| RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing. | RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.
Maurin M, Ranjouri M, Megino-Luque C, Newberg JY, Du D, Martin K, Miner RE 3rd, Prater MS, Wee DKB, Centeno B, Pruett-Miller SM, Stewart P, Fleming JB, Yu X, Bravo-Cordero JJ, Guccione E, Black MA, Mann KM., Free PMC Article | 12/29/2023 |
| FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing. | FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.
Li S, Chen Y, Xie Y, Zhan H, Zeng Y, Zeng K, Wang L, Zhan Z, Li C, Zhao L, Chen X, Tan Y, Wang Z, Bu J, Song Y, Deng F, Zhou A., Free PMC Article | 11/30/2023 |
| RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer. | RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer.
Xie S, Li Z, Zhong Y, Fang Q, Ma A, Wang Y, Zeng L, Lin T, Xie D. | 08/2/2023 |
| RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. | RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R., Free PMC Article | 05/17/2023 |
| The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer. | The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.
Zheng Y, Niu X, Xue W, Li L, Geng Q, Fan Z, Zhao J., Free PMC Article | 12/10/2022 |
| The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation. | The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
Vecellio Reane D, Cerqua C, Sacconi S, Salviati L, Trevisson E, Raffaello A., Free PMC Article | 07/16/2022 |
| Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies. | Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
Cooper AM, Nutter CA, Kuyumcu-Martinez MN, Wright CW., Free PMC Article | 05/28/2022 |
| RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis. | RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.
Luo CL, Xu XC, Liu CJ, He S, Chen JR, Feng YC, Liu SQ, Peng W, Zhou YQ, Liu YX, Wei PP, Li B, Mai HQ, Xia XJ, Bei JX., Free PMC Article | 12/25/2021 |
| Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer. | Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer.
Mochizuki Y, Funayama R, Shirota M, Kikukawa Y, Ohira M, Karasawa H, Kobayashi M, Ohnuma S, Unno M, Nakayama K. | 11/27/2021 |
| SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. | SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
Kim JH, Jeong K, Li J, Murphy JM, Vukadin L, Stone JK, Richard A, Tran J, Gillespie GY, Flemington EK, Sobol RW, Lim SS, Ahn EE., Free PMC Article | 10/16/2021 |
| RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners. | RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners.
Zhou D, Couture S, Scott MS, Abou Elela S., Free PMC Article | 10/9/2021 |
| Trophoblast lineage specific expression of the alternative splicing factor RBFOX2 suggests a role in placental development. | Trophoblast lineage specific expression of the alternative splicing factor RBFOX2 suggests a role in placental development.
Goldman-Wohl D, Greenfield C, Eisenberg-Loebl I, Denichenko P, Jbara A, Karni R, Ariel I, Yagel S. | 08/14/2021 |
| ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion. | ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion.
Saulnier O, Guedri-Idjouadiene K, Aynaud MM, Chakraborty A, Bruyr J, Pineau J, O'Grady T, Mirabeau O, Grossetête S, Galvan B, Claes M, Al Oula Hassoun Z, Sadacca B, Laud K, Zaïdi S, Surdez D, Baulande S, Rambout X, Tirode F, Dutertre M, Delattre O, Dequiedt F., Free PMC Article | 07/10/2021 |
| Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity. | Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity.
Begg BE, Jens M, Wang PY, Minor CM, Burge CB., Free PMC Article | 12/19/2020 |
| Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. | Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy.
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A., Free PMC Article | 10/24/2020 |
| Data show that exon 10, responsible for nuclear localization, of RBFOX2. was absent in calcific tendons. | Alternative splicing induces cytoplasmic localization of RBFOX2 protein in calcific tendinopathy.
Cho N, Kim JO, Lee S, Choi S, Kim J, Ko MS, Park SJ, Ji JH, Kim KK. | 02/29/2020 |
| Results provide evidence that RBFOX2 expression in epithelial ovarian cancer is regulated by MALAT1 which its alternative splicing. | The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing.
Gordon MA, Babbs B, Cochrane DR, Bitler BG, Richer JK. | 06/22/2019 |
| The authors report that a subset of cell cycle-related genes including retinoblastoma 1 is the target of Rbfox2 in cytoplasmic stress granules, and Rbfox2 regulates the retinoblastoma 1 mRNA and protein expression levels during and following stress exposure. | Stress Granules Contain Rbfox2 with Cell Cycle-related mRNAs.
Park C, Choi S, Kim YE, Lee S, Park SH, Adelstein RS, Kawamoto S, Kim KK., Free PMC Article | 06/15/2019 |
| Rbfox2 nonsense mutation is associated with hypoplastic left heart syndrome. | Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts.
Verma SK, Deshmukh V, Nutter CA, Jaworski E, Jin W, Wadhwa L, Abata J, Ricci M, Lincoln J, Martin JF, Yeo GW, Kuyumcu-Martinez MN., Free PMC Article | 06/30/2018 |
| Data show that while RBFOX1 and RBFOX2 do not mediate neuron-specific processing of UBE3A-ATS, these proteins play important roles in developing neurons and are not completely functionally redundant. | RBFOX1 and RBFOX2 are dispensable in iPSCs and iPSC-derived neurons and do not contribute to neural-specific paternal UBE3A silencing.
Chen PF, Hsiao JS, Sirois CL, Chamberlain SJ., Free PMC Article | 02/24/2018 |
| Results showed that the expression patterns of these genes were indicative of the onset of EMT in in-vitro models, but not in tissue samples. However, the ratio between ESRP1 or ESRP2 and RBFOX2 significantly decreased during EMT and positively correlated with the EMT-specific phenotype in cell models. Low ESRP1/RBFOX2 ratio value was associated with a higher risk of metastasis in early breast cancer patients. | Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer.
Fici P, Gallerani G, Morel AP, Mercatali L, Ibrahim T, Scarpi E, Amadori D, Puisieux A, Rigaud M, Fabbri F., Free PMC Article | 02/24/2018 |
| Rbfox2 modulates the functions of vascular CaV1.2 calcium channel by dynamically regulating the expressions of alternative exons 9* and 33, which in turn affects the vascular myogenic tone. | Aberrant Splicing Induced by Dysregulated Rbfox2 Produces Enhanced Function of Ca(V)1.2 Calcium Channel and Vascular Myogenic Tone in Hypertension.
Zhou Y, Fan J, Zhu H, Ji L, Fan W, Kapoor I, Wang Y, Wang Y, Zhu G, Wang J. | 11/25/2017 |
| RBFOX2 dysregulation by dominant-negative RBFOX2 is an early pathogenic event in diabetic hearts. | Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.
Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN., Free PMC Article | 09/23/2017 |
| RBFox2 interactis with chromatin in a nascent RNA-dependent manner. RBFox2 inactivation eradicates PRC2 targeting on the majority of bivalent gene promoters and leads to transcriptional de-repression. | RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes.
Wei C, Xiao R, Chen L, Cui H, Zhou Y, Xue Y, Hu J, Zhou B, Tsutsui T, Qiu J, Li H, Tang L, Fu XD., Free PMC Article | 08/26/2017 |
| Some of the widespread cellular functions of Rbfox2 protein are attributable to regulation of miRNA biogenesis, and might include the mis-regulation of miR-20b and miR-107 in cancer and neurodegeneration. | Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.
Chen Y, Zubovic L, Yang F, Godin K, Pavelitz T, Castellanos J, Macchi P, Varani G., Free PMC Article | 07/8/2017 |