| Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients. | Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients.
Zarafshani M, Mahmoodzadeh H, Soleimani V, Moosavi MA, Rahmati M., Free PMC Article | 03/12/2024 |
| S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. | S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy.
Huang X, Yao J, Liu L, Chen J, Mei L, Huangfu J, Luo D, Wang X, Lin C, Chen X, Yang Y, Ouyang S, Wei F, Wang Z, Zhang S, Xiang T, Neculai D, Sun Q, Kong E, Tate EW, Yang A., Free PMC Article | 11/1/2023 |
| Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis. | Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Feng R, Liu J, Yang Z, Yao T, Ye P, Li X, Zhang J, Jiang H. | 09/6/2023 |
| The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. | The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway.
Liang X, Yao J, Cui D, Zheng W, Liu Y, Lou G, Ye B, Shui L, Sun Y, Zhao Y, Zheng M., Free PMC Article | 06/13/2023 |
| Autophagy Receptor p62 Regulates SARS-CoV-2-Induced Inflammation in COVID-19. | Autophagy Receptor p62 Regulates SARS-CoV-2-Induced Inflammation in COVID-19.
Paunovic V, Vucicevic L, Misirkic Marjanovic M, Perovic V, Ristic B, Bosnjak M, Mandic M, Stevanovic D, Harhaji-Trajkovic L, Lalosevic J, Nikolic M, Bonaci-Nikolic B, Trajkovic V., Free PMC Article | 05/24/2023 |
| Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis. | Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis.
Akbar H, Cao J, Wang D, Yuan X, Zhang M, Muthusamy S, Song X, Liu X, Aikhionbare F, Yao X, Gao X, Liu X., Free PMC Article | 02/23/2023 |
| Mislocalization of Nup62 Contributes to TDP-43 Proteinopathy in ALS/FTLD. | Mislocalization of Nup62 Contributes to TDP-43 Proteinopathy in ALS/FTLD.
Nag N, Tripathi T. | 10/1/2022 |
| Alterations of the 70 kDa heat shock protein (HSP70) and sequestosome-1 (p62) in women with breast cancer. | Alterations of the 70 kDa heat shock protein (HSP70) and sequestosome-1 (p62) in women with breast cancer.
Orfanelli T, Giannopoulos S, Zografos E, Athanasiou A, Bongiovanni AM, Doulaveris G, Moo TA, LaPolla D, Bakoyiannis CN, Theodoropoulos GE, Zografos GC, Andreopoulou E, Witkin SS., Free PMC Article | 02/5/2022 |
| NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cells. | NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cells.
Makiyama K, Hazawa M, Kobayashi A, Lim K, Voon DC, Wong RW., Free PMC Article | 01/8/2022 |
| p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin-proteasome system. | p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin-proteasome system.
Fu A, Cohen-Kaplan V, Avni N, Livneh I, Ciechanover A., Free PMC Article | 12/18/2021 |
| DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1. | DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Zheng Y, Xu B, Zhao Y, Yang S, Wang S, Ma L, Dong L. | 12/4/2021 |
| NUP62 is required for the maintenance of the spindle assembly checkpoint and chromosomal stability. | NUP62 is required for the maintenance of the spindle assembly checkpoint and chromosomal stability.
Chien ML, Lai JH, Lin TF, Yang WS, Juang YL. | 08/21/2021 |
| The low expression of NUP62CL indicates good prognosis and high level of immune infiltration in lung adenocarcinoma. | The low expression of NUP62CL indicates good prognosis and high level of immune infiltration in lung adenocarcinoma.
Ren S, Wang W, Zhang C, Sun Y, Sun M, Wang Y, Zhang X, Lu B, Yao L., Free PMC Article | 07/24/2021 |
| Nuclear Pore Complex 62 Promotes Metastasis of Gastric Cancer by Regulating Wnt/beta-Catenin and TGF-beta Signaling Pathways. | Nuclear Pore Complex 62 Promotes Metastasis of Gastric Cancer by Regulating Wnt/β-Catenin and TGF-β Signaling Pathways.
Wang H, Lin Y, Jin J, Shen H, Dai C. | 04/13/2021 |
| Using a rapid and efficient protocol to differentiate mouse embryonic stem cells (ESC) to SpMNs and CrMNs, we now report that ESC-derived CrMNs accumulate less human (h)SOD1 and insoluble p62 than SpMNs over time | Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons.
An D, Fujiki R, Iannitelli DE, Smerdon JW, Maity S, Rose MF, Gelber A, Wanaselja EK, Yagudayeva I, Lee JY, Vogel C, Wichterle H, Engle EC, Mazzoni EO., Free PMC Article | 02/29/2020 |
| XIAP enhanced cancer cell proliferation, viability, and colony formation in vitro via suppression of p62. In addition, we demonstrated that XIAP-enhanced tumor growth is dependent on depletion of p62 in vivo. Herein, we have therefore delineated a novel mechanism by which XIAP contributes to development and progression of breast and colon carcinoma | XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation.
Huang X, Wang XN, Yuan XD, Wu WY, Lobie PE, Wu Z. | 03/2/2019 |
| ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. | ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.
Hazawa M, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Hartono, Nakada M, Meguro-Horike M, Horike SI, Koeffler HP, Wong RW., Free PMC Article | 01/5/2019 |
| it was revealed that a fraction of Nup62 was associated with mitotic spindle microtubule instead of spindle matrix, and the localization of Nup62 in the mitotic spindle depended on its three coiled-coil domains rather than Crm1, although Nup62 strongly interacted with Crm1 during mitosis. Moreover, depletion of Nup62 by small interference of RNA seriously induced the defects of chromosome alignment and spindle assembly | Nup62, associated with spindle microtubule rather than spindle matrix, is involved in chromosome alignment and spindle assembly during mitosis.
Wu Z, Jin Z, Zhang X, Shen N, Wang J, Zhao Y, Mei L. | 03/4/2017 |
| Knockdown of Nup62 (and CaMKK2) reduced androgen receptor transcriptional activity in castrate resistant prostate cancer cells. | Nucleoporin 62 and Ca(2+)/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells.
Karacosta LG, Kuroski LA, Hofmann WA, Azabdaftari G, Mastri M, Gocher AM, Dai S, Hoste AJ, Edelman AM. | 05/21/2016 |
| The data presented here suggest that BGLF4 interferes with the normal functions of Nup62 and Nup153 and preferentially helps the nuclear import of viral proteins for viral DNA replication and assembly. | BGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteins.
Chang CW, Lee CP, Su MT, Tsai CH, Chen MR., Free PMC Article | 04/11/2015 |
| These data reveal an emergent Kap-centric barrier mechanism that may underlie mechanistic and kinetic control in the nuclear pore complex. | Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins.
Kapinos LE, Schoch RL, Wagner RS, Schleicher KD, Lim RY., Free PMC Article | 12/6/2014 |
| Loss of presenilin (PS)1 function propagates tau accumulation through impairment of cargo-receptor protein p62-dependent tau degradation. | Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation.
Tung YT, Wang BJ, Hsu WM, Hu MK, Her GM, Huang WP, Liao YF. | 11/8/2014 |
| Nup62 depletion leads to the appearance of multinucleated cells and induces the formation of multipolar centrosomes, centriole synthesis defects, dramatic spindle orientation defects, and centrosome component rearrangements that impair cell bi-polarity. | Nucleoporin Nup62 maintains centrosome homeostasis.
Hashizume C, Moyori A, Kobayashi A, Yamakoshi N, Endo A, Wong RW., Free PMC Article | 09/13/2014 |
| A hydrophobic patch 65LRLFV69 within the zinc-binding domain is essential for the nuclear import and localization of HPV8 E7 via hydrophobic interactions with Nup62 and Nup153. | Nuclear import of cutaneous beta genus HPV8 E7 oncoprotein is mediated by hydrophobic interactions between its zinc-binding domain and FG nucleoporins.
Onder Z, Moroianu J., Free PMC Article | 04/12/2014 |
| Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase. | Quantitative regulation of nuclear pore complex proteins by O-GlcNAcylation.
Mizuguchi-Hata C, Ogawa Y, Oka M, Yoneda Y. | 03/1/2014 |