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    Neil3 nei like 3 (E. coli) [ Mus musculus (house mouse) ]

    Gene ID: 234258, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion.

    Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion.
    Bugaj AM, Kunath N, Saasen VL, Fernandez-Berrocal MS, Vankova A, Sætrom P, Bjørås M, Ye J.

    04/17/2024
    WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.

    WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.
    Dickinson K, Hammond L, Akpa M, Chu LL, Lalonde CT, Goumba A, Goodyer P.

    02/24/2023
    NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway.

    NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway.
    Lai HH, Hung LY, Yen CJ, Hung HC, Chen RY, Ku YC, Lo HT, Tsai HW, Lee YP, Yang TH, Chen YY, Huang YS, Huang W.

    11/19/2022
    Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model.

    Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model.
    Huskova A, Dinesh DC, Srb P, Boura E, Veverka V, Silhan J., Free PMC Article

    10/22/2022
    NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.

    NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.
    Karlsen TR, Kong XY, Holm S, Quiles-Jiménez A, Dahl TB, Yang K, Sagen EL, Skarpengland T, S Øgaard JD, Holm K, Vestad B, Olsen MB, Aukrust P, Bjørås M, Hov JR, Halvorsen B, Gregersen I., Free PMC Article

    01/1/2022
    Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3.

    Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3.
    Imani Nejad M, Housh K, Rodriguez AA, Haldar T, Kathe S, Wallace SS, Eichman BF, Gates KS., Free PMC Article

    11/21/2020
    NEIL1 and NEIL3 may protect cells against cytotoxic and mutagenic effects of NM-Fapy-dG, but NEIL1 may have a unique role in initiation of base excision repair of AFB1-Fapy-dG

    Processing of N(5)-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3.
    Minko IG, Christov PP, Li L, Stone MP, McCullough AK, Lloyd RS., Free PMC Article

    07/20/2019
    Results suggest a novel role for the DNA glycosylase Neil3 in atherogenesis in balancing lipid metabolism and macrophage function, potentially independently of genome-wide canonical base excision repair of oxidative DNA damage.

    Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
    Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A, Folkersen L, Ueland T, Berge RK, Hansson GK, Biessen EA, Halvorsen B, Bjørås M, Aukrust P., Free PMC Article

    06/2/2018
    Data suggest that neurogenesis induced by Neil3 repair of oxidative DNA damage protects against prion disease during the clinical phase.

    Neil3 induced neurogenesis protects against prion disease during the clinical phase.
    Jalland CM, Scheffler K, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis MA., Free PMC Article

    06/2/2018
    NEIL3-dependent modulation of DNA methylation regulates cardiac fibroblast proliferation and thereby affects extracellular matrix modulation after myocardial infarction.

    NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
    Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P, Yndestad A, Aukrust P, Bjørås M, Finsen AV.

    11/25/2017
    These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity.

    Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
    Massaad MJ, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, Glauzy S, Olson BG, Morbach H, Ohsumi TK, Schmitz K, Kyriacos M, Kane J, Torisu K, Nakabeppu Y, Notarangelo LD, Chouery E, Megarbane A, Kang PB, Al-Idrissi E, Aldhekri H, Meffre E, Mizui M, Tsokos GC, Manis JP, Al-Herz W, Wallace SS, Geha RS., Free PMC Article

    09/2/2017
    one role for Neil3 and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA.

    Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context.
    Zhou J, Liu M, Fleming AM, Burrows CJ, Wallace SS., Free PMC Article

    11/30/2013
    Structural insight into the substrate specificity and marked preference of Neil3 for ssDNA.

    Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA.
    Liu M, Imamura K, Averill AM, Wallace SS, Doublié S., Free PMC Article

    08/3/2013
    Our data support the involvement of Neil3 in removal of replication blocks in proliferating cells.

    Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress.
    Rolseth V, Krokeide SZ, Kunke D, Neurauter CG, Suganthan R, Sejersted Y, Hildrestrand GA, Bjørås M, Luna L.

    06/22/2013
    Neil3-dependent repair of oxidative DNA damage in neural stem/progenitor cells is required for maintenance of adult neurogenesis to counteract the age-associated deterioration of cognitive performance.

    Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells.
    Regnell CE, Hildrestrand GA, Sejersted Y, Medin T, Moldestad O, Rolseth V, Krokeide SZ, Suganthan R, Luna L, Bjørås M, Bergersen LH.

    03/2/2013
    Here we report the construction of bicistronic expression vectors for expressing in Escherichia coli the full-length mouse Neil3 (MmuNeil3), its glycosylase domain (MmuNeil3Delta324), as well as the glycosylase domain of human Neil3 (NEIL3Delta324).

    Expression and purification of active mouse and human NEIL3 proteins.
    Liu M, Bandaru V, Holmes A, Averill AM, Cannan W, Wallace SS., Free PMC Article

    12/22/2012
    Neil3 exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells

    Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
    Sejersted Y, Hildrestrand GA, Kunke D, Rolseth V, Krokeide SZ, Neurauter CG, Suganthan R, Atneosen-Åsegg M, Fleming AM, Saugstad OD, Burrows CJ, Luna L, Bjørås M., Free PMC Article

    01/28/2012
    Neil3 plays a role in repairing 2,6-diamino-4-hydroxy-5-formamidopyrimidine in vivo.

    The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.
    Liu M, Bandaru V, Bond JP, Jaruga P, Zhao X, Christov PP, Burrows CJ, Rizzo CJ, Dizdaroglu M, Wallace SS., Free PMC Article

    05/3/2010
    NEIL3 is specifically expressed in brain areas where neurogenesis takes place during development and that its expression is tightly regulated both temporally and spatially. NEIL3 seems to be upregulated in tumor tissues compared to normal tissues.

    Expression patterns of Neil3 during embryonic brain development and neoplasia.
    Hildrestrand GA, Neurauter CG, Diep DB, Castellanos CG, Krauss S, Bjørås M, Luna L., Free PMC Article

    01/21/2010
    NEIL3 is localized in the nuclei; Neil3 mRNA was selectively expressed in thymus, spleen and bone marrow

    Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein.
    Torisu K, Tsuchimoto D, Ohnishi Y, Nakabeppu Y.

    01/21/2010
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