| MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression. | MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
Luiz JPM, Toller-Kawahisa JE, Viacava PR, Nascimento DC, Pereira PT, Saraiva AL, Prado DS, LeBert M, Giurisato E, Tournier C, Cunha TM, Cunha FQ, Quesniaux V, Ryffel B, Alves-Filho JC. | 02/13/2021 |
| MEK5 promotes lung adenocarcinoma. | MEK5 promotes lung adenocarcinoma.
Sánchez-Fdez A, Ortiz-Ruiz MJ, Re-Louhau MF, Ramos I, Blanco-Múñez Ó, Ludeña D, Abad M, Sánchez-Martín M, Pandiella A, Esparís-Ogando A., Free PMC Article | 10/31/2020 |
| These results suggest that YAP promotes muscle differentiation by activating the Abl/Src/MEKK3/MEK5/ERK5 kinase cascade. | YAP promotes myogenic differentiation via the MEK5-ERK5 pathway.
Chen TH, Chen CY, Wen HC, Chang CC, Wang HD, Chuu CP, Chang CH. | 09/23/2017 |
| MEK5 overexpression inhibits differentiation of osteoblasts. | MEK5 suppresses osteoblastic differentiation.
Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C. | 09/12/2015 |
| the MEK5-ERK5 MAP kinase signaling pathway has a critical role in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers | BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
Jacque E, Schweighoffer E, Tybulewicz VL, Ley SC., Free PMC Article | 08/15/2015 |
| The MEK5/ERK5 pathway also mediates FSS-induced Runx-2 expression in osteoblast differentiation. | The MEK5/ERK5 pathway mediates fluid shear stress promoted osteoblast differentiation.
Zhao LG, Chen SL, Teng YJ, An LP, Wang J, Ma JL, Xia YY. | 10/25/2014 |
| finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression | REST and its downstream molecule Mek5 regulate survival of primordial germ cells.
Okamura D, Mochizuki K, Taniguchi H, Tokitake Y, Ikeda M, Yamada Y, Tournier C, Yamaguchi S, Tada T, Schöler HR, Matsui Y. | 02/23/2013 |
| Transfection of myoblasts with dominant-negative MEK5 blocked the pro-myogenic action of IGF-2. | MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.
Carter EJ, Cosgrove RA, Gonzalez I, Eisemann JH, Lovett FA, Cobb LJ, Pell JM., Free PMC Article | 01/21/2010 |
| Results show the critical involvement of the MEK5-ERK5 pathway in thymocyte development distinct from that of ERK1/2 and highlight the importance of the MAPK network in mediating differential effects pertaining to T-cell differentiation and apoptosis. | Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis.
Sohn SJ, Lewis GM, Winoto A., Free PMC Article | 01/21/2010 |
| MEK5 and big MAP kinase 1 (BMK1) function downstream of MEKK3 in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 | Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1.
Abbasi S, Lee JD, Su B, Chen X, Alcon JL, Yang J, Kellems RE, Xia Y. | 01/21/2010 |
| MEK5 is an activator of ERK5 and an essential regulator of cell survival that is required for normal embryonic development | Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway.
Wang X, Merritt AJ, Seyfried J, Guo C, Papadakis ES, Finegan KG, Kayahara M, Dixon J, Boot-Handford RP, Cartwright EJ, Mayer U, Tournier C., Free PMC Article | 01/21/2010 |
| the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 signaling pathway | A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway.
Seyfried J, Wang X, Kharebava G, Tournier C., Free PMC Article | 01/21/2010 |
| PB1 domain mediates the association of MEKK2 and MEKK3 with MEK5 and that the respective PB1 domains of these kinases are critical for regulation of the ERK5 pathway. | PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.
Nakamura K, Johnson GL. | 01/21/2010 |
| A noncanonical function of Map2k5 domain is decribed for coordinated erk5 kinase and map2k7 signaling. | Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling.
Nakamura K, Johnson GL., Free PMC Article | 01/21/2010 |