| SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia: A long-term study. | SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia: A long-term study.
Xu N, Li LS, Li H, Zhang LH, Zhang N, Wang PJ, Cheng YX, Xiang JY, Linghu EQ, Chai NL., Free PMC Article | 07/10/2023 |
| MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells. | MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells.
Cui Y, Liu R, Hong Y, Wang Y, Zhu Y, Wen T, Lu J, Mao S, Wang X, Pan J, Luo Y., Free PMC Article | 11/12/2022 |
| Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome. | Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome.
Xu L, Xiong F, Bai Y, Xiao J, Zhang Y, Chen J, Li Q., Free PMC Article | 03/5/2022 |
| Risk of Nasopharyngeal Carcinoma Associated with Single Nucleotide Polymorphisms in the MicroRNA Binding Site of SGK3. | Risk of Nasopharyngeal Carcinoma Associated with Single Nucleotide Polymorphisms in the MicroRNA Binding Site of SGK3.
Zheng H, Wu L, Wang X, Chen Q. | 06/26/2021 |
| Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. | Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival.
Nalairndran G, Hassan Abdul Razack A, Mai CW, Fei-Lei Chung F, Chan KK, Hii LW, Lim WM, Chung I, Leong CO., Free PMC Article | 05/8/2021 |
| MiR-377-3p inhibits cell metastasis and epithelial-mesenchymal transition in cervical carcinoma through targeting SGK3. | MiR-377-3p inhibits cell metastasis and epithelial-mesenchymal transition in cervical carcinoma through targeting SGK3.
Zhang XY, Dong XM, Wang FP. | 04/24/2021 |
| Mutation of SGK3, a Novel Regulator of Renal Phosphate Transport, Causes Autosomal Dominant Hypophosphatemic Rickets. | Mutation of SGK3, a Novel Regulator of Renal Phosphate Transport, Causes Autosomal Dominant Hypophosphatemic Rickets.
Cebeci AN, Zou M, BinEssa HA, Alzahrani AS, Al-Rijjal RA, Al-Enezi AF, Al-Mohanna FA, Cavalier E, Meyer BF, Shi Y. | 02/6/2021 |
| In patients with polycystic ovary syndrome, miR-335-5p is involved in granulosa cells proliferation by reducing SGK3 expression. | MiRNA-335-5p negatively regulates granulosa cell proliferation via SGK3 in PCOS.
Yao L, Li M, Hu J, Wang W, Gao M. | 04/11/2020 |
| Study data from human hepatocellular carcinoma (HCC) liver samples, human HCC cells, and Sgk3 knockout mice model suggest that SGK3 plays a role in transducing helical domain mutant PIK3CA signaling during liver tumor development. | Functional role of SGK3 in PI3K/Pten driven liver tumor development.
Cao H, Xu Z, Wang J, Cigliano A, Pilo MG, Ribback S, Zhang S, Qiao Y, Che L, Pascale RM, Calvisi DF, Chen X., Free PMC Article | 08/17/2019 |
| overexpression of INPP4B promotes NPM1-mutated leukemia cell proliferation through SGK3 activation. High levels of INPP4B are at least partially induced by the NPM1 mutant via ERK/Ets-1 signaling. | INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.
Jin H, Yang L, Wang L, Yang Z, Zhan Q, Tao Y, Zou Q, Tang Y, Xian J, Zhang S, Jing Y, Zhang L., Free PMC Article | 05/11/2019 |
| Mechanism of activation of SGK3 by IGF1 via the class 1 and class 3 phosphatidylinositol 3-kinases has been described. | Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.
Malik N, Macartney T, Hornberger A, Anderson KE, Tovell H, Prescott AR, Alessi DR., Free PMC Article | 09/8/2018 |
| Hence, we concluded that miR1443p, which is frequently downregulated in hepatocellular carcinoma (HCC) can inhibit proliferation, migration and repress angiogenesis by regulating SGK3 activation with PI3K independent signal pathway, and acts as a prognostic factor for HCC patients. | MicroRNA-144-3p suppresses tumor growth and angiogenesis by targeting SGK3 in hepatocellular carcinoma.
Wu M, Huang C, Huang X, Liang R, Feng Y, Luo X., Free PMC Article | 05/12/2018 |
| SGK3 a kinase transcriptionally regulated by estrogen receptor alpha (ERalpha) in breast cancer, sustains ERalpha signaling and drives the acquired aromatase inhibitors resistance by protecting against endoplasmic reticulum (EnR) stress-induced ERalpha downregulation and cell death through preserving SERCA2b function. | SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis.
Wang Y, Zhou D, Phung S, Warden C, Rashid R, Chan N, Chen S., Free PMC Article | 04/14/2018 |
| High SGK3 expression is associated with epithelial-mesenchymal transition in hepatocellular carcinoma. | MiR-155 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells through the activation of PI3K/SGK3/β-catenin signaling pathways.
Kong X, Liu F, Gao J., Free PMC Article | 03/17/2018 |
| These findings highlight the importance of the hVps34-SGK3 pathway in counteracting inhibition of PI3K/Akt signalling. | The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.
Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR., Free PMC Article | 07/1/2017 |
| Data show that activation of serum- and glucocorticoid-regulated kinase 3 (SGK3) plays an important role in inositol polyphosphate 4-phosphatase type II (INPP4B)-mediated melanoma cell proliferation. | INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.
Chi MN, Guo ST, Wilmott JS, Guo XY, Yan XG, Wang CY, Liu XY, Jin L, Tseng HY, Liu T, Croft A, Hondermarck H, Scolyer RA, Jiang CC, Zhang XD., Free PMC Article | 09/24/2016 |
| It is unlikely that SGK3 plays a significant role for oncogenic signalling in multiple myeloma. | Loss of serum and glucocorticoid-regulated kinase 3 (SGK3) does not affect proliferation and survival of multiple myeloma cell lines.
Hausmann S, Brandt E, Köchel C, Einsele H, Bargou RC, Seggewiss-Bernhardt R, Stühmer T., Free PMC Article | 04/16/2016 |
| SGK3 is a key mediator of PDK1 activity in melanoma. | PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets.
Scortegagna M, Lau E, Zhang T, Feng Y, Sereduk C, Yin H, De SK, Meeth K, Platt JT, Langdon CG, Halaban R, Pellecchia M, Davies MA, Brown K, Stern DF, Bosenberg M, Ronai ZA., Free PMC Article | 01/30/2016 |
| VPS34-IN1 will provide a useful tool to decipher the kinase-dependent functions of Vps34, with acute changes in SGK3 phosphorylation and subcellular localization being new biomarkers of Vps34 activity | Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection.
Bilanges B, Vanhaesebroeck B. | 03/21/2015 |
| Breast cancers harboring oncogenic PIK3CA activate SGK3 signaling while suppressing Akt, indicative of oncogenic functions for both INPP4B and SGK3 in these tumors. | SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.
Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A., Free PMC Article | 02/28/2015 |
| SGK3 is an androgen receptor (AR) target and induces cell proliferation through the AR-SGK3-p70S6K-cyclin D1 pathway in prostate cancer cells. | SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1.
Wang Y, Zhou D, Chen S., Free PMC Article | 01/24/2015 |
| SGK3 is a novel regulator of K(ir)2.1. | Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3.
Munoz C, Pakladok T, Almilaji A, Elvira B, Decher N, Shumilina E, Lang F. | 10/18/2014 |
| SGK3 stability and kinase activation are regulated by the Hsp90-Cdc37 chaperone complex. | Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex.
Wang Y, Xu W, Zhou D, Neckers L, Chen S., Free PMC Article | 04/26/2014 |
| SGK1,3 enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling. | The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.
Lamothe SM, Zhang S., Free PMC Article | 08/10/2013 |
| A positive correlation between SGK3 expression and breast tumor prognosis. | SGK3 is associated with estrogen receptor expression in breast cancer.
Xu J, Wan M, He Q, Bassett RL Jr, Fu X, Chen AC, Shi F, Creighton CJ, Schiff R, Huo L, Liu D., Free PMC Article | 11/24/2012 |