| WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice. | WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice.
Xu D, Zhi Y, Liu X, Guan L, Yu J, Zhang D, Zhang W, Wang Y, Tao W, Xu Z., Free PMC Article | 08/31/2023 |
| WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation. | WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation.
Wang YS, Chen C, Ahmad MJ, Chen F, Ding ZM, Yang SJ, Chen YW, Duan ZQ, Liu M, Liang AX, He CJ, Hua GH, Huo LJ. | 05/7/2022 |
| WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. | WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.
Ho UY, Feng CA, Yeap YY, Bain AL, Wei Z, Shohayeb B, Reichelt ME, Homer H, Khanna KK, Bowles J, Ng DCH., Free PMC Article | 08/21/2021 |
| WDR62 is a novel participator in spindle migration and asymmetric cytokinesis during mouse oocyte meiotic maturation. | WDR62 is a novel participator in spindle migration and asymmetric cytokinesis during mouse oocyte meiotic maturation.
Wang YS, Jiao XF, Chen F, Wu D, Ding ZM, Miao YL, Huo LJ. | 10/31/2020 |
| The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. | The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.
Shohayeb B, Ho U, Yeap YY, Parton RG, Millard SS, Xu Z, Piper M, Ng DCH. | 10/24/2020 |
| WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis | WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis.
Qin Y, Zhou Y, Shen Z, Xu B, Chen M, Li Y, Chen M, Behrens A, Zhou J, Qi X, Meng W, Wang Y, Gao F. | 06/27/2020 |
| Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium. | Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
Zhang W, Yang SL, Yang M, Herrlinger S, Shao Q, Collar JL, Fierro E, Shi Y, Liu A, Lu H, Herring BE, Guo ML, Buch S, Zhao Z, Xu J, Lu Z, Chen JF., Free PMC Article | 07/13/2019 |
| Wdr62 is involved in meiotic initiation via activating JNK signaling, which displays a novel mechanism for regulating meiotic initiation, and mutation of WDR62 is one of the potential etiologies of premature ovarian insufficiency in humans. | Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans.
Zhou Y, Qin Y, Qin Y, Xu B, Guo T, Ke H, Chen M, Zhang L, Han F, Li Y, Chen M, Behrens A, Wang Y, Xu Z, Chen ZJ, Gao F., Free PMC Article | 01/19/2019 |
| Our findings demonstrate critical and diverse functions of WDR62 in neocortical development and provide insight into the mechanisms by which its disruption leads to a plethora of structural abnormalities. | Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.
Sgourdou P, Mishra-Gorur K, Saotome I, Henagariu O, Tuysuz B, Campos C, Ishigame K, Giannikou K, Quon JL, Sestan N, Caglayan AO, Gunel M, Louvi A., Free PMC Article | 11/10/2018 |
| Aspm and Wdr62 interact genetically to control brain size, with mice lacking Wdr62, Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and increased ectopic basal progenitors, suggesting premature delamination from the ventricular zone. | Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.
Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA., Free PMC Article | 07/29/2017 |
| Wdr62 interacts with Aurora A to control mitotic progression, and loss of these interactions leads to mitotic delay and cell death of NPCs, which could be a potential cause of human microcephaly. | Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size.
Chen JF, Zhang Y, Wilde J, Hansen KC, Lai F, Niswander L., Free PMC Article | 10/3/2015 |
| A key role for WDR62 in metaphase spindle organization, required for normal mitotic progression. | WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression.
Bogoyevitch MA, Yeap YY, Qu Z, Ngoei KR, Yip YY, Zhao TT, Heng JI, Ng DC., Free PMC Article | 06/15/2013 |
| In mice and humans, WDR62 transcripts and protein are enriched in neural progenitors within the ventricular and subventricular zones. | Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.
Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoğlu D, Tüysüz B, Cağlayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioğlu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandaş S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW, Günel M., Free PMC Article | 10/23/2010 |