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    Foxi3 forkhead box I3 [ Mus musculus (house mouse) ]

    Gene ID: 232077, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of potential molecular mechanism related to craniofacial dysmorphism caused by FOXI3 deficiency.

    Identification of potential molecular mechanism related to craniofacial dysmorphism caused by FOXI3 deficiency.
    Xing XL, Zeng Z, Wang Y, Pan B, Huang X., Free PMC Article

    03/6/2024
    The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border.

    The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border.
    Thawani A, Maunsell HR, Zhang H, Ankamreddy H, Groves AK., Free PMC Article

    11/7/2023
    FOXI3 pathogenic variants cause one form of craniofacial microsomia.

    FOXI3 pathogenic variants cause one form of craniofacial microsomia.
    Mao K, Borel C, Ansar M, Jolly A, Makrythanasis P, Froehlich C, Iwaszkiewicz J, Wang B, Xu X, Li Q, Blanc X, Zhu H, Chen Q, Jin F, Ankamreddy H, Singh S, Zhang H, Wang X, Chen P, Ranza E, Paracha SA, Shah SF, Guida V, Piceci-Sparascio F, Melis D, Dallapiccola B, Digilio MC, Novelli A, Magliozzi M, Fadda MT, Streff H, Machol K, Lewis RA, Zoete V, Squeo GM, Prontera P, Mancano G, Gori G, Mariani M, Selicorni A, Psoni S, Fryssira H, Douzgou S, Marlin S, Biskup S, De Luca A, Merla G, Zhao S, Cox TC, Groves AK, Lupski JR, Zhang Q, Zhang YB, Antonarakis SE., Free PMC Article

    04/14/2023
    Study discovered that Tbx1 and Foxi3 factors interact at minimum, in the third pharyngeal pouch endoderm, needed to form the thymus and parathyroid glands. Iinactivation of Foxi3 results in cardiovascular anomalies. Global inactivation of Tbx1 and Foxi3 both result in failure of the epithelia to properly invaginate along with an expansion of multilayers of pharyngeal endoderm cells.

    Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome.
    Hasten E, Morrow BE., Free PMC Article

    01/11/2020
    Foxi3 regulates multiple aspects of hair follicle development and homeostasis.

    Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.
    Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML, Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML., Free PMC Articles: PMC5287380, PMC5287380

    12/9/2017
    Foxi3 regulates specification of hair follicle stem cell in embryogenesis, and is essential for hair follicle activation during hair regeneration.

    Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.
    Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML, Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML., Free PMC Articles: PMC5287380, PMC5287380

    11/25/2016
    Foxi3 is necessary to prime pre-placodal ectoderm for the correct interpretation of inductive signals for the otic and epibranchial placodes.

    The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.
    Birol O, Ohyama T, Edlund RK, Drakou K, Georgiades P, Groves AK., Free PMC Article

    05/28/2016
    Foxi3 maintains dental epithelial cells in an undifferentiated state and thereby regulates multiple stages of tooth morphogenesis.

    Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning.
    Jussila M, Aalto AJ, Sanz Navarro M, Shirokova V, Balic A, Kallonen A, Ohyama T, Groves AK, Mikkola ML, Thesleff I., Free PMC Article

    03/5/2016
    Data indicate that Foxi3 mutants succumb to apoptosis from embryonic day 9.75 onwards, and this cell death correlates with a delay in expression of Fgf8 in branchial arch ectoderm.

    Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
    Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK., Free PMC Article

    06/21/2014
    Eda and activin A are upstream regulators of Foxi3 in skin appendage placodes

    Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes.
    Shirokova V, Jussila M, Hytönen MK, Perälä N, Drögemüller C, Leeb T, Lohi H, Sainio K, Thesleff I, Mikkola ML.

    01/4/2014
    Foxi3 expressed in a broad region of the pan-placodal ectoderm adjacent to the neural plate from E6.75 to first somite stage; expression restricted to ectoderm & endoderm of branchial pouches at E10.5

    Expression of mouse Foxi class genes in early craniofacial development.
    Ohyama T, Groves AK.

    01/21/2010
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