| E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-kappaB pathway activation in pancreatitis and pancreatic cancer. | E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer.
Tan P, Cai S, Huang Z, Li M, Liu S, Chen J, Fu W, Zhao L. | 03/4/2024 |
| Expression of FBXW11 in normal and disease-associated osteogenic cells. | Expression of FBXW11 in normal and disease-associated osteogenic cells.
Dalle Carbonare L, Gomez Lira M, Minoia A, Bertacco J, Orsi S, Lauriola A, Li Vigni V, Gandini A, Antoniazzi F, Zipeto D, Mottes M, Bhandary L, Guardavaccaro D, Valenti MT., Free PMC Article | 06/15/2023 |
| Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma. | Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.
Chen C, Zhou H, Zhang X, Liu Z, Ma X. | 01/7/2023 |
| F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A. | F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A.
Liu C, Chen X, Zhang L, Liu J, Li C, Zhao J, Pu J, Tang P, Liu B, Huang X. | 06/25/2022 |
| FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer. | FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer.
Yao J, Yang J, Yang Z, Wang XP, Yang T, Ji B, Zhang ZY., Free PMC Article | 02/5/2022 |
| The characteristics and roles of beta-TrCP1/2 in carcinogenesis. | The characteristics and roles of β-TrCP1/2 in carcinogenesis.
Bi Y, Cui D, Xiong X, Zhao Y. | 07/24/2021 |
| MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling. | MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling.
Zhang Q, Yin X, Zhang Y. | 04/24/2021 |
| findings support the role of FBXW11 in multiple developmental processes, including those involving the brain, eye, digits, and jaw | De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies.
Holt RJ, Young RM, Crespo B, Ceroni F, Curry CJ, Bellacchio E, Bax DA, Ciolfi A, Simon M, Fagerberg CR, van Binsbergen E, De Luca A, Memo L, Dobyns WB, Mohammed AA, Clokie SJH, Zazo Seco C, Jiang YH, Sørensen KP, Andersen H, Sullivan J, Powis Z, Chassevent A, Smith-Hicks C, Petrovski S, Antoniadi T, Shashi V, Gelb BD, Wilson SW, Gerrelli D, Tartaglia M, Chassaing N, Calvas P, Ragge NK., Free PMC Article | 04/4/2020 |
| Fbxw11 expression is upregulated in patients with ALL. High levels of Fbxw11 expression stimulate the proliferation of L1210 lymphocytic leukemia cells in vitro and promote tumor formation in vivo by regulating the cell cycle. Most importantly, activation of both the NF-kappaB and beta-catenin/TCF signaling pathways is involved in this process. | Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-κB and β-catenin/TCF signaling pathways.
Wang L, Feng W, Yang X, Yang F, Wang R, Ren Q, Zhu X, Zheng G., Free PMC Article | 03/28/2020 |
| USP9X promotes tumorigenesis and FBXW11 suppresses tumorigenesis through PTENalpha/beta. | PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.
Shen SM, Zhang C, Ge MK, Dong SS, Xia L, He P, Zhang N, Ji Y, Yang S, Yu Y, Zheng JK, Yu JX, Xia Q, Chen GQ. | 02/22/2020 |
| beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1. | β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.
Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K. | 01/9/2019 |
| SCF(FBXW11) bound, polyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the small GTPase RAP1 | Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.
Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB., Free PMC Article | 02/14/2015 |
| Data indicate that miR-106b-25 cluster (miR-106b, miR-93 and miR-25) targets the 3'UTR of the beta-TRCP2 transcript and increases the expression of Snail. | MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells.
Savita U, Karunagaran D. | 08/31/2013 |
| Knockdown of beta-TrCP1 and beta-TrCP2 attenuated the K48-linked ubiquitination and degradation of IRAK1. | β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation.
Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, Li X., Free PMC Article | 12/8/2012 |
| two splice variants of beta-transducin repeat containing protein 2 (BTRCP2) localise exclusively to either the nucleus or the cytosol. | Specificity, location and function of βTrCP isoforms and their splice variants.
Putters J, Slotman JA, Gerlach JP, Strous GJ. | 09/11/2012 |
| Data indicate that knockdown of beta-TrCP1 and beta-TrCP2 markedly reduced IL-17-induced, phosphorylation-dependent ubiquitination and degradation of Act1. | Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.
Shi P, Zhu S, Lin Y, Liu Y, Liu Y, Chen Z, Shi Y, Qian Y. | 03/31/2012 |
| FBXW11 may be the most likely candidate gene for the Holoprosencephaly and prexial polydactyly phenotype. | Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1.
Koolen DA, Herbergs J, Veltman JA, Pfundt R, van Bokhoven H, Stroink H, Sistermans EA, Brunner HG, Geurts van Kessel A, de Vries BBA. | 01/21/2010 |