| Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. | Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway.
Yakout DW, Shroff A, Wei W, Thaker V, Allen ZD, Sajish M, Nazarko TY, Mabb AM., Free PMC Article | 06/5/2024 |
| Gut-derived 4-hydroxyphenylacetic acid attenuates sepsis-induced acute kidney injury by upregulating ARC to inhibit necroptosis. | Gut-derived 4-hydroxyphenylacetic acid attenuates sepsis-induced acute kidney injury by upregulating ARC to inhibit necroptosis.
An S, Yao Y, Wu J, Hu H, Wu J, Sun M, Li J, Zhang Y, Li L, Qiu W, Li Y, Deng Z, Fang H, Gong S, Huang Q, Chen Z, Zeng Z. | 11/16/2023 |
| Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage. | Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage.
Chen T, Xu YP, Chen Y, Sun S, Yan ZZ, Wang YH. | 10/24/2023 |
| NMDA Receptor-Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer's Disease. | NMDA Receptor-Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer's Disease.
Yang L, Liu W, Shi L, Wu J, Zhang W, Chuang YA, Redding-Ochoa J, Kirkwood A, Savonenko AV, Worley PF., Free PMC Article | 10/4/2023 |
| Arc and Homer1 are involved in comorbid epilepsy and depression: A microarray data analysis. | Arc and Homer1 are involved in comorbid epilepsy and depression: A microarray data analysis.
Yu S, Wang G, Yao B, Xiao L, Tuo H. | 06/25/2022 |
| Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. | Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif.
Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR. | 07/24/2021 |
| Activity-regulated cytoskeleton-associated protein predicts symptom response to cognitive behavioral therapy among individuals with first-episode psychosis. | Activity-regulated cytoskeleton-associated protein predicts symptom response to cognitive behavioral therapy among individuals with first-episode psychosis.
Pine JG, Moe AM, Maple AM, Gallitano AL, Breitborde NJK. | 02/6/2021 |
| Activity-Regulated Cytoskeleton-Associated Protein (Arc/Arg3.1) is Transiently Expressed after Heat Shock Stress and Suppresses Heat Shock Factor 1. | Activity-Regulated Cytoskeleton-Associated Protein (Arc/Arg3.1) is Transiently Expressed after Heat Shock Stress and Suppresses Heat Shock Factor 1.
Park AY, Park YS, So D, Song IK, Choi JE, Kim HJ, Lee KJ., Free PMC Article | 09/26/2020 |
| Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag. | Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag.
Cottee MA, Letham SC, Young GR, Stoye JP, Taylor IA., Free PMC Article | 09/19/2020 |
| Multiscale Imaging Reveals Aberrant Functional Connectome Organization and Elevated Dorsal Striatal Arc Expression in Advanced Age. | Multiscale Imaging Reveals Aberrant Functional Connectome Organization and Elevated Dorsal Striatal Arc Expression in Advanced Age.
Colon-Perez LM, Turner SM, Lubke KN, Pompilus M, Febo M, Burke SN., Free PMC Article | 09/12/2020 |
| Our data highlighted that PCAT6 acts as a key activator of ARC expression by forming a complex with EZH2, inhibiting cell apoptosis and contributing to colon cancer progression. These findings elucidated that PCAT6 may be a novel prognostic predictor and therapeutic target of colon cancer | Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2.
Huang W, Su G, Huang X, Zou A, Wu J, Yang Y, Zhu Y, Liang S, Li D, Ma F, Guo L., Free PMC Article | 02/22/2020 |
| The findings have important implications for the structural organization of ARC with respect to distinct functions, such as postsynaptic signal transduction and virus-like capsid formation | Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities.
Hallin EI, Eriksen MS, Baryshnikov S, Nikolaienko O, Grødem S, Hosokawa T, Hayashi Y, Bramham CR, Kursula P. | 09/28/2019 |
| Our results indicated that the Arc gene would confer susceptibility to Alzheimer disease in Han Chinese, probably through changing the protein structure or affecting the Arc expression in brain tissues, which would finally contribute to the pathogenesis and development of AD. | The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese.
Bi R, Kong LL, Xu M, Li GD, Zhang DF, Alzheimer’s Disease Neuroimaging Initiative, Li T, Fang Y, Zhang C, Zhang B, Yao YG. | 01/12/2019 |
| The ARC complex revealed association with verbal and total IQ in child. | Implication of the APP Gene in Intellectual Abilities.
Myrum C, Nikolaienko O, Bramham CR, Haavik J, Zayats T., Free PMC Article | 04/14/2018 |
| Study identified several rare mutations that reduced ARC expression in schizophrenia patients. Furthermore, DNA methylation of ARC in schizophrenia patients may be associated with a downregulation of ARC mRNA expression. These findings suggest that multiple rare ARC variants and DNA methylation of ARC might contribute to the pathogenesis of schizophrenia. | Rare mutations and hypermethylation of the ARC gene associated with schizophrenia.
Chuang YA, Hu TM, Chen CH, Hsu SH, Tsai HY, Cheng MC. | 12/23/2017 |
| missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation. | TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation.
Husain N, Yuan Q, Yen YC, Pletnikova O, Sally DQ, Worley P, Bichler Z, Shawn Je H., Free PMC Article | 06/24/2017 |
| ARC confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways | Decreased apoptosis repressor with caspase recruitment domain confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways.
Gobe GC, Ng KL, Small DM, Vesey DA, Johnson DW, Samaratunga H, Oliver K, Wood S, Barclay JL, Rajandram R, Li L, Morais C. | 09/24/2016 |
| We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS). | Common variants in the ARC gene are not associated with cognitive abilities.
Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold AJ, Haavik J, Nilsson LG, Reinvang I, Steen VM, Johansson S, Wibrand K, Le Hellard S, Bramham CR., Free PMC Article | 08/27/2016 |
| this is the first report associating an ARC SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC complex in schizophrenia risk | Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.
Huentelman MJ, Muppana L, Corneveaux JJ, Dinu V, Pruzin JJ, Reiman R, Borish CN, De Both M, Ahmed A, Todorov A, Cloninger CR, Zhang R, Ma J, Gallitano AL., Free PMC Article | 06/4/2016 |
| we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior could explain how familiarization and recognition memories are stored and preserved in the mammalian brain--{REVIEW} | New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc.
Morin JP, Guzmán-Ramos K, Bermudez-Rattoni F., Free PMC Article | 04/23/2016 |
| mRNA levels of ARC and SGK1 did not differ significantly between the schizophrenia or control samples. | Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene.
Kimoto S, Zaki MM, Bazmi HH, Lewis DA., Free PMC Article | 10/31/2015 |
| Arc is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes. | Arc is a flexible modular protein capable of reversible self-oligomerization.
Myrum C, Baumann A, Bustad HJ, Flydal MI, Mariaule V, Alvira S, Cuéllar J, Haavik J, Soulé J, Valpuesta JM, Márquez JA, Martinez A, Bramham CR., Free PMC Article | 07/25/2015 |
| Degradation of Arc by clathrin-localized Triad3A regulates the availability of synaptic AMPA receptors. | Triad3A regulates synaptic strength by ubiquitination of Arc.
Mabb AM, Je HS, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SA, Ehlers MD., Free PMC Article | 08/16/2014 |
| we report a novel ARC single nucleotide polymorphism associated with a reduced risk of developing Alzheimer disease. | A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease.
Landgren S, von Otter M, Palmér MS, Zetterström C, Nilsson S, Skoog I, Gustafson DR, Minthon L, Wallin A, Andreasen N, Bogdanovic N, Marcusson J, Blennow K, Zetterberg H, Kettunen P. | 11/17/2012 |
| analysis of dynamic, multifaceted control of Arc synthesis during mAchR signaling | Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation.
Soulé J, Alme M, Myrum C, Schubert M, Kanhema T, Bramham CR., Free PMC Article | 09/22/2012 |