| MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies. | MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.
Champion A, Rowland A, Yee L, van den Boomen D, Reeves M, Lehner P, Sinclair J, Poole E., Free PMC Article | 01/31/2024 |
| MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity. | MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity.
Ma XH, Yao YX, Wang XZ, Zhou YP, Huang SN, Li D, Mei MJ, Wu JP, Pan YT, Cheng S, Jiang X, Sun JY, Zeng WB, Gong S, Cheng H, Luo MH, Yang B. | 09/24/2022 |
| En garde! The duel functions of MORC3. | En garde! The duel functions of MORC3.
Fox LE, Lenschow DJ. | 02/19/2022 |
| Self-guarding of MORC3 enables virulence factor-triggered immunity. | Self-guarding of MORC3 enables virulence factor-triggered immunity.
Gaidt MM, Morrow A, Fairgrieve MR, Karr JP, Yosef N, Vance RE., Free PMC Article | 02/5/2022 |
| Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation. | Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.
Groh S, Milton AV, Marinelli LK, Sickinger CV, Russo A, Bollig H, de Almeida GP, Schmidt A, Forné I, Imhof A, Schotta G., Free PMC Article | 11/13/2021 |
| Data show that MORC family CW-type zinc finger 3 (MORC3) ATPase is a new target of NS1 protein, influenza A virus (NS1) from H3N2-subtype influenza virus. | MORC3 Is a Target of the Influenza A Viral Protein NS1.
Zhang Y, Ahn J, Green KJ, Vann KR, Black J, Brooke CB, Kutateladze TG., Free PMC Article | 05/2/2020 |
| Mechanism for autoinhibition and activation | Mechanism for autoinhibition and activation of the MORC3 ATPase.
Zhang Y, Klein BJ, Cox KL, Bertulat B, Tencer AH, Holden MR, Wright GM, Black J, Cardoso MC, Poirier MG, Kutateladze TG., Free PMC Article | 06/1/2019 |
| our studies provide a molecular framework detailing MORC3 functions and suggest that its modulation may contribute to human disease. | Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG., Free PMC Article | 02/10/2018 |
| Dermatomyositis patients with anti-NXP-2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease. | Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.
Rogers A, Chung L, Li S, Casciola-Rosen L, Fiorentino DF., Free PMC Article | 12/16/2017 |
| MORC3 has antiviral activity during herpes simplex virus 1 and human cytomegalovirus infections. | MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.
Sloan E, Orr A, Everett RD., Free PMC Article | 05/13/2017 |
| Case Report: manifestations of interstitial lung disease in adult dermatomyositis patient with anti-NPX2 autoantibodies. | Interstitial lung disease in an adult patient with dermatomyositis and anti-NXP2 autoantibody.
Gossez M, Levesque M, Khouatra C, Cottin V, Garnier L, Fabien N., Free PMC Article | 03/12/2016 |
| Downregulation of NXP2/MORC3 by use of two independent short hairpin RNAs reduced virus titers in low-multiplicity infections. Analysis of viral RNA in high-multiplicity infections showed a reduction of viral RNA and mRNA after NXP2/MORC3 downregulation. | The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication.
Ver LS, Marcos-Villar L, Landeras-Bueno S, Nieto A, Ortín J., Free PMC Article | 12/5/2015 |
| Case Report: Pemphigus foliaceus associated with anti-NXP2 autoantibody-positive amyopathic dermatomyositis. | Pemphigus foliaceus associated with anti-NXP2 autoantibody-positive dermatomyositis.
Fujimoto N, Takayama S, Hamaguchi Y, Fujimoto M, Tanaka T. | 03/21/2015 |
| These studies demonstrate that anti-NXP-2 and anti-TIF-1gamma antibodies are frequent DM specificities (found in 55% of patients) and are present in most patients with cancer-associated dermatomhyositis. | Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ.
Fiorentino DF, Chung LS, Christopher-Stine L, Zaba L, Li S, Mammen AL, Rosen A, Casciola-Rosen L., Free PMC Article | 01/4/2014 |
| An anti-MJ antibody that recognizes NXP-2 was found to be a useful biomarker in dermatomyositis-polymyositis patients. | Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis.
Ceribelli A, Fredi M, Taraborelli M, Cavazzana I, Franceschini F, Quinzanini M, Tincani A, Ross SJ, Chan JY, Pauley BA, Chan EK, Satoh M., Free PMC Article | 05/25/2013 |
| Anti-NXP2 Ab may be associated with adult idiopathic inflammatory myopathies with malignancy. | Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy.
Ichimura Y, Matsushita T, Hamaguchi Y, Kaji K, Hasegawa M, Tanino Y, Inokoshi Y, Kawai K, Kanekura T, Habuchi M, Igarashi A, Sogame R, Hashimoto T, Koga T, Nishino A, Ishiguro N, Sugimoto N, Aoki R, Ando N, Abe T, Kanda T, Kuwana M, Takehara K, Fujimoto M. | 06/2/2012 |
| MORC3 colocalizes with PML by a two-step molecular mechanism. | Two-step colocalization of MORC3 with PML nuclear bodies.
Mimura Y, Takahashi K, Kawata K, Akazawa T, Inoue N. | 09/6/2010 |
| When tethered to a promoter by fusion to Gal4, NXP-2 repressed transcription, consistent with a role for NXP-2 in SUMO-mediated repression | NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.
Rosendorff A, Sakakibara S, Lu S, Kieff E, Xuan Y, DiBacco A, Shi Y, Shi Y, Gill G., Free PMC Article | 01/21/2010 |
| MORC3 (microrchidia3)-ATPase activated p53 and induced cellular senescence in normal fibroblasts but not p53-/- fibroblasts | Dynamic regulation of p53 subnuclear localization and senescence by MORC3.
Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Zinn AR, Shime H, Inoue N., Free PMC Article | 01/21/2010 |
| determination of nuclear matrix-binding, RNA-binding, and coiled-coil domans | The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains.
Kimura Y, Sakai F, Nakano O, Kisaki O, Sugimoto H, Sawamura T, Sadano H, Osumi T. | 01/21/2010 |