| Undifferentiated Round Cell Sarcoma With CRTC1::SS18 Fusion: Expanding Clinicopathologic Features of a Rare Translocation Sarcoma With Prominent Desmoplastic Stroma. | Undifferentiated Round Cell Sarcoma With CRTC1::SS18 Fusion: Expanding Clinicopathologic Features of a Rare Translocation Sarcoma With Prominent Desmoplastic Stroma.
Warmke LM, Strike SA, Fayad LM, Ahlawat S, Liu YJ, Mata DA, Rooper L, Baraban E, Zou YS, Gross JM. | 09/30/2024 |
| Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens. | Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens.
Yamanaka S, Suzuki S, Ito H, Sivasundaram K, Hanamura I, Okubo I, Yoshikawa K, Ono S, Takahara T, Satou A, Tsuzuki T, Ueda R, Ogawa T, Fujimoto Y., Free PMC Article | 02/4/2023 |
| Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases. | Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases.
Hanna J, Ko JS, Billings SD, Boivin F, Beaudoux O, Pissaloux D, Tirode F, Laga A, Fletcher CDM, de la Fouchardiere A. | 10/22/2022 |
| Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma. | Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.
Yang Y, Bolomsky A, Oellerich T, Chen P, Ceribelli M, Häupl B, Wright GW, Phelan JD, Huang DW, Lord JW, Van Winkle CK, Yu X, Wisniewski J, Wang JQ, Tosto FA, Beck E, Wilson K, McKnight C, Travers J, Klumpp-Thomas C, Smith GA, Pittaluga S, Maric I, Kazandjian D, Thomas CJ, Young RM., Free PMC Article | 10/8/2022 |
| Salivary mucoepidermoid carcinoma: histological variants, grading systems, CRTC1/3-MAML2 fusions, and clinicopathological features. | Salivary mucoepidermoid carcinoma: histological variants, grading systems, CRTC1/3-MAML2 fusions, and clinicopathological features.
Nakano S, Okumura Y, Murase T, Nagao T, Kusafuka K, Urano M, Yamamoto H, Kano S, Tsukahara K, Okami K, Kawakita D, Nagao T, Hanai N, Iwai H, Kawata R, Tada Y, Nibu KI, Inagaki H. | 04/2/2022 |
| Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma. | Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma.
Ni W, Chen Z, Zhou X, Yang R, Yu M, Lu J, Kaye FJ, Wu L., Free PMC Article | 03/5/2022 |
| The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma. | The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma.
Chen Z, Ni W, Li JL, Lin S, Zhou X, Sun Y, Li JW, Leon ME, Hurtado MD, Zolotukhin S, Liu C, Lu J, Griffin JD, Kaye FJ, Wu L., Free PMC Article | 01/22/2022 |
| TORC1 selectively regulates synaptic maturation and input convergence in the developing visual system. | TORC1 selectively regulates synaptic maturation and input convergence in the developing visual system.
Gobert D, Schohl A, Kutsarova E, Ruthazer ES. | 10/30/2021 |
| Mycobacterium tuberculosis Rv3034c regulates mTORC1 and PPAR-gamma dependant pexophagy mechanism to control redox levels in macrophages. | Mycobacterium tuberculosis Rv3034c regulates mTORC1 and PPAR-γ dependant pexophagy mechanism to control redox levels in macrophages.
Ganguli G, Pattanaik KP, Jagadeb M, Sonawane A. | 08/7/2021 |
| Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity. | Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity.
Jang YG, Choi Y, Jun K, Chung J., Free PMC Article | 07/3/2021 |
| Structural Insights into the Interaction Between CRTCs and 14-3-3. | Structural Insights into the Interaction Between CRTCs and 14-3-3.
Chen H, Zhang H, Chen P, Xiang S. | 06/19/2021 |
| mTORC1 silencing during intestinal epithelial Caco-2 cell differentiation is mediated by the activation of the AMPK/TSC2 pathway. | mTORC1 silencing during intestinal epithelial Caco-2 cell differentiation is mediated by the activation of the AMPK/TSC2 pathway.
Kaur H, Moreau R. | 05/15/2021 |
| Study identified a methylation change during the first month of psychotropic treatment in the CRTC1 gene, which was associated with early weight gain during the same period. This epigenetic modulation was dependent on a genetic variant (rs4808844A>G) in the same genetic region, which plays a considerable regulatory role. | Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients.
Delacrétaz A, Glatard A, Dubath C, Gholam-Rezaee M, Sanchez-Mut JV, Gräff J, von Gunten A, Conus P, Eap CB., Free PMC Article | 07/25/2020 |
| These data suggest that increased CRTC1 in maladaptive hypertrophy presents a compensatory mechanism to delay disease progression in part by enhancing Rgs2 gene transcription. | Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.
Morhenn K, Quentin T, Wichmann H, Steinmetz M, Prondzynski M, Söhren KD, Christ T, Geertz B, Schröder S, Schöndube FA, Hasenfuss G, Schlossarek S, Zimmermann WH, Carrier L, Eschenhagen T, Cardinaux JR, Lutz S, Oetjen E. | 01/11/2020 |
| Our data support the known role of CRCT1 regulating energy metabolism in brain. Here, we highlight relevance of CRTC1 regulation in blood and adipose tissue | (Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution.
Rohde K, Keller M, la Cour Poulsen L, Rønningen T, Stumvoll M, Tönjes A, Kovacs P, Horstmann A, Villringer A, Blüher M, Böttcher Y., Free PMC Article | 12/14/2019 |
| Case Reports: identify a novel recurrent gene fusion, CRTC1-SS18, in undifferentiated small round cell sarcoma. | Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion.
Alholle A, Karanian M, Brini AT, Morris MR, Kannappan V, Niada S, Niblett A, Ranchère-Vince D, Pissaloux D, Delfour C, Maran-Gonzalez A, Antonescu CR, Sumathi V, Tirode F, Latif F., Free PMC Article | 11/2/2019 |
| Pancreatic mucoepidermoid carcinoma does not have CRTC1/3-MAML2 fusion gene and MAML2 gene rearrangement. | "Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features.
Saeki K, Ohishi Y, Matsuda R, Mochidome N, Miyasaka Y, Yamamoto H, Koga Y, Maehara Y, Nakamura M, Oda Y. | 09/7/2019 |
| Two cases of breast mucoepidermoid carcinomas harboring CRTC1-MAML2 fusions are reported | CRTC1-MAML2 fusion in mucoepidermoid carcinoma of the breast.
Bean GR, Krings G, Otis CN, Solomon DA, García JJ, van Zante A, Camelo-Piragua S, van Ziffle J, Chen YY. | 05/11/2019 |
| mTORC1 hyperactivation in melanocytes results in hypopigmentation. | Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation.
Yang F, Yang L, Wataya-Kaneda M, Yoshimura T, Tanemura A, Katayama I. | 03/16/2019 |
| CRTC1-TRIM11 fusion appears to be specific of an unpigmented nodular tumor combining a melanocytic phenotype and low-grade tumor behavior. | Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion: Report of 5 Cases Resembling Clear Cell Sarcoma.
Cellier L, Perron E, Pissaloux D, Karanian M, Haddad V, Alberti L, de la Fouchardière A. | 03/16/2019 |
| LINC00473 acts as a promising biomarker and therapeutic target for human CRTC1-MAML2-positive Mucoepidermoid carcinomas. | CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells.
Chen Z, Lin S, Li JL, Ni W, Guo R, Lu J, Kaye FJ, Wu L., Free PMC Article | 03/9/2019 |
| Pharmacological inhibition of mTORC1 by rapamycin in PHA-stimulated PBL reduced viral replication to the level found in unstimulated lymphocytes, indicating that mTORC1 activity supports MV replication as a proviral host factor. | APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
Tiwarekar V, Wohlfahrt J, Fehrholz M, Scholz CJ, Kneitz S, Schneider-Schaulies J., Free PMC Article | 08/25/2018 |
| SNP located in CRTC1 has been shown in GWAS studies to be significantly associated with the risk of Barrett's esophagus. | Biomarkers of Barrett's Esophagus: From the Laboratory to Clinical Practice.
Konda VJA, Souza RF., Free PMC Article | 08/4/2018 |
| This work reveals a regulatory circuit in which SIK1 suppresses gluconeogenic gene transcription by inducing ubiquitination and degradation of CRTC1. | Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1.
Gao WW, Tang HV, Cheng Y, Chan CP, Chan CP, Jin DY. | 06/2/2018 |
| CRTC1 negatively regulates lipogenic gene expression in liver. | The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation.
Kim H., Free PMC Article | 05/19/2018 |