| GPR41 and GPR43 regulate CD8[+] T cell priming during herpes simplex virus type 1 infection. | GPR41 and GPR43 regulate CD8(+) T cell priming during herpes simplex virus type 1 infection.
Lee AR, Wilson KR, Clarke M, Engel S, Tscharke DC, Gebhardt T, Bedoui S, Bachem A., Free PMC Article | 03/27/2024 |
| G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Galphai/o and downstream Smad2/3 and ERK1/2 phosphorylation. | G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gα(i/o) and downstream Smad2/3 and ERK1/2 phosphorylation.
Ren Z, Pan X, Li J, Dong X, Tu X, Pan LL, Sun J. | 05/10/2023 |
| The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity. | The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.
Solas M, Zamarbide M, Ardanaz CG, Ramírez MJ, Pérez-Mediavilla A., Free PMC Article | 11/26/2022 |
| Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior. | Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Cook TM, Gavini CK, Jesse J, Aubert G, Gornick E, Bonomo R, Gautron L, Layden BT, Mansuy-Aubert V., Free PMC Article | 03/26/2022 |
| Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3. | Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.
Shimizu H, Masujima Y, Ushiroda C, Mizushima R, Taira S, Ohue-Kitano R, Kimura I., Free PMC Article | 10/31/2020 |
| FFAR3 is expressed primarily in neurons with a vasoconstrictor phenotype. | Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.
Colina C, Puhl HL 3rd, Ikeda SR., Free PMC Article | 10/19/2019 |
| Gpr41 KO mice have hypertension of a vascular origin. | Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.
Natarajan N, Hori D, Flavahan S, Steppan J, Flavahan NA, Berkowitz DE, Pluznick JL., Free PMC Article | 02/10/2018 |
| the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire expression | Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.
Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. | 11/25/2017 |
| that GPR41 and its ligands, short-chain fatty acids, may play an important role in the fine-tuning of insulin secretion in fed and fasting states | GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.
Veprik A, Laufer D, Weiss S, Rubins N, Walker MD. | 09/23/2017 |
| Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2-synapsin 2 | Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.
Inoue D, Kimura I, Wakabayashi M, Tsumoto H, Ozawa K, Hara T, Takei Y, Hirasawa A, Ishihama Y, Tsujimoto G. | 08/29/2016 |
| mediates beta cell glucose stimulated insulin secretion through Galphai/o sensitive pathway | FFAR3 modulates insulin secretion and global gene expression in mouse islets.
Priyadarshini M, Layden BT., Free PMC Article | 08/27/2016 |
| Results indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system | Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.
Nøhr MK, Egerod KL, Christiansen SH, Gille A, Offermanns S, Schwartz TW, Møller M. | 12/19/2015 |
| FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins. | Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S. | 04/11/2015 |
| Data from transgenic mice suggest that Ffar3/Gpr41 and Ffar2/Gpr43 both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar3/Gpr41 appears to play this role alone in enteric neurons and Ffar2/Gpr43 alone in enteric leukocytes. | GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.
Nøhr MK, Pedersen MH, Gille A, Egerod KL, Engelstoft MS, Husted AS, Sichlau RM, Grunddal KV, Poulsen SS, Han S, Jones RM, Offermanns S, Schwartz TW. | 11/30/2013 |
| Short-chain fatty acids activate GPR41 and on intestinal epithelial cells, leading to mitogen-activated protein kinase signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice. | Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.
Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH. | 09/28/2013 |
| Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3 | Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.
Hudson BD, Tikhonova IG, Pandey SK, Ulven T, Milligan G., Free PMC Article | 02/9/2013 |
| GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins | GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.
Bahar Halpern K, Veprik A, Rubins N, Naaman O, Walker MD., Free PMC Article | 09/22/2012 |
| Short chain fatty acids and ketone bodies directly regulate GPR41-mediated sympathetic nervous system activity and thereby control body energy expenditure in maintaining metabolic homeostasis. | Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G., Free PMC Article | 07/16/2011 |
| In this review, the mechanism of receptor activation, pharmacology, and the physiological functions of the fatty acid binding receptors GPR40, GPR41, GPR43, and GPR119 are discussed. | Fatty acid binding receptors and their physiological role in type 2 diabetes.
Swaminath G. | 01/21/2010 |
| Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut microbiota | Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.
Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI., Free PMC Article | 01/21/2010 |
| Acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43, but not through GPCR41. | Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.
Hong YH, Nishimura Y, Hishikawa D, Tsuzuki H, Miyahara H, Gotoh C, Choi KC, Feng DD, Chen C, Lee HG, Katoh K, Roh SG, Sasaki S. | 01/21/2010 |