| [Estradiol regulates the expression of plasma membrane Ca[2+]-ATPase isoform 2 in inner ear of rats]. | [Estradiol regulates the expression of plasma membrane Ca(2+)-ATPase isoform 2 in inner ear of rats].
Tian Q, Feng MY, Gu HH, Zhang ZH, Qian SX, Zhuang JH. | 02/4/2023 |
| Although modification of PMCAs composition could provide some protection against calcium overload, reduction of PMCA2 appeared to be more detrimental to the cells than deficiency of PMCA3. Under pathological conditions, including inflammatory CCL5 action and long-lasting Ca(2+) dyshomeostasis, insufficient cell protection may result in progressive degeneration and death of neurons. | Calcium Dyshomeostasis Alters CCL5 Signaling in Differentiated PC12 Cells.
Radzik T, Boczek T, Ferenc B, Studzian M, Pulaski L, Zylinska L., Free PMC Article | 08/24/2019 |
| higher occupancy of Calm2 and Calm3 promoters by NFATc2 and increased expression of these genes in response to NFATc2 silencing were demonstrated in PMCA2 and PMCA3-reduced lines. | Cross talk among PMCA, calcineurin and NFAT transcription factors in control of calmodulin gene expression in differentiating PC12 cells.
Boczek T, Lisek M, Ferenc B, Zylinska L. | 06/24/2017 |
| The results with PMCA2- or PMCA3-downregulated lines provide an evidence of a novel role of PMCA isoforms in regulation of bioenergetic pathways. | Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells.
Boczek T, Lisek M, Ferenc B, Kowalski A, Wiktorska M, Zylinska L., Free PMC Article | 06/20/2015 |
| GlyT2 activity is pre-synaptically controlled by physical and functional association with plasma membrane PMCA2, PMCA3, and NCX1. | Presynaptic control of glycine transporter 2 (GlyT2) by physical and functional association with plasma membrane Ca2+-ATPase (PMCA) and Na+-Ca2+ exchanger (NCX).
de Juan-Sanz J, Núñez E, Zafra F, Berrocal M, Corbacho I, Ibáñez I, Arribas-González E, Marcos D, López-Corcuera B, Mata AM, Aragón C., Free PMC Article | 03/7/2015 |
| Plasma membrane PMCA2 and PMCA3 regulate cellular pH homeostasis in differentiating adrenal chromaffin cell line in a manner dependent on cytosolic Ca2+ elevations. | Plasma membrane Ca2+-ATPase isoforms composition regulates cellular pH homeostasis in differentiating PC12 cells in a manner dependent on cytosolic Ca2+ elevations.
Boczek T, Lisek M, Ferenc B, Kowalski A, Stepinski D, Wiktorska M, Zylinska L., Free PMC Article | 03/7/2015 |
| Results demonstrate a significant impairment of cell survival under conditions of PMCA2 suppression. Overexpression of PMCA2 rendered the neurons significantly resistant to complex I inhibition. | Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition.
Brendel A, Renziehausen J, Behl C, Hajieva P. | 09/20/2014 |
| The distribution of PMCA2 at different cochlear locations during development was quantified. | The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.
Chen Q, Mahendrasingam S, Tickle JA, Hackney CM, Furness DN, Fettiplace R., Free PMC Article | 12/8/2012 |
| Results suggest that PMCA2 and PMCA3 function is rather related to regulation of GABA synthesis and degradation than supplying cells with metabolites, which can be potentially energetic source. | GABA-shunt enzymes activity in GH3 cells with reduced level of PMCA2 or PMCA3 isoform.
Kowalski A, Zylińska L, Boczek T, Rębas E. | 10/15/2011 |
| Spiral ganglion cells from newborn rats strongly expresses PMCA2. | [Expression of plasma membrane Ca²(+)-ATPase isoform 2 in spiral ganglion cells of newborn rats].
Chen QG, Chu HQ, Wang XH, Chen J, Li JL, Cui YH. | 05/21/2011 |
| Data link the reduction in PMCA2 expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE. | Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.
Kurnellas MP, Li H, Jain MR, Giraud SN, Nicot AB, Ratnayake A, Heary RF, Elkabes S., Free PMC Article | 01/15/2011 |
| A novel function for PMCAs as modulators of Ca(2+) signaling at the synapse is suggested. | A plasma membrane Ca2+ ATPase isoform at the postsynaptic density.
Burette AC, Strehler EE, Weinberg RJ., Free PMC Article | 01/1/2011 |
| Changes in islet plasma membrane calcium ATPase activity and Atp2b2 protein isoform expression induced by insulin reistance are reported. | Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance.
Alzugaray ME, García ME, Del Zotto HH, Raschia MA, Palomeque J, Rossi JP, Gagliardino JJ, Flores LE. | 01/21/2010 |
| Reduced expression of PMCA2a during homeostatic plasticity provides a mechanism to remodel pre-synaptic Ca2+ dynamics as a flexible way to alter glutamate release. | Reduced expression of the "fast" calcium transporter PMCA2a during homeostatic plasticity.
Jensen TP, Buckby LE, Empson RM. | 01/21/2010 |
| overexpression of PMCA2 leads, in insulin-producing cells, to an imbalance between ATP generation and consumption. | Effects of plasma membrane Ca(2+)-ATPase overexpression upon D-glucose metabolism in insulin-producing BRIN-BD11 cells.
Kamagate A, Sener A, Courtois P, Malaisse WJ, Herchuelz A. | 01/21/2010 |
| Results suggest that the fast Ca(2+) activation kinetics and high V(max) of PMCA2a make this pump especially suited for rapid clearance of presynaptic Ca(2+) in fast-spiking inhibitory nerve terminals, which face severe transient calcium loads. | "Fast" plasma membrane calcium pump PMCA2a concentrates in GABAergic terminals in the adult rat brain.
Burette AC, Strehler EE, Weinberg RJ., Free PMC Article | 01/21/2010 |
| Results indicate that hormones affected Ca(2+) transport activity via PMCA2, and that this effect depended on both PMCA isoform composition and steroid structure. | Fast action of neuroactive steroids on plasma membrane calcium pump in PC12 cells.
Zylinska L, Kowalska I, Kozaczuk A. | 01/21/2010 |
| The evidence suggests that PMCA contributes to re-establish resting Ca(2+) levels in the cilia following olfactory responses. | Plasma membrane Ca(2+)-ATPase in the cilia of olfactory receptor neurons: possible role in Ca(2+) clearance.
Castillo K, Delgado R, Bacigalupo J. | 01/21/2010 |
| PMCA2 molecules maintain transient interactions with other components of stereocilia, and mobile pool of PMCA2 mediates exchange between stereocilia and removal and delivery sites at periphery of apical cell surface. | Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2.
Grati M, Schneider ME, Lipkow K, Strehler EE, Wenthold RJ, Kachar B., Free PMC Article | 01/21/2010 |
| PMCA2 is targeted to distinct compartments within the plasma membrane. In the molecular layer, this isoform was at highest levels within postsynaptic profiles of the cerebellar cortex. | Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex.
Burette A, Weinberg RJ. | 01/21/2010 |
| fast PMCA2a-mediated clearance of [Ca2+]i from presynaptic excitatory terminals regulated excitatory synaptic transmission within hippocampal CA3 | Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3.
Jensen TP, Filoteo AG, Knopfel T, Empson RM., Free PMC Article | 01/21/2010 |
| A Leu-Ile motif in 'b'-tail splice variants promotes PMCA1b and PMCA2b basolateral sorting in hair cells. | Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells.
Grati M, Aggarwal N, Strehler EE, Wenthold RJ. | 01/21/2010 |
| PMCA2w/a is hair-bundle isoform of PMCA in rat hair cells, and splice variant 2w targets PMCA2 to bundles. The 2w sequence is first targeting signal identified for a hair-bundle membrane protein | Splice-site A choice targets plasma-membrane Ca2+-ATPase isoform 2 to hair bundles.
Hill JK, Williams DE, LeMasurier M, Dumont RA, Strehler EE, Gillespie PG., Free PMC Article | 01/21/2010 |