| N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation. | N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
Li X, Tang X, Xiang Y, Zhao Z, Li Y, Ding Q, Zhang L, Xu J, Zhao L, Chen Y. | 09/17/2024 |
| The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway. | The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway.
Huang Y, Wang YF, Ruan XZ, Lau CW, Wang L, Huang Y., Free PMC Article | 01/30/2024 |
| SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice. | SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Zheng G, Su Y, Wei L, Yao Y, Wang Y, Luo X, Wang X, Ruan XZ, Li D, Chen Y., Free PMC Article | 04/12/2023 |
| SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization. | SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization.
Lee JH, Lee SH, Lee EH, Cho JY, Song DK, Lee YJ, Kwon TK, Oh BC, Cho KW, Osborne TF, Jeon TI, Im SS., Free PMC Article | 03/1/2023 |
| Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-kappaB Signaling Pathway. | Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.
Huang X, Yao Y, Hou X, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D, Chen Y., Free PMC Article | 06/25/2022 |
| Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. | Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kishikawa T, Kinoshita H, Nakatsuka T, Sato M, Kudo Y, Hoshida Y, Umemura A, Eguchi A, Ikenoue T, Hirata Y, Uesugi M, Tateishi R, Tateishi K, Fujishiro M, Koike K, Nakagawa H., Free PMC Article | 06/11/2022 |
| DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice. | DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice.
Seidu T, McWhorter P, Myer J, Alamgir R, Eregha N, Bogle D, Lofton T, Ecelbarger C, Andrisse S., Free PMC Article | 08/21/2021 |
| Autophagy in VSMCs was increased in SM22alpha-Cre:SCAP(flox/+):ApoE(-/-) mice. | SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE(-/-) mice.
Li D, Chen A, Lan T, Zou Y, Zhao L, Yang P, Qu H, Wei L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ. | 11/16/2019 |
| Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. | Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA., Free PMC Article | 08/4/2018 |
| Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2. | Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.
Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P., Free PMC Article | 06/9/2018 |
| Reexpression of SCAP in SCAP-deficient cells restored SREBP2 protein expression and partially restored steroidogenic responses, confirming the requirement of SCAP-SREBP2 in steroidogenesis. | SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.
Shimizu-Albergine M, Van Yserloo B, Golkowski MG, Ong SE, Beavo JA, Bornfeldt KE., Free PMC Article | 01/27/2018 |
| This study found that deletion of SREBP activity in astrocytes resulted in impaired presynaptic terminal function and synaptic plasticity, possibly via a decrease in the presynaptic protein SNAP-25 levels and the number of synaptic vesicles. | Astrocyte lipid metabolism is critical for synapse development and function in vivo.
van Deijk AF, Camargo N, Timmerman J, Heistek T, Brouwers JF, Mogavero F, Mansvelder HD, Smit AB, Verheijen MH. | 01/13/2018 |
| Data, including data from studies using transgenic mice, suggest that oligodendroglial myelination requires astrocyte-derived lipids; oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential factor in lipid biosynthesis along with SREBP2, results in significantly retarded CNS myelination. | Oligodendroglial myelination requires astrocyte-derived lipids.
Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG., Free PMC Article | 09/9/2017 |
| The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate. | Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
Hashimoto M, Kobayashi K, Yamazaki M, Kazuki Y, Takehara S, Oshimura M, Chiba K. | 06/24/2017 |
| characterizes SCAP as an essential adaptor in the STING signaling pathway, uncovering a critical missing link in DNAs-triggered host antiviral responses | ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs.
Chen W, Li S, Yu H, Liu X, Huang L, Wang Q, Liu H, Cui Y, Tang Y, Zhang P, Wang C., Free PMC Article | 07/30/2016 |
| intestine requires Scap to sustain tissue integrity by maintaining the high levels of lipid synthesis necessary for proliferation of intestinal crypts | Scap is required for sterol synthesis and crypt growth in intestinal mucosa.
McFarlane MR, Cantoria MJ, Linden AG, January BA, Liang G, Engelking LJ., Free PMC Article | 04/30/2016 |
| Reduction of SCAP and the consequent suppression of cholesterol synthesis in the brain may play an important role in the increased rates of cognitive decline and Alzheimer disease observed in diabetic states. | Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
Suzuki R, Ferris HA, Chee MJ, Maratos-Flier E, Kahn CR., Free PMC Article | 10/19/2013 |
| the SCAP/SREBP signaling axis has a role in protecting cancer cells from lipotoxicity | An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.
Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ., Free PMC Article | 06/29/2013 |
| Steatosis in insulin-resistant ob/ob mice was abolished by deletion of Scap, an escort protein necessary for generating nuclear isoforms of all three SREBPs. | The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.
Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD., Free PMC Article | 06/16/2012 |
| inhibited the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig | Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques.
Tang JJ, Li JG, Qi W, Qiu WW, Li PS, Li BL, Song BL. | 02/26/2011 |
| SCAP-mediated regulation of glial lipogenesis is key to the proper synthesis of myelin membrane | SCAP is required for timely and proper myelin membrane synthesis.
Verheijen MH, Camargo N, Verdier V, Nadra K, de Preux Charles AS, Médard JJ, Luoma A, Crowther M, Inouye H, Shimano H, Chen S, Brouwers JF, Helms JB, Feltri ML, Wrabetz L, Kirschner D, Chrast R, Smit AB., Free PMC Article | 02/15/2010 |
| Deletion of the SCAP/SREBP pathway in respiratory epithelial cells altered lung lipid homeostasis and induced compensatory lipid accumulation and synthesis in lung lipofibroblasts. | Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.
Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA., Free PMC Article | 01/21/2010 |
| In L-Scap- mice, intermittent hypoxia did not have any effect on serum & liver lipids, & expression of lipid metabolic genes was not altered, suggesting that Scap mediates the effect of intermittent hypoxia on dyslipidemia. | Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
Li J, Nanayakkara A, Jun J, Savransky V, Polotsky VY. | 01/21/2010 |
| 1,003 genes showed statistically significant increased expression in livers of transgenic SREBP-1a mice, 505 increased in livers of transgenic SREBP-2 mice, and 343 showed decreased expression in Scap-/- livers. | Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL., Free PMC Article | 01/21/2010 |
| liver SCAP has a role in fatty acid synthesis in adipose tissue of mice | Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS. | 01/21/2010 |