| WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma. | WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
Li L, Xie D, Yu S, Ma M, Fan K, Chen J, Xiu M, Xie K, Li Y, Gao Y. | 10/25/2024 |
| Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance. | Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance.
Ferdaus MZ, Terker AS, Koumangoye RB, Al-Qusairi L, Welling PA, Delpire E., | 08/28/2024 |
| KS-WNK1 is required for the renal response to extreme changes in potassium intake. | KS-WNK1 is required for the renal response to extreme changes in potassium intake.
Bahena-Lopez JP, Vergara L, de la-Peña V, Gutierrez-Gallardo MA, López-Ibargüen P, García JA, Contreras-Carbajal H, Vázquez N, Rincón-Heredia R, Masso F, Bobadilla NA, Castañeda-Bueno M, Ellison DH, Gamba G, Chávez-Canales M., | 06/28/2024 |
| CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1. | CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1.
Jiang G, Cai Y, Cheng D, Wang H, Deng G, Xiang D., Free PMC Article | 04/5/2024 |
| WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release. | WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release.
Jin X, Xie J, Yeh CW, Chen JC, Cheng CJ, Lien CC, Huang CL., Free PMC Article | 06/7/2023 |
| B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice. | B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
Hayward DA, Vanes L, Wissmann S, Sivapatham S, Hartweger H, Biggs O'May J, de Boer LL, Mitter R, Köchl R, Stein JV, Tybulewicz VLJ., Free PMC Article | 02/4/2023 |
| WNK1 in the kidney. | WNK1 in the kidney.
Bahena-Lopez JP, Gamba G, Castañeda-Bueno M. | 12/2/2022 |
| WNK1 collaborates with TGF-beta in endothelial cell junction turnover and angiogenesis. | WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis.
Jaykumar AB, Plumber S, Barry DM, Binns D, Wichaidit C, Grzemska M, Earnest S, Goldsmith EJ, Cleaver O, Cobb MH., Free PMC Article | 08/6/2022 |
| Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1. | Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1.
Li Q, Zang Y, Sun Z, Zhang W, Liu H., Free PMC Article | 02/19/2022 |
| L-WNK1 is required for BK channel activation in intercalated cells. | L-WNK1 is required for BK channel activation in intercalated cells.
Ray EC, Carrisoza-Gaytan R, Al-Bataineh M, Marciszyn AL, Nkashama LJ, Chen J, Winfrey A, Griffiths S, Lam TR, Flores D, Wu P, Wang W, Huang CL, Subramanya AR, Kleyman TR, Satlin LM., Free PMC Article | 09/25/2021 |
| Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis. | Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.
Mayes-Hopfinger L, Enache A, Xie J, Huang CL, Köchl R, Tybulewicz VLJ, Fernandes-Alnemri T, Alnemri ES., Free PMC Article | 08/7/2021 |
| Role of KLHL3 and dietary K(+) in regulating KS-WNK1 expression. | Role of KLHL3 and dietary K(+) in regulating KS-WNK1 expression.
Ostrosky-Frid M, Chávez-Canales M, Zhang J, Andrukhova O, Argaiz ER, Lerdo-de-Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castañeda-Bueno M, Alessi DR, Gamba G., Free PMC Article | 05/15/2021 |
| Critical role of WNK1 in MYC-dependent early mouse thymocyte development. | Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
Köchl R, Vanes L, Llorian Sopena M, Chakravarty P, Hartweger H, Fountain K, White A, Cowan J, Anderson G, Tybulewicz VL., Free PMC Article | 02/27/2021 |
| Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis. | Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X., Free PMC Article | 02/20/2021 |
| Potassium acts through mTOR to regulate its own secretion. | Potassium acts through mTOR to regulate its own secretion.
Sørensen MV, Saha B, Jensen IS, Wu P, Ayasse N, Gleason CE, Svendsen SL, Wang WH, Pearce D., Free PMC Article | 09/19/2020 |
| WNK kinase-dependent pathway can affect both the trafficking as well as intrinsic activity of NKCC2. | Regulation of Na(+)-K(+)-Cl(-) cotransporter type 2 by the with no lysine kinase-dependent signaling pathway.
Marcoux AA, Slimani S, Tremblay LE, Frenette-Cotton R, Garneau AP, Isenring P. | 03/28/2020 |
| These findings suggest that WNK1 is involved in the physiological regulation of mammalian skeletal muscle hypertrophy and atrophy via interactions with FOXO4. | WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4.
Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S., Free PMC Article | 10/12/2019 |
| Although these results confirm that familial hyperkalemic hypertension caused by WNK1 mutations is dependent on the activation of SPAK, they suggest that WNK1 and WNK4 play different roles in the distal nephron. | Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.
Rafael C, Soukaseum C, Baudrie V, Frère P, Hadchouel J., Free PMC Article | 09/28/2019 |
| WNK1 is required for high potassium intake-induced stimulation of ROMK activity in convoluted kidney tubules. | Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K(+) intake on ROMK channel in the distal convoluted tubule.
Wu P, Gao ZX, Su XT, Ellison DH, Hadchouel J, Teulon J, Wang WH., Free PMC Article | 07/13/2019 |
| Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade. | Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade.
Zheng S, Krump NA, McKenna MM, Li YH, Hannemann A, Garrett LJ, Gibson JS, Bodine DM, Low PS., Free PMC Article | 05/4/2019 |
| The formation of WNK bodies requires an evolutionarily conserved cysteine-rich hydrophobic motif harbored within a unique N-terminal exon of KS-WNK1. It is proposed that WNK bodies are not pathological aggregates, but rather are KS-WNK1-dependent microdomains of the DCT cytosol that modulate WNK signaling during physiological shifts in potassium balance. | Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent.
Boyd-Shiwarski CR, Shiwarski DJ, Roy A, Namboodiri HN, Nkashama LJ, Xie J, McClain KL, Marciszyn A, Kleyman TR, Tan RJ, Stolz DB, Puthenveedu MA, Huang CL, Subramanya AR., Free PMC Article | 01/12/2019 |
| GABAAR-dependent regulation of KCC2 diffusion involves phosphorylation of its T906/T1007 residues by WNK1. | GABA(A) receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl(-)-sensitive WNK1 kinase.
Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, Poncer JC, Lévi S., Free PMC Article | 12/22/2018 |
| reduced age-dependent weight gain of WNK1 TG mice seems to be related with the decreased Kir6.2 expression via WNK1- and WNK4-regulated protein stability of Kir6.2. | Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2.
Chung WY, Han JW, Heo W, Lee MG, Kim JY. | 11/3/2018 |
| The differential regulation of ROMK, large-conductance Ca(2+)-activated K(+) (BK) channel, BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control. | Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure.
Yu G, Cheng M, Wang W, Zhao R, Liu Z. | 06/24/2017 |
| this study identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration | WNK1 kinase balances T cell adhesion versus migration in vivo.
Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL., Free PMC Article | 06/24/2017 |