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    FOLR1 folate receptor alpha [ Homo sapiens (human) ]

    Gene ID: 2348, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    PARP-1, EpCAM, and FRalpha as potential targets for intraoperative detection and delineation of endometriosis: a quantitative tissue expression analysis.

    PARP-1, EpCAM, and FRα as potential targets for intraoperative detection and delineation of endometriosis: a quantitative tissue expression analysis.
    Belmonte B, Di Lorenzo G, Mangogna A, Bortot B, Bertolazzi G, Sammataro S, Merighi S, Martorana A, Zito G, Romano F, Giorgiutti A, Bottin C, Zanconati F, Romano A, Ricci G, Biffi S., Free PMC Article

    09/10/2024
    Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.

    Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.
    Hussain N, Malik S, Faiz T, Shafqat F, Khan AA, Haq TU, Ali W, Aziz T, Alharbi M, Alshammari A, Alasmari AF.

    12/27/2023
    Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1.

    Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1.
    Zhao J, Lin E, Bai Z, Jia Y, Wang B, Dai Y, Zhuo W, Zeng G, Liu X, Cai C, Li P, Zou B, Li J., Free PMC Article

    12/18/2023
    Folate receptor alpha is widely expressed and a potential therapeutic target in uterine and ovarian carcinosarcoma.

    Folate receptor alpha is widely expressed and a potential therapeutic target in uterine and ovarian carcinosarcoma.
    Saito A, Nishikawa T, Yoshida H, Mizoguchi C, Kitadai R, Yamamoto K, Yazaki S, Kojima Y, Ishikawa M, Kato T, Yonemori K.

    09/6/2023
    Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.

    Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.
    Xie S, Louis Sam Titus ASC, Mohan C.

    03/7/2023
    Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes.

    Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes.
    Bax HJ, Chauhan J, Stavraka C, Santaolalla A, Osborn G, Khiabany A, Grandits M, López-Abente J, Palhares LCGF, Chan Wah Hak C, Robinson A, Pope A, Woodman N, Naceur-Lombardelli C, Malas S, Coumbe JEM, Nakamura M, Laddach R, Mele S, Crescioli S, Black AM, Lombardi S, Canevari S, Figini M, Sayasneh A, Tsoka S, FitzGerald K, Gillett C, Pinder S, Van Hemelrijck M, Kristeleit R, Ghosh S, Montes A, Spicer J, Karagiannis SN, Josephs DH., Free PMC Article

    02/28/2023
    High Expression of Folate Receptor Alpha (FOLR1) is Associated With Aggressive Tumor Behavior, Poor Response to Chemoradiotherapy, and Worse Survival in Rectal Cancer.

    High Expression of Folate Receptor Alpha (FOLR1) is Associated With Aggressive Tumor Behavior, Poor Response to Chemoradiotherapy, and Worse Survival in Rectal Cancer.
    Chen CI, Li WS, Chen HP, Liu KW, Tsai CJ, Hung WJ, Yang CC., Free PMC Article

    12/3/2022
    High expression of folate receptor alpha is associated with poor prognosis in patients with cervical cancer.

    High expression of folate receptor alpha is associated with poor prognosis in patients with cervical cancer.
    Yazaki S, Kojima Y, Yoshida H, Takamizawa S, Kitadai R, Nishikawa T, Shimoi T, Sudo K, Saito A, Okuma HS, Tanioka M, Noguchi E, Uno M, Ishikawa M, Kato T, Fujiwara Y, Ohe Y, Yonemori K., Free PMC Article

    11/12/2022
    Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.", trans "FOLR1FOLR2.

    Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.
    Song X, Huang P, Wang T, Zhang S, Chen L, Qin J., Free PMC Article

    05/21/2022
    Emerging roles for folate receptor FOLR1 in signaling and cancer.

    Emerging roles for folate receptor FOLR1 in signaling and cancer.
    Nawaz FZ, Kipreos ET., Free PMC Article

    04/30/2022
    CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.

    CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.
    Cao X, Wolf A, Kim SE, Cabrera RM, Wlodarczyk BJ, Zhu H, Parker M, Lin Y, Steele JW, Han X, Ramaekers VT, Steinfeld R, Finnell RH, Lei Y., Free PMC Article

    03/19/2022
    Folate receptor alpha increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.

    Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.
    Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, Uenaka T, Kato R, Nakagawa K., Free PMC Article

    02/12/2022
    Cerebral folate transporter deficiency syndrome in three siblings: Why genetic testing for developmental and epileptic encephalopathies should be performed early and include the FOLR1 gene.

    Cerebral folate transporter deficiency syndrome in three siblings: Why genetic testing for developmental and epileptic encephalopathies should be performed early and include the FOLR1 gene.
    Brunetti S, Malerba L, Giordano L, Parrini E, Guerrini R, Palumbo G, Parazzini C, Bestetti I, Accorsi P.

    01/15/2022
    Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.

    Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.
    O'Connor C, Wallace-Povirk A, Ning C, Frühauf J, Tong N, Gangjee A, Matherly LH, Hou Z., Free PMC Article

    10/16/2021
    Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells.

    Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells.
    Chu H, Wu C, Zhao Q, Sun R, Yang K, Zhao B, Liu Y, Liang Z, Zhong S, Zhang L, Zhang Y.

    10/2/2021
    Correlation between the expression of folate receptor alpha (FRalpha) and clinicopathological features in patients with lung adenocarcinoma.

    Correlation between the expression of folate receptor alpha (FRα) and clinicopathological features in patients with lung adenocarcinoma.
    Tamura N, Fujiwara Y, Hashimoto T, Shiraishi H, Kitano S, Shimizu T, Kuwano K, Yamamoto N, Motoi N.

    09/4/2021
    Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT.

    Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT.
    Jia L, Li J, Li P, Liu D, Li J, Shen J, Zhu B, Ma C, Zhao T, Lan R, Dang L, Li W, Sun S., Free PMC Article

    08/7/2021
    Identification of proteins related with pemetrexed resistance by iTRAQ and PRM-based comparative proteomic analysis and exploration of IGF2BP2 and FOLR1 functions in non-small cell lung cancer cells.

    Identification of proteins related with pemetrexed resistance by iTRAQ and PRM-based comparative proteomic analysis and exploration of IGF2BP2 and FOLR1 functions in non-small cell lung cancer cells.
    Han X, Chen L, Hu Z, Chen L, Sun P, Wang Y, Liu Y.

    07/3/2021
    A systematic review and meta-analysis of higher expression of folate receptor alpha (FOLR1) predicts poor cancer prognosis.

    A systematic review and meta-analysis of higher expression of folate receptor alpha (FOLR1) predicts poor cancer prognosis.
    Liu Y, Lian T, Yao Y.

    04/17/2021
    Decreased placental folate transporter expression and activity in first and second trimester in obese mothers.

    Decreased placental folate transporter expression and activity in first and second trimester in obese mothers.
    Jessel RH, Rosario FJ, Chen YY, Erickson K, Teal SB, Kramer A, Cotton E, Ryan S, Jansson T, Powell TL.

    02/27/2021
    Comparison of a Short Versus Long Stokes Shift Near-Infrared Dye During Intraoperative Molecular Imaging.

    Comparison of a Short Versus Long Stokes Shift Near-Infrared Dye During Intraoperative Molecular Imaging.
    Corbett CJ, Frenzel Sulyok LG, Predina JD, Newton AD, Bryski MG, Xia L, Stadanlick J, Shin MH, Mahalingam SM, Low PS, Singhal S., Free PMC Article

    01/23/2021
    Polydopamine-PEG-Folic Acid Conjugate Film Engineered TiO2 Nanotube Arrays for Photoelectrochemical Sensing of Folate Binding Protein.

    Polydopamine-PEG-Folic Acid Conjugate Film Engineered TiO(2) Nanotube Arrays for Photoelectrochemical Sensing of Folate Binding Protein.
    Fan B, Fan Q, Hu L, Cui M, Wang X, Ma H, Wei Q.

    09/26/2020
    High serum FOLR1 levels are associated with ovarian cancer.

    Serum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance.
    Farran B, Albayrak S, Abrams J, Tainsky MA, Levin NK, Morris R, Matherly LH, Ratnam M, Winer I., Free PMC Article

    05/23/2020
    An all-atom bilayer, including 35 different lipid types asymmetrically distributed among the two monolayers, is suggested as a model neoplastic cell membrane. One molecule of folate receptor alpha is anchored into its outer leaflet, and the behavior of the system is explored by atomistic molecular dynamics simulations.

    Characteristics of a Folate Receptor-α Anchored into a Multilipid Bilayer Obtained from Atomistic Molecular Dynamics Simulations.
    Gocheva G, Ivanova N, Iliev S, Petrova J, Madjarova G, Ivanova A.

    01/25/2020
    Folate Receptor Alpha Expression in Platinum Resistant/Refractory Ovarian Carcinomas and Primary Endocervical Adenocarcinomas.

    Folate Receptor Alpha Expression in Platinum Resistant/Refractory Ovarian Carcinomas and Primary Endocervical Adenocarcinomas.
    Rubinsak LA, Cohen C, Khanna N, Horowitz IR, Hanley KZ.

    08/10/2019
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