| Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B. | Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B.
Anvar Z, Chakchouk I, Sharif M, Mahadevan S, Nasiotis ET, Su L, Liu Z, Wan YW, Van den Veyver IB., Free PMC Article | 09/8/2023 |
| Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function. | Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.
Jin L, Li T, Hong Y, Mao R, Li X, Zhu C, Mu J, Zhou J, Pan L, Que Y, Xia Y, Zhang Y, Li S. | 09/7/2023 |
| Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect. | Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect.
Arian S, Rubin J, Chakchouk I, Sharif M, Mahadevan SK, Erfani H, Shelly K, Liao L, Lorenzo I, Ramakrishnan R, Van den Veyver IB., Free PMC Article | 01/15/2022 |
| Activation of the NLRP2 inflammasome leads to activation of dorsal root ganglion neurons and subsequent development of pain hypersensitivity. | NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity.
Matsuoka Y, Yamashita A, Matsuda M, Kawai K, Sawa T, Amaya F. | 08/1/2020 |
| NLRP2 might be a potential target for developing effective therapeutic strategy to prevent Nonalcoholic fatty liver disease progression. | Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress.
Li C, Liu Q, Xie L. | 05/18/2019 |
| Study shownd that apoptosis signal-regulating kinase 1 (ASK1) silencing and ASK1 inhibition reduced ischemic injury-induced nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 2 inflammasomes in the brain and astrocyte cell line, respectively. | Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke.
Cheon SY, Kim EJ, Kim SY, Kim JM, Kam EH, Park JK, Koo BN. | 03/23/2019 |
| female mice lacking NLRP2 are subfertile because of early embryonic loss and the production of fewer offspring that have a wide array of developmental phenotypes and abnormal DNA methylation at imprinted loci. | Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.
Mahadevan S, Sathappan V, Utama B, Lorenzo I, Kaskar K, Van den Veyver IB., Free PMC Article | 11/17/2018 |
| NLRP2 interacts with FAF1 under normal physiological conditions | NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse.
Peng H, Liu H, Liu F, Gao Y, Chen J, Huo J, Han J, Xiao T, Zhang W. | 04/28/2018 |
| This work identifies Nlrp2 as a critical regulator of oocyte quality | NLRP2 controls age-associated maternal fertility.
Kuchmiy AA, D'Hont J, Hochepied T, Lamkanfi M., Free PMC Article | 07/22/2017 |
| high expression of NLRP2, especially in astrocytes, may play important roles in the pathophysiological process of ischemic stroke and has potential clinical value for the treatment of ischemic stroke. | NLRP2 is highly expressed in a mouse model of ischemic stroke.
Sun X, Song X, Zhang L, Sun J, Wei X, Meng L, An J. | 05/27/2017 |
| Nlrp2 is a member of the mammalian maternal effect genes and required for early embryonic development in the mouse. | Nlrp2, a maternal effect gene required for early embryonic development in the mouse.
Peng H, Chang B, Lu C, Su J, Wu Y, Lv P, Wang Y, Liu J, Zhang B, Quan F, Guo Z, Zhang Y., Free PMC Article | 06/9/2012 |
| POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix | Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.
Atianand MK, Harton JA., Free PMC Article | 01/21/2012 |