, Yu Z, Zhang J, Su Y, Lu Y, Wang T, Luo S, Wang J, Liu ML, Dupuis J, Jing ZC, Li T, Xiong W, Hu Q. | 01/18/2020 |
| These results confirmed that CaSR activated PKCdelta to induce cardiomyocyte apoptosis through ER stressassociated apoptotic pathways during I/R in vivo. | CaSR activates PKCδ to induce cardiomyocyte apoptosis via ER stress‑associated apoptotic pathways during ischemia/reperfusion.
Liu C, Li H, Zheng H, Zhai M, Lu F, Dong S, Fang T, Zhang W. | 01/11/2020 |
| Calcium-sensing receptor promotes high glucose-induced myocardial fibrosis via upregulation of the TGF-beta1/Smads pathway in rat cardiac fibroblasts. The increase of CaSR expression in rat cardiac fibroblasts (CFs) may induce intracellular Ca2+ increases and the activation of TGF-beta1/Smads, and enhance the proliferation of CFs, along with the excessive deposition of Col, resulting in myocardial fibrosis. | Calcium‑sensing receptor promotes high glucose‑induced myocardial fibrosis via upregulation of the TGF‑β1/Smads pathway in cardiac fibroblasts.
Yuan H, Fan Y, Wang Y, Gao T, Shao Y, Zhao B, Li H, Xu C, Wei C., Free PMC Article | 01/4/2020 |
| CaSR was detected in rat cornea, lens, and retina. It was significantly decreased in the eyes of diabetic rats. | The Expression of Calcium Sensing Receptor in Normal and Diabetic Rat Eyes.
Jiang P, Huang R, Ma N, Jiang F., Free PMC Article | 08/18/2018 |
| CaSR activation results in intracellular calcium release, MEK1/2 pathway phosphorylation, autophagy activation and collagen formation induced by AngII in cardiac fibroblasts. | Activation of calcium-sensing receptor-mediated autophagy in angiotensinII-induced cardiac fibrosis in vitro.
Chi J, Wang L, Zhang X, Fu Y, Liu Y, Chen W, Liu W, Shi Z, Yin X. | 04/7/2018 |
| these results suggest that high glucose induces myocardial energy metabolism disorder via decrease of CaSR expression, and activation of gp78-ubiquitin proteasome system. | Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.
Wang Y, Gao P, Wei C, Li H, Zhang L, Zhao Y, Wu B, Tian Y, Zhang W, Wu L, Wang R, Xu C., Free PMC Article | 03/3/2018 |
| Calcium sensing receptor (CaSR) was increased in the aortas from spontaneous hypertensive rats (SHRs) compared with age-matched Wistar Kyoto (WKY) rats. | Involvement of mitochondrial fission in calcium sensing receptor-mediated vascular smooth muscle cells proliferation during hypertension.
Zhang X, Chen W, Li J, Qi S, Hong S, Wang Y, Gao L, Shi Z, Liu Y, Liu W, Chi Y, Liu C, Fu Y, Yin X. | 01/6/2018 |
| These findings indicate that cardiac function could be enhanced significantly by combination therapy with CaSR inhibition and ESC transplantation; the effect was better than ESC transplantation alone, and the mechanism might be associated with a reduction in cell apoptosis via the inhibition of the MAPK pathway. | Calcium-sensing receptor-mediated mitogen-activated protein kinase pathway improves the status of transplanted mouse embryonic stem cells in rats with acute myocardial infarction.
Sun J, Wei T, Bai S, Zhao H, Liu X, Yu J, Li L, Song G, Luan H, Xu C. | 12/9/2017 |
| Monocrotaline aggregates on and activates the CaSR of pulmonary artery endothelial cells to trigger endothelial damage and, ultimately, induces pulmonary hypertension. | Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor.
Xiao R, Su Y, Feng T, Sun M, Liu B, Zhang J, Lu Y, Li J, Wang T, Zhu L, Hu Q., Free PMC Article | 10/28/2017 |
| ET-1 causes an adaptive type of hypertrophy by up-regulation of CaR in cardiomyocytes via ETA and/or ETB1 receptors. | The Role of Calcium-Sensing Receptors in Endothelin-1-Dependent Effects on Adult Rat Ventricular Cardiomyocytes: Possible Contribution to Adaptive Myocardial Hypertrophy.
Dyukova E, Schreckenberg R, Arens C, Sitdikova G, Schlüter KD. | 08/12/2017 |
| reduced expression of the CaSR is correlated with activation of the renin-angiotensin system, which induces increased vascular remodeling and vascular smooth muscle cell proliferation, and thereby associated with essential hypertension in the SHR rat model and in the Han Chinese population | Reduced Expression of the Extracellular Calcium-Sensing Receptor (CaSR) Is Associated with Activation of the Renin-Angiotensin System (RAS) to Promote Vascular Remodeling in the Pathogenesis of Essential Hypertension.
Qu YY, Hui J, Wang LM, Tang N, Zhong H, Liu YM, Li Z, Feng Q, He F., Free PMC Article | 08/5/2017 |
| VS-105 exerts a rapid effect on suppressing serum PTH, directly down-regulates the PTH gene, and modulates PTH, VDR and CaSR gene expression more effectively than paricalcitol | Vitamin D receptor agonist VS-105 directly modulates parathyroid hormone expression in human parathyroid cells and in 5/6 nephrectomized rats.
Sawada K, Wu-Wong JR, Chen YW, Wessale JL, Kanai G, Kakuta T, Fukagawa M. | 07/8/2017 |
| Our results demonstrated that CaSR activation induced cardiomyocyte apoptosis through the mitochondrial dynamics mediated apoptotic pathway in hypertensive hearts. | Role of the calcium sensing receptor in cardiomyocyte apoptosis via mitochondrial dynamics in compensatory hypertrophied myocardium of spontaneously hypertensive rat.
Hong S, Zhang X, Zhang X, Liu W, Fu Y, Liu Y, Shi Z, Chi J, Zhao M, Yin X. | 06/24/2017 |
| The results showed that the [Ca(2+)]i and the expression of p-CaMK and CSE increased upon treatment with CaSR agonist. | Inhibition of hydrogen sulfide on the proliferation of vascular smooth muscle cells involved in the modulation of calcium sensing receptor in high homocysteine.
Wang Y, Wang X, Liang X, Wu J, Dong S, Li H, Jin M, Sun D, Zhang W, Zhong X. | 05/20/2017 |
| Results demonstrate that selective and long-lasting astroglial induction of CaSR expression is a common characteristic of ischemic brain injury and suggest its involvement in the ischemia-induced astroglial reaction | Enhanced expression of the calcium-sensing receptor in reactive astrocytes following ischemic injury in vivo and in vitro.
Pak HJ, Riew TR, Shin YJ, Choi JH, Jin X, Lee MY. | 04/29/2017 |