| Chemokine CCL19 promotes type 2 T-cell differentiation and allergic airway inflammation. | Chemokine CCL19 promotes type 2 T-cell differentiation and allergic airway inflammation.
Nakano K, Whitehead GS, Lyons-Cohen MR, Grimm SA, Wilkinson CL, Izumi G, Livraghi-Butrico A, Cook DN, Nakano H., | 02/9/2024 |
| The Important Role of the Chemokine Axis CCR7-CCL19 and CCR7-CCL21 in the Pathophysiology of the Immuno-inflammatory Response in Dry Eye Disease. | The Important Role of the Chemokine Axis CCR7-CCL19 and CCR7-CCL21 in the Pathophysiology of the Immuno-inflammatory Response in Dry Eye Disease.
Wang T, Li W, Cheng H, Zhong L, Deng J, Ling S. | 12/4/2021 |
| CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge. | CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge.
Yan Y, Hu K, Fu M, Deng X, Luo S, Tong L, Guan X, He S, Li C, Jin W, Du T, Zheng Z, Zhang M, Liu Y, Hu Q., Free PMC Article | 10/30/2021 |
| IRF-1 contributes to the pathological phenotype of VSMCs during atherogenesis by increasing CCL19 transcription. | IRF-1 contributes to the pathological phenotype of VSMCs during atherogenesis by increasing CCL19 transcription.
Shen Y, Sun Z, Mao S, Zhang Y, Jiang W, Wang H., Free PMC Article | 05/15/2021 |
| Astrocyte-derived CCL19 was required for age-related gliosis-induced central nervous system lymphoma (CNSL). Deleting CCL19 in mice or CCR7 from lymphoma cells (LCs) abrogated CNSL development. Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild-type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL. | Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M. | 05/23/2020 |
| CCL19-expressing fibroblastic stromal cells in murine lung carcinoma control tumor growth | CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses.
Cheng HW, Onder L, Cupovic J, Boesch M, Novkovic M, Pikor N, Tarantino I, Rodriguez R, Schneider T, Jochum W, Brutsche M, Ludewig B. | 09/21/2019 |
| Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis. | Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis.
Hua J, Stevenson W, Dohlman TH, Inomata T, Tahvildari M, Calcagno N, Pirmadjid N, Sadrai Z, Chauhan SK, Dana R., Free PMC Article | 04/22/2019 |
| We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 x 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs... Following treatment of mice with 7 x 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors. | IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor.
Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K. | 12/22/2018 |
| These data show that CCR7-CCL19/CCL21 axis facilitates retention CD4(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis. | CCR7-CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia.
Nossent AY, Bastiaansen AJ, Peters EA, de Vries MR, Aref Z, Welten SM, de Jager SC, van der Pouw Kraan TC, Quax PH., Free PMC Article | 02/17/2018 |
| the white pulp regions of ME7-infected spleens were smaller, and contained markedly diminished T zones, as compared to control spleens. Although lymphoid tissue inducer cells were not affected, the expression of both CCL19 and CCL21 was decreased. | Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice.
Kim S, Han S, Lee HS, Kim YS, Choi EK, Kim MY. | 12/2/2017 |
| a comprehensive model of CCL19 and CCL21 transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream | A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.
Jafarnejad M, Zawieja DC, Brook BS, Nibbs RJB, Moore JE Jr., Free PMC Article | 10/28/2017 |
| The beneficial effects of epicatechin in ameriorating diet-induced obesity and insulin resistance could be mediated, at least in part, by marked suppression of CCL19 expression. | Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance.
Sano T, Nagayasu S, Suzuki S, Iwashita M, Yamashita A, Shinjo T, Sanui T, Kushiyama A, Kanematsu T, Asano T, Nishimura F. | 09/9/2017 |
| Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 and CCL21, as well as on the nuclear factor-Kappa B (NF-kappaB) pathway in a mouse model of asthma. | Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21.
Liu J, Wei Y, Luo Q, Xu F, Zhao Z, Zhang H, Lu L, Sun J, Liu F, Du X, Li M, Wei K, Dong J. | 03/25/2017 |
| increased expression in mononuclear inflammatory cells isolated from the brain during active stage of experimental autoimmune encephalomyelitis | Central Nervous System and Peripheral Expression of CCL19, CCL21 and Their Receptor CCR7 in Experimental Model of Multiple Sclerosis.
Bielecki B, Jatczak-Pawlik I, Wolinski P, Bednarek A, Glabinski A., Free PMC Article | 06/28/2016 |
| Interferon-gamma (IFN-gamma) and interleukin-12 (IL-12) levels in the tumors and plasma were significantly enhanced after processing with recombinant mouse CCL19. | CC motif chemokine ligand 19 suppressed colorectal cancer in vivo accompanied by an increase in IL-12 and IFN-γ.
Lu J, Ma J, Cai W, Wangpu X, Feng H, Zhao J, Guan S, Zong Y, Lu A. | 10/17/2015 |
| Modulation of the chemokines CCL19 and CCL21 represents a potent immunoregulatory treatment approach, and thus represents a novel therapeutic target to stabilize atherosclerotic lesions. | CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions.
Akhavanpoor M, Gleissner CA, Gorbatsch S, Doesch AO, Akhavanpoor H, Wangler S, Jahn F, Lasitschka F, Katus HA, Erbel C., Free PMC Article | 08/15/2015 |
| CCL19 (ELC) improves TH1-polarized immune responses and protective immunity in a murine Her2/neu DNA vaccination model. | CCL19 (ELC) improves TH1-polarized immune responses and protective immunity in a murine Her2/neu DNA vaccination model.
Nguyen-Hoai T, Baldenhofer G, Ahmed MS, Pham-Duc M, Gries M, Lipp M, Dörken B, Pezzutto A, Westermann J. | 07/14/2012 |
| study shows that CCL19/21 and its possible signaling through CXCR3 are required for the development of thymic metallophilic macrophages | Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus.
Milićević NM, Miljković MD, Milićević Z, Labudović-Borović M, Wang X, Laan M, Peterson P, Randall TD, Westermann J., Free PMC Article | 11/5/2011 |
| CCL19 and CCL21 induce prompt Ab responses to antigen, and negatively regulate helper T cell responses in vivo. | Altered antibody production and helper T cell function in mice lacking chemokines CCL19 and CCL21-Ser.
Aritomi K, Kuwabara T, Tanaka Y, Nakano H, Yasuda T, Ishikawa F, Kurosawa H, Kakiuchi T. | 01/8/2011 |
| CCX-CKR(-/-) have a 5-fold increase in the level of CCL21 protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 in peripheral lymph nodes. | The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses.
Comerford I, Nibbs RJ, Litchfield W, Bunting M, Harata-Lee Y, Haylock-Jacobs S, Forrow S, Korner H, McColl SR. | 01/1/2011 |
| Complete deficiency of CCL19 & CCL21 but not CCL19 alone was associated with abnormal frequencies & localization of DC in naive lymph nodes. CCL19 was not required for DC migration from the skin, full DC maturation or efficient T-cell priming. | CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19.
Britschgi MR, Favre S, Luther SA. | 06/28/2010 |
| Systemic delivery of an immune-activating signal using CCL19 transduced embryonic endothelial progenitor cells suppresses metastasis of murine ovarian cancer. | Activated local immunity by CC chemokine ligand 19-transduced embryonic endothelial progenitor cells suppresses metastasis of murine ovarian cancer.
Hamanishi J, Mandai M, Matsumura N, Baba T, Yamaguchi K, Fujii S, Konishi I. | 03/8/2010 |
| CCL19 homeostatic chemokine performs distinct functions that cooperate with CCL21 and CXCL13 to mediate effective expression of immunity against Mycobacterium tuberculosis infection. | In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity.
Khader SA, Rangel-Moreno J, Fountain JJ, Martino CA, Reiley WW, Pearl JE, Winslow GM, Woodland DL, Randall TD, Cooper AM., Free PMC Article | 02/15/2010 |
| cigarette smoke induces pulmonary expression of lymphoid chemokines CXCL13 and CCL19 in a LTalphabeta-LTbetaR-dependent fashion | Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis.
Demoor T, Bracke KR, Maes T, Vandooren B, Elewaut D, Pilette C, Joos GF, Brusselle GG. | 01/21/2010 |
| CCR7 ligands CCL19 and CCL21 have novel roles in the generation of T helper (Th)17 cells and in the induction of experimental autoimmune encephalitis. | CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells.
Kuwabara T, Ishikawa F, Yasuda T, Aritomi K, Nakano H, Tanaka Y, Okada Y, Lipp M, Kakiuchi T. | 01/21/2010 |