| Assessing the Role of Calmodulin's Linker Flexibility in Target Binding. | Assessing the Role of Calmodulin's Linker Flexibility in Target Binding.
Sun B, Kekenes-Huskey PM., Free PMC Article | 06/19/2021 |
| Distinct roles of calmodulin and Ca(2+)/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy. | Distinct roles of calmodulin and Ca(2+)/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy.
Wang S, Li J, Liu Y, Zhang J, Zheng X, Sun X, Lei S, Kang Z, Chen X, Lei M, Hu H, Zeng X, Hao L. | 11/28/2020 |
| Tau could inhibit the H2O2-induced decrease in CamKII and CaM expression at both the mRNA and protein levels. | Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide.
Wang J, Qi C, Liu L, Zhao L, Cui W, Tian Y, Liu B, Li J. | 02/10/2018 |
| These results suggest a connection between Ca(2+)-signaling via excitation-contraction coupling and the regulation of STARS-mediated gene expression in muscles. | Identification of striated muscle activator of Rho signaling (STARS) as a novel calmodulin target by a newly developed genome-wide screen.
Furuya Y, Denda M, Sakane K, Ogusu T, Takahashi S, Magari M, Kanayama N, Morishita R, Tokumitsu H. | 09/30/2017 |
| Hydrogen peroxide reduces calmodulin binding to RYR2 in rat cardiomyocytes. | Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.
Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM., Free PMC Article | 05/21/2016 |
| Disruption of calmodulin binding to KCNQ2 also impairs enrichment of heteromeric KCNQ2/KCNQ3 channels at the axonal surface by blocking their trafficking from the endoplasmic reticulum to the axon. | Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit.
Cavaretta JP, Sherer KR, Lee KY, Kim EH, Issema RS, Chung HJ., Free PMC Article | 11/14/2015 |
| Study reveals that apoCaM itself prominently regulates both voltage-gated Ca2+ and Na channels; ApoCaM binding to these channels enhances opening several-fold, matching the strongest forms of ion-channel regulation. | Apocalmodulin itself promotes ion channel opening and Ca(2+) regulation.
Adams PJ, Ben-Johny M, Dick IE, Inoue T, Yue DT., Free PMC Article | 03/21/2015 |
| The molecular events underlying the association between CaM and Kv7.2 and their regulation by Ca(2+), was examined. | Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.
Alaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Bernardo-Seisdedos G, Malo C, Millet O, Areso P, Villarroel A., Free PMC Article | 12/27/2014 |
| The study proposes that the structural basis of calcineurin activation by calmodulin is through displacement of the disordered fragment of the autoinhibitory domain which otherwise impedes active site access. | Structural basis of calcineurin activation by calmodulin.
Ye Q, Feng Y, Yin Y, Faucher F, Currie MA, Rahman MN, Jin J, Li S, Wei Q, Jia Z. | 12/6/2014 |
| Recombinant small (SK2) calcium channel and calmodulin bind with three different stoichiometries that depend on the molar ratio of 2SKp/2CaM in solution. | Calcium-dependent stoichiometries of the KCa2.2 (SK) intracellular domain/calmodulin complex in solution.
Halling DB, Kenrick SA, Riggs AF, Aldrich RW., Free PMC Article | 10/18/2014 |
| CK2-mediated phosphorylation of calmodulin regulates the M-current, which is tonically regulated by CK2 and PP1 anchored to the KCNQ2 channel complex. | Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin.
Kang S, Xu M, Cooper EC, Hoshi N., Free PMC Article | 06/7/2014 |
| GRK5 nuclear translocation downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process | Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.
Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ., Free PMC Article | 12/7/2013 |
| Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin. | Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.
Lefèvre J, Savarin P, Gans P, Hamon L, Clément MJ, David MO, Bosc C, Andrieux A, Curmi PA., Free PMC Article | 11/16/2013 |
| Data indicate that the two distinct CaM/OLFp complexes existed simultaneously with stable structures. | Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel.
Irene D, Huang JW, Chung TY, Li FY, Tzen JT, Lin TH, Chyan CL. | 08/31/2013 |
| structures of intact calmodulin (CaM)-free and CaM-bound endothelial nitric oxide synthase (eNOS) | Calmodulin-induced structural changes in endothelial nitric oxide synthase.
Persechini A, Tran QK, Black DJ, Gogol EP., Free PMC Article | 03/23/2013 |
| Sustained Epac activation induces a strong positive inotropic effect relating to enhanced calcium signaling and increased expression of calmodulin. | Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes.
Ruiz-Hurtado G, Domínguez-Rodríguez A, Pereira L, Fernández-Velasco M, Cassan C, Lezoualc'h F, Benitah JP, Gómez AM. | 03/23/2013 |
| Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation. | Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation.
Zhong L, Gerges NZ., Free PMC Article | 03/16/2013 |
| The crystal structure of a CaM.Orai1-calmodulin binding domain complex, is reported. | Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode.
Liu Y, Zheng X, Mueller GA, Sobhany M, DeRose EF, Zhang Y, London RE, Birnbaumer L., Free PMC Article | 02/16/2013 |
| Cx32 is differentially phosphorylated and exists in a complex with SAP97 and CaM. | Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin.
Stauch K, Kieken F, Sorgen P., Free PMC Article | 11/17/2012 |
| Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a. | Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
Lu Z, Shen M, Cao Y, Zhang HM, Yao LL, Li XD., Free PMC Article | 07/14/2012 |
| In PMCA-suppressed lines total CaM increased, and the calm I and calm II genes appeared to be responsible for this effect | Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin.
Boczek T, Kozaczuk A, Ferenc B, Kosiorek M, Pikula S, Zylinska L. | 03/24/2012 |
| Calmodulin facilitates endocytosis in an activity-dependent manner. | Activity-dependent modulation of endocytosis by calmodulin at a large central synapse.
Yao L, Sakaba T., Free PMC Article | 03/10/2012 |
| PKC and CaM protein expressions were downregulated in the hippocampus of neonatal rats exposed to lead. | [Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus of baby-rats].
Liu ZH, Zhang JS, Wang FS, Liu KM, Shang BD, Guan T, Di JR, Tian Y. | 03/3/2012 |
| Both the location and orientation of CaM binding on the RyR2 are very similar to the skeletal muscle RyR1 isoform. | FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel.
Guo T, Fruen BR, Nitu FR, Nguyen TD, Yang Y, Cornea RL, Bers DM., Free PMC Article | 03/3/2012 |
| PKC and CaM mRNA expression was downregulated in the hippocampus of baby rats with chronic lead exposure. | [Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus and neurobehavioral function of baby rats].
Wang FS, Liu ZH, Zhang JS, Di JR. | 01/28/2012 |