| CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet. | CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet.
Guan H, Wang L, Geng Z, Duan B, Gao Y, Liang Z, Zheng X, Shi T, Guo F. | 07/24/2024 |
| CTRP 9 mitigates the apoptosis and unfolded protein response of OGD/R-induced retinal ganglion cells by regulating the AMPK pathway. | CTRP 9 mitigates the apoptosis and unfolded protein response of OGD/R-induced retinal ganglion cells by regulating the AMPK pathway.
Yang X, Niu Y. | 07/15/2024 |
| C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel Vasculoprotective Cytokine That Restores High Glucose-Suppressed Endothelial Progenitor Cell Functions by Activating the Endothelial Nitric Oxide Synthase. | C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel Vasculoprotective Cytokine That Restores High Glucose-Suppressed Endothelial Progenitor Cell Functions by Activating the Endothelial Nitric Oxide Synthase.
Hu Q, Qu W, Zhang T, Feng J, Dong X, Nie R, Chen J, Wang X, Peng C, Ke X., Free PMC Article | 02/21/2024 |
| Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress. | Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress.
Wang X, Ma X, Zeng Y, Xu L, Zhang M., Free PMC Article | 11/15/2023 |
| C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation. | C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation.
Haustein R, Trogisch FA, Keles M, Hille S, Fuhrmann M, Weinzierl N, Hemanna S, Thackeray J, Dou Y, Zwadlo C, Froese N, Cordero J, Bengel F, Müller OJ, Bauersachs J, Dobreva G, Heineke J., Free PMC Article | 02/15/2023 |
| Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency. | Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency.
Kim ES, Yoon BH, Lee SM, Choi M, Kim EH, Lee BW, Kim SY, Pack CG, Sung YH, Baek IJ, Jung CH, Kim TB, Jeong JY, Ha CH., Free PMC Article | 07/23/2022 |
| Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina. | Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina.
Inooka D, Omori Y, Ouchi N, Ohashi K, Kawakami Y, Koyanagi Y, Koike C, Terasaki H, Nishiguchi KM, Ueno S., Free PMC Article | 05/28/2022 |
| C1q/tumour necrosis factor-related protein-9 aggravates lipopolysaccharide-induced inflammation via promoting NLRP3 inflammasome activation. | C1q/tumour necrosis factor-related protein-9 aggravates lipopolysaccharide-induced inflammation via promoting NLRP3 inflammasome activation.
Xu D, Zhou X, Chen J, Li N, Ruan S, Zuo A, Lei S, Li L, Guo Y. | 04/2/2022 |
| BCL-6 promotes the methylation of miR-34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury. | BCL-6 promotes the methylation of miR-34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury.
Lin JM, Hsu CH, Chen JC, Kao SH, Lin YC. | 12/18/2021 |
| CTRP9 alleviates foam cells apoptosis by enhancing cholesterol efflux. | CTRP9 alleviates foam cells apoptosis by enhancing cholesterol efflux.
Lei S, Chen J, Song C, Li J, Zuo A, Xu D, Li T, Guo Y. | 08/14/2021 |
| CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway. | CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway.
Zuo A, Zhao X, Li T, Li J, Lei S, Chen J, Xu D, Song C, Liu T, Li C, Guo Y., Free PMC Article | 05/1/2021 |
| CTRP9 induces iNOS expression through JAK2/STAT3 pathway in Raw 264.7 and peritoneal macrophages. | CTRP9 induces iNOS expression through JAK2/STAT3 pathway in Raw 264.7 and peritoneal macrophages.
Chen JY, Lei SY, Li TT, Li J, Zuo AJ, Xu D, Song CX, Guo Y. | 09/12/2020 |
| C1q/Tumor Necrosis Factor-Related Protein-9 Attenuates Diabetic Nephropathy and Kidney Fibrosis in db/db Mice | C1q/Tumor Necrosis Factor-Related Protein-9 Attenuates Diabetic Nephropathy and Kidney Fibrosis in db/db Mice.
Hu H, Li W, Liu M, Xiong J, Li Y, Wei Y, Huang C, Tang Y. | 06/20/2020 |
| autocrine CTRP9 of cardiomyocyte origin protects against myocardial ischemia/reperfusion injury via CRT association. | Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis.
Zhao D, Feng P, Sun Y, Qin Z, Zhang Z, Tan Y, Gao E, Lau WB, Ma X, Yang J, Yu S, Xu X, Yi D, Yi W., Free PMC Article | 11/9/2019 |
| C1q/TNF-related protein-9 attenuates retinal inflammation and protects blood-retinal barrier in db/db mice | C1q/TNF-related protein-9 attenuates retinal inflammation and protects blood-retinal barrier in db/db mice.
Li W, Ma N, Liu MX, Ye BJ, Li YJ, Hu HY, Tang YH. | 09/7/2019 |
| These observations reveal that CTRP9 exerts a protecting role in early atherosclerotic lesions and its anti-atherosclerotic effect is associated with autophagy induction through AMPK/mTOR signaling pathway. | Overexpression of CTRP9 attenuates the development of atherosclerosis in apolipoprotein E-deficient mice.
Huang C, Zhang P, Li T, Li J, Liu T, Zuo A, Chen J, Guo Y. | 04/27/2019 |
| CTRP9 had a significant antisenescence effect in aged mesenchymal stem cells by activating PGC1 alpha/AMPK signaling and decreasing the oxidative response. | CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells.
Li Q, Zhu Z, Wang C, Cai L, Lu J, Wang Y, Xu J, Su Z, Zheng W, Chen X. | 10/13/2018 |
| Authors demonstrate that CTRP9 regulates growth, differentiation, and apoptosis of HaCaT human keratinocytes. We found that CTRP9 augmented expression of transforming growth factor beta 1 (TGFbeta1) by transcription factor activator protein 1 (AP-1) binding activity and phosphorylation of p38 in a dose-dependent manner. | CTRP9 Regulates Growth, Differentiation, and Apoptosis in Human Keratinocytes through TGFβ1-p38-Dependent Pathway.
Jung TW, Park HS, Choi GH, Kim D, Lee T., Free PMC Article | 08/18/2018 |
| CTRP9 is a cardiokine critical in maintaining a healthy microenvironment facilitating stem cell engraftment in infarcted myocardial tissue treated with mesenchymal stem cell transplantation. | C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways.
Yan W, Guo Y, Tao L, Lau WB, Gan L, Yan Z, Guo R, Gao E, Wong GW, Koch WL, Wang Y, Ma XL., Free PMC Article | 12/9/2017 |
| Based on these findings, this study showed that CTRP9 might induce mitochondrial biogenesis and protect high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1alpha signaling pathway. | CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation.
Cheng L, Li B, Chen X, Su J, Wang H, Yu S, Zheng Q. | 05/20/2017 |
| These results suggested that gCTRP9 protected RAW 264.7 macrophages from oxLDL via AMPK activation in an AdipoR1 dependent fashion. | Globular CTRP9 inhibits oxLDL-induced inflammatory response in RAW 264.7 macrophages via AMPK activation.
Zhang P, Huang C, Li J, Li T, Guo H, Liu T, Li N, Zhu Q, Guo Y. | 02/4/2017 |
| Suggest reduced plasma CTRP9 concentration during diabetes plays a causative role in platelet hyper-activity, contributing to platelet-induced cardiovascular damage. | Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals.
Wang W, Lau WB, Wang Y, Ma X, Li R., Free PMC Article | 10/22/2016 |
| Results demonstrate that CTRP9 alleviates hepatic steatosis through relief of endoplasmic reticulum stress via the AMPK-mediated induction of autophagy. | C1q/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of endoplasmic reticulum stress.
Jung TW, Hong HC, Hwang HJ, Yoo HJ, Baik SH, Choi KM. | 10/8/2016 |
| Enhancing cardiac CTRP9 production and/or its proteolytic posttranslational modification are of therapeutic potential, attenuating diabetic cardiac injury. | C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform.
Yuan Y, Lau WB, Su H, Sun Y, Yi W, Du Y, Christopher T, Lopez B, Wang Y, Ma XL., Free PMC Article | 08/8/2015 |
| CTRP9 protects against acute cardiac damage in response to pathological stimuli by suppressing inflammatory reactions through AdipoR1/AMPK-dependent mechanisms. | C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism.
Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, Aprahamian T, Walsh K, Murohara T, Ouchi N., Free PMC Article | 08/8/2015 |