| miR-542-5p targets GREM1 to affect the progression of renal fibrosis. | miR-542-5p targets GREM1 to affect the progression of renal fibrosis.
Pang S, Xie B, Feng B, Xu G, Ye Q, Chen X, Ruan L, Chen H, Pan SL, Xue C, Li W. | 08/26/2024 |
| Expression mapping of GREM1 and functional contribution of its secreting cells in the brain using transgenic mouse models. | Expression mapping of GREM1 and functional contribution of its secreting cells in the brain using transgenic mouse models.
Yao P, Liu X, Miao Q, Li C, Zhou H, Li H, Mao X, Fang X, Li N. | 02/16/2024 |
| Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. | Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis.
Ng JQ, Jafarov TH, Little CB, Wang T, Ali AM, Ma Y, Radford GA, Vrbanac L, Ichinose M, Whittle S, Hunter DJ, Lannagan TRM, Suzuki N, Goyne JM, Kobayashi H, Wang TC, Haynes DR, Menicanin D, Gronthos S, Worthley DL, Woods SL, Mukherjee S., Free PMC Article | 11/3/2023 |
| Gremlin 1 is required for macrophage M2 polarization. | Gremlin 1 is required for macrophage M2 polarization.
Mthunzi L, Rowan SC, Kostyunina DS, Baugh JA, Knaus UG, McLoughlin P. | 08/10/2023 |
| Adipokine gremlin-1 promotes hepatic steatosis via upregulation of ER stress by suppressing autophagy-mediated signaling. | Adipokine gremlin-1 promotes hepatic steatosis via upregulation of ER stress by suppressing autophagy-mediated signaling.
Choi SW, Oh H, Park SY, Cho W, Abd El-Aty AM, Hacimuftuoglu A, Jeong JH, Jung TW. | 05/30/2023 |
| GREM1 is required to maintain cellular heterogeneity in pancreatic cancer. | GREM1 is required to maintain cellular heterogeneity in pancreatic cancer.
Lan L, Evan T, Li H, Hussain A, Ruiz EJ, Zaw Thin M, Ferreira RMM, Ps H, Riising EM, Zen Y, Almagro J, Ng KW, Soro-Barrio P, Nelson J, Koifman G, Carvalho J, Nye EL, He Y, Zhang C, Sadanandam A, Behrens A. | 07/16/2022 |
| Gremlin1 and TGF-beta1 protect kidney tubular epithelial cells from ischemia-reperfusion injury through different pathways. | Gremlin1 and TGF-β1 protect kidney tubular epithelial cells from ischemia-reperfusion injury through different pathways.
Gao X, Han L, Yao X, Ma L. | 05/14/2022 |
| Protective role of Gremlin-1 in myocardial function. | Protective role of Gremlin-1 in myocardial function.
Müller II, Schneider M, Müller KAL, Lunov O, Borst O, Simmet T, Gawaz M. | 12/25/2021 |
| Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration. | Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration.
Koppens MAJ, Davis H, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L, Oxford IBD Cohort Investigators, Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ., Free PMC Article | 10/30/2021 |
| Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity. | Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity.
Malkmus J, Ramos Martins L, Jhanwar S, Kircher B, Palacio V, Sheth R, Leal F, Duchesne A, Lopez-Rios J, Peterson KA, Reinhardt R, Onimaru K, Cohn MJ, Zuniga A, Zeller R., Free PMC Article | 10/16/2021 |
| The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses. | The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.
Ichinose M, Suzuki N, Wang T, Kobayashi H, Vrbanac L, Ng JQ, Wright JA, Lannagan TRM, Gieniec KA, Lewis M, Ando R, Enomoto A, Koblar S, Thomas P, Worthley DL, Woods SL., Free PMC Article | 08/28/2021 |
| Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure. | Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure.
Rowan SC, Jahns H, Mthunzi L, Piouceau L, Cornwell J, Doody R, Frohlich S, Callanan JJ, McLoughlin P., Free PMC Article | 09/26/2020 |
| Down-regulation of Gremlin1 inhibits inflammatory response and vascular permeability in chronic idiopathic urticaria through suppression of TGF-beta signaling pathway. | Down-regulation of Gremlin1 inhibits inflammatory response and vascular permeability in chronic idiopathic urticaria through suppression of TGF-β signaling pathway.
Qu S, Liu Z, Wang B. | 08/13/2020 |
| GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients | GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients.
Neckmann U, Wolowczyk C, Hall M, Almaas E, Ren J, Zhao S, Johannessen B, Skotheim RI, Bjørkøy G, Ten Dijke P, Holien T., Free PMC Article | 07/18/2020 |
| remlin can aggravate podocyte lesions through the TGF-beta signaling pathway. | Gremlin Regulates Podocyte Apoptosis via Transforming Growth Factor-β (TGF-β) Pathway in Diabetic Nephropathy.
Wang XB, Zhu H, Song W, Su JH., Free PMC Article | 08/4/2018 |
| We conclude that gremlin promotes RPE cell proliferation, migration and VEGF production possibly via activating VEGFR2-Akt-mTORC2 signaling. Gremlin could be a novel therapeutic target of ROP or other retinal vasoproliferation diseases. | Gremlin promotes retinal pigmentation epithelial (RPE) cell proliferation, migration and VEGF production via activating VEGFR2-Akt-mTORC2 signaling.
Liu Y, Chen Z, Cheng H, Chen J, Qian J., Free PMC Article | 03/10/2018 |
| Wild-type gremlin is able to bind broadly across the various regions of kidney in an heparin sulfate-dependent manner, with particularly intense binding to tubular structures in the renal cortex. In a model of chronic kidney disease, fibrotic changes in the kidney result in a loss of gremlin binding sites. Gremlin mutants with reduced affinity for heparin showed negligible binding under the same conditions. | The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: Such binding is not essential for BMP antagonism.
Tatsinkam AJ, Rune N, Smith J, Norman JT, Mulloy B, Rider CC. | 11/4/2017 |
| involved in regulation of bone morphogenetic protein activities in cartilage tissues in the adult skeleton | Expression of Noggin and Gremlin1 and its implications in fine-tuning BMP activities in mouse cartilage tissues.
Yu X, Kawakami H, Tahara N, Olmer M, Hayashi S, Akiyama R, Bagchi A, Lotz M, Kawakami Y., Free PMC Article | 09/23/2017 |
| Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA, and COL1a1 expression in a liver fibrosis disease model. | Gremlin1 Accelerates Hepatic Stellate Cell Activation Through Upregulation of TGF-Beta Expression.
Zhang YQ, Wan LY, He XM, Ni YR, Wang C, Liu CB, Wu JF. | 09/23/2017 |
| Grem1 expression in the tubular epithelial compartment plays a significant role in the fibrotic response to renal injury in vivo. | Gremlin1 plays a key role in kidney development and renal fibrosis.
Church RH, Ali I, Tate M, Lavin D, Krishnakumar A, Kok HM, Hombrebueno JR, Dunne PD, Bingham V, Goldschmeding R, Martin F, Brazil DP., Free PMC Article | 08/12/2017 |
| Gremlin-1 protein expression was detected specifically in the lung after birth and did not result in any signs of respiratory insufficiency. CXCL10 chemokine levels correlate negatively with gremlin-1 levels in mouse and human lung. | Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment - A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine.
Koli K, Sutinen E, Rönty M, Rantakari P, Fortino V, Pulkkinen V, Greco D, Sipilä P, Myllärniemi M., Free PMC Article | 07/29/2017 |
| Data show that parathyroid hormone-related protein (PTHrP) regulates gremlin levels in pancreatic acinar and stellate cells. | Parathyroid Hormone-Related Protein Interacts With the Transforming Growth Factor-β/Bone Morphogenetic Protein-2/Gremlin Signaling Pathway to Regulate Proinflammatory and Profibrotic Mediators in Pancreatic Acinar and Stellate Cells.
Bhatia V, Cao Y, Ko TC, Falzon M., Free PMC Article | 01/14/2017 |
| Gremlin is a key pro-fibrogenic factor in chronic pancreatitis | Gremlin is a key pro-fibrogenic factor in chronic pancreatitis.
Staloch D, Gao X, Liu K, Xu M, Feng X, Aronson JF, Falzon M, Greeley GH, Rastellini C, Chao C, Hellmich MR, Cao Y, Ko TC., Free PMC Article | 07/30/2016 |
| Gremlin/VEGFR2 axis participates in renal inflammation and could be a novel target for kidney disease. | Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
Lavoz C, Alique M, Rodrigues-Diez R, Pato J, Keri G, Mezzano S, Egido J, Ruiz-Ortega M. | 10/10/2015 |
| GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients. | Gremlin promotes peritoneal membrane injury in an experimental mouse model and is associated with increased solute transport in peritoneal dialysis patients.
Siddique I, Curran SP, Ghayur A, Liu L, Shi W, Hoff CM, Gangji AS, Brimble KS, Margetts PJ., Free PMC Article | 07/25/2015 |