Exosomal circMACF1 drives PI3K/AKT/mTOR-mediated autophagy suppression in laryngeal squamous cell carcinoma. | Exosomal circMACF1 drives PI3K/AKT/mTOR-mediated autophagy suppression in laryngeal squamous cell carcinoma. Zhu Y, Duan C, Gui Y, Chen D, Su X. | 03/21/2024 |
LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating beta-catenin/c-Myc signaling. | LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling. Wang Y, Tong H, Wang J, Hu L, Huang Z. | 02/9/2024 |
CircMACF1 alleviates myocardial fibrosis after acute myocardial infarction by suppressing cardiac fibroblast activation via the miR-16-5p/SMAD7 axis. | CircMACF1 alleviates myocardial fibrosis after acute myocardial infarction by suppressing cardiac fibroblast activation via the miR-16-5p/SMAD7 axis. Wang Y, Liu Y, Fei A, Tan L., Free PMC Article | 09/23/2023 |
Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism. | Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism. Salem D, Fecek RJ., Free PMC Article | 06/30/2023 |
The role of MACF1 on acute myeloid leukemia cell proliferation is involved in Runx2-targeted PI3K/Akt signaling. | The role of MACF1 on acute myeloid leukemia cell proliferation is involved in Runx2-targeted PI3K/Akt signaling. Wang P, Zhang J, Zhang H, Zhang F. | 02/24/2023 |
THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes. | THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes. Ustianowski P, Malinowski D, Czerewaty M, Safranow K, Tarnowski M, Dziedziejko V, Pawlik A., Free PMC Article | 02/11/2023 |
Lissencephaly with Brainstem Hypoplasia and Dysplasia: Think MACF1. | Lissencephaly with Brainstem Hypoplasia and Dysplasia: Think MACF1. Bölsterli BK, Steindl K, Kottke R, Steinfeld R, Boltshauser E. | 04/16/2022 |
Expression and Clinical Significance of Microtubule-Actin Cross-Linking Factor 1 in Serous Ovarian Cancer. | Expression and Clinical Significance of Microtubule-Actin Cross-Linking Factor 1 in Serous Ovarian Cancer. Liu L, Hu K, Zeng Z, Xu C, Lv J, Lin Z, Wen B. | 11/27/2021 |
Deubiquitylation and stabilization of Acf7 by ubiquitin carboxylterminal hydrolase 14 (USP14) is critical for NSCLC migration. | Deubiquitylation and stabilization of Acf7 by ubiquitin carboxylterminal hydrolase 14 (USP14) is critical for NSCLC migration. Yan G, Liu NA, Wang J, Tian J, Liu H, Li S, Liu W, Li X, Li K, Wang H. | 10/30/2021 |
Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation. | Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation. Zhao F, Ma X, Qiu W, Wang P, Zhang R, Chen Z, Su P, Zhang Y, Li D, Ma J, Yang C, Chen L, Yin C, Tian Y, Hu L, Li Y, Zhang G, Wu X, Qian A., Free PMC Article | 03/6/2021 |
New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing. | New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing. Jaillard S, Bell K, Akloul L, Walton K, McElreavy K, Stocker WA, Beaumont M, Harrisson C, Jääskeläinen T, Palvimo JJ, Robevska G, Launay E, Satié AP, Listyasari N, Bendavid C, Sreenivasan R, Duros S, van den Bergen J, Henry C, Domin-Bernhard M, Cornevin L, Dejucq-Rainsford N, Belaud-Rotureau MA, Odent S, Ayers KL, Ravel C, Tucker EJ, Sinclair AH. | 11/28/2020 |
Missense mutation in the MACF1 gene is associated with congenital myasthenia. | MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses. Oury J, Liu Y, Töpf A, Todorovic S, Hoedt E, Preethish-Kumar V, Neubert TA, Lin W, Lochmüller H, Burden SJ., Free PMC Article | 04/11/2020 |
MACF1 might lose the control of the whole cytoskeleton system, synapse might change and Alzheimer's disease might develop | Alteration of scaffold: Possible role of MACF1 in Alzheimer's disease pathogenesis. Wang X, Qi Y, Zhou X, Zhang G, Fu C. | 02/22/2020 |
Three de novo variants in MACF1 have been observed in large schizophrenia cohorts. | MACF1 Mutations Encoding Highly Conserved Zinc-Binding Residues of the GAR Domain Cause Defects in Neuronal Migration and Axon Guidance. Dobyns WB, Aldinger KA, Ishak GE, Mirzaa GM, Timms AE, Grout ME, Dremmen MHG, Schot R, Vandervore L, van Slegtenhorst MA, Wilke M, Kasteleijn E, Lee AS, Barry BJ, Chao KR, Szczałuba K, Kobori J, Hanson-Kahn A, Bernstein JA, Carr L, D'Arco F, Miyana K, Okazaki T, Saito Y, Sasaki M, Das S, Wheeler MM, Bamshad MJ, Nickerson DA, University of Washington Center for Mendelian Genomics, Center for Mendelian Genomics at the Broad Institute of MIT and Harvard, Engle EC, Verheijen FW, Doherty D, Mancini GMS., Free PMC Article | 05/18/2019 |
In this study, uncontrolled Diabetes mellitus (DM) had a remote impact on different components of the platelet transcriptome. Increased expression of MACF1, together with supporting predicted mRNA-miRNA interactions as well as reduced expression of RNYs in platelets, may reflect subclinical platelet activation in uncontrolled DM. | Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome. Nührenberg TG, Cederqvist M, Marini F, Stratz C, Grüning BA, Trenk D, Binder H, Gilsbach R, Neumann FJ, Hein L., Free PMC Article | 03/23/2019 |
MACF1 overexpression triggered a drastic increase in osteogenic gene expression, alkaline phosphatase activity, and matrix mineralization in vitro. Mouse calvarial thickness, mineral apposition rate, and osteogenic marker protein expression were significantly enhanced by local transfection. In addition, MACF1 overexpression promoted beta-catenin expression and signaling. | MACF1 Overexpression by Transfecting the 21 kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation. Zhang Y, Yin C, Hu L, Chen Z, Zhao F, Li D, Ma J, Ma X, Su P, Qiu W, Yang C, Wang P, Li S, Zhang G, Wang L, Qian A, Xian CJ. | 03/16/2019 |
Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in patients. | ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X., Free PMC Article | 12/1/2018 |
Study summarized the physiological role of MACF1 as well as its pathological one in various cancers. MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer. | Microtubule actin cross-linking factor 1, a novel potential target in cancer. Miao Z, Ali A, Hu L, Zhao F, Yin C, Chen C, Yang T, Qian A., Free PMC Article | 10/7/2017 |
in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends. | Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7. Noordstra I, Liu Q, Nijenhuis W, Hua S, Jiang K, Baars M, Remmelzwaal S, Martin M, Kapitein LC, Akhmanova A. | 08/5/2017 |
MACF1b may contribute to the genetic etiology and mechanistic causation of Parkinson's disease. | Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Wang X, Li N, Xiong N, You Q, Li J, Yu J, Qing H, Wang T, Cordell HJ, Isacson O, Vance JM, Martin ER, Zhao Y, Cohen BM, Buttner EA, Lin Z. | 07/8/2017 |
ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments. | The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics. Ning W, Yu Y, Xu H, Liu X, Wang D, Wang J, Wang Y, Meng W. | 06/24/2017 |
the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas | Microtubule actin cross-linking factor 1, a novel target in glioblastoma. Afghani N, Mehta T, Wang J, Tang N, Skalli O, Quick QA., Free PMC Article | 04/8/2017 |
Duplication in the microtubule-actin cross-linking factor 1 gene causes neuromuscular diseases. | Duplication in the microtubule-actin cross-linking factor 1 gene causes a novel neuromuscular condition. Jørgensen LH, Mosbech MB, Færgeman NJ, Graakjaer J, Jacobsen SV, Schrøder HD., Free PMC Article | 11/14/2015 |
uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability | ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions. Margaron Y, Fradet N, Côté JF., Free PMC Article | 03/30/2013 |
ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2. | ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Zaoui K, Benseddik K, Daou P, Salaün D, Badache A., Free PMC Article | 11/27/2010 |