| P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress. | P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress.
Kuang XJ, Zhang CY, Yan BY, Cai WZ, Lu CL, Xie LJ, Li SJ, Kong PL, Fan J, Pan SM, Guo T, Cao X., Free PMC Article | 06/11/2022 |
| Generation and characterization of a P2rx2 V60L mouse model for DFNA41. | Generation and characterization of a P2rx2 V60L mouse model for DFNA41.
Chen X, Abad C, Chen ZY, Young JI, Gurumurthy CB, Walz K, Liu XZ., Free PMC Article | 03/5/2022 |
| BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors. | BAC transgenic mice to study the expression of P2X2 and P2Y(1) receptors.
Grohmann M, Schumacher M, Günther J, Singheiser SM, Nußbaum T, Wildner F, Gerevich Z, Jabs R, Hirnet D, Lohr C, Illes P, Schmalzing G, Franke H, Hausmann R., Free PMC Article | 02/19/2022 |
| Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge. | Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge.
Kong Y, Wang Q, Wu DY, Hu J, Zang WS, Li XW, Yang JM, Gao TM. | 08/21/2021 |
| P2RX2 and P2RX4 receptors mediate cation absorption in transitional cells and supporting cells of the utricular macula. | P2RX2 and P2RX4 receptors mediate cation absorption in transitional cells and supporting cells of the utricular macula.
Jeong J, Kim JY, Hong H, Wangemann P, Marcus DC, Jung J, Choi JY, Kim SH. | 06/5/2021 |
| P2X2 receptors are mainly localized in the supporting cells of the vestibular inner ear, and loss of P2X2 receptors causes mild vestibular dysfunction. | P2X(2) Receptor Deficiency in Mouse Vestibular End Organs Attenuates Vestibular Function.
Takimoto Y, Ishida Y, Kondo M, Imai T, Hanada Y, Ozono Y, Kamakura T, Inohara H, Shimada S. | 03/16/2019 |
| These results indicate that the P2X2aR is a novel target for Cdk5-mediated phosphorylation, which might play important physiological roles including pain signaling. | Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.
Coddou C, Sandoval R, Castro P, Lazcano P, Hevia MJ, Rokic M, Hall B, Terse A, Gonzalez-Billault C, Kulkarni AB, Stojilkovic SS, Utreras E., Free PMC Article | 06/9/2018 |
| results indicate that the lateral border of the P2X2 terminal field, demarcates a faithful "transition zone," where AO responses transition from gustatory to mechanosensory | P2X2 Receptor Terminal Field Demarcates a "Transition Zone" for Gustatory and Mechanosensory Processing in the Mouse Nucleus Tractus Solitarius.
Breza JM, Travers SP., Free PMC Article | 06/24/2017 |
| may be involved in skeletal pain due to high bone turnover | Acid-sensing ion channel 3 or P2X2/3 is involved in the pain-like behavior under a high bone turnover state in ovariectomized mice.
Kanaya K, Iba K, Abe Y, Dohke T, Okazaki S, Matsumura T, Yamashita T. | 08/20/2016 |
| Obesity promotes down regulation of P2rx2 receptor expression in enteric neurons innervating the ileum. | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob).
Mizuno MS, Crisma AR, Borelli P, Schäfer BT, Silveira MP, Castelucci P., Free PMC Article | 06/27/2015 |
| This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice. | Maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice.
Sclafani A, Ackroff K., Free PMC Article | 02/7/2015 |
| Purinergic signaling is important for cell fate determination during neural differentiation, with P2X2 and P2X7 receptors promoting neurogenesis and gliogenesis, respectively. | Regulation of neurogenesis and gliogenesis of retinoic acid-induced P19 embryonal carcinoma cells by P2X2 and P2X7 receptors studied by RNA interference.
Yuahasi KK, Demasi MA, Tamajusuku AS, Lenz G, Sogayar MC, Fornazari M, Lameu C, Nascimento IC, Glaser T, Schwindt TT, Negraes PD, Ulrich H. | 11/17/2012 |
| results show that sufficient endogenous ATP is released by bursts of action potentials to act at P2X2 receptors to modulate neuropeptide release. | P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis.
Custer EE, Knott TK, Cuadra AE, Ortiz-Miranda S, Lemos JR., Free PMC Article | 07/28/2012 |
| P2X2 is expressed in WT taste buds and appears to function as an autocrine, positive feedback signal to amplify taste-evoked ATP secretion. | Knocking out P2X receptors reduces transmitter secretion in taste buds.
Huang YA, Stone LM, Pereira E, Yang R, Kinnamon JC, Dvoryanchikov G, Chaudhari N, Finger TE, Kinnamon SC, Roper SD., Free PMC Article | 12/10/2011 |
| ATP-induced current on mouse spermatozoa is mediated by the P2X2 purinergic receptor/channel. | ATP-activated P2X2 current in mouse spermatozoa.
Navarro B, Miki K, Clapham DE., Free PMC Article | 10/29/2011 |
| GABA(A) receptor dynamics are regulated by interaction with purinergic P2X(2) receptors | Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors.
Shrivastava AN, Triller A, Sieghart W, Sarto-Jackson I., Free PMC Article | 07/2/2011 |
| Transcripts for P2X2 were present in nearly all colon neurons examined. | Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity.
Shinoda M, La JH, Bielefeldt K, Gebhart GF., Free PMC Article | 05/14/2011 |
| Review illustrates how density-dependent changes in the P2X2 receptor pore properties have potential implications for physiological regulation by changing the local density of the channel at a synapse and in turn the dynamic properties of the synapse. | Dynamic aspects of functional regulation of the ATP receptor channel P2X2.
Kubo Y, Fujiwara Y, Keceli B, Nakajo K., Free PMC Article | 08/2/2010 |
| In brief access tests, double P2X2/P2X3 purinergic receptor null mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors. | Residual chemosensory capabilities in double P2X2/P2X3 purinergic receptor null mice: intraoral or postingestive detection?
Hallock RM, Tatangelo M, Barrows J, Finger TE., Free PMC Article | 02/1/2010 |
| Data suggest that double P2X2/P2X3 purinergic receptor knockout mice are unable to respond to NaCl or the artificial sweetener SC45647 as taste stimuli, mirroring the lack of gustatory nerve responses to these substances. | Double P2X2/P2X3 purinergic receptor knockout mice do not taste NaCl or the artificial sweetener SC45647.
Eddy MC, Eschle BK, Barrows J, Hallock RM, Finger TE, Delay ER., Free PMC Article | 02/1/2010 |
| This study provides the first evidence that P2X2 receptors are expressed on LHRH-containing neurons. | P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus.
Fu J, Yu Q, Guo W, He C, Burnstock G, Xiang Z. | 01/21/2010 |
| AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors. | Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors.
Wildman SS, Boone M, Peppiatt-Wildman CM, Contreras-Sanz A, King BF, Shirley DG, Deen PM, Unwin RJ., Free PMC Article | 01/21/2010 |
| VILIP1 constitutively binds to P2X2 receptors and displays enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors | Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1.
Chaumont S, Compan V, Toulme E, Richler E, Housley GD, Rassendren F, Khakh BS., Free PMC Article | 01/21/2010 |
| These findings demonstrate a role for P2X2 receptor-mediated signaling in NMJ formation and suggest that purinergic signaling may play an as yet largely unrecognized part in synapse formation. | Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor.
Ryten M, Koshi R, Knight GE, Turmaine M, Dunn P, Cockayne DA, Ford AP, Burnstock G. | 01/21/2010 |
| Show expression of P2X2 and P2X7 in taste bud cells. | Functional expression of ionotropic purinergic receptors on mouse taste bud cells.
Hayato R, Ohtubo Y, Yoshii K., Free PMC Article | 01/21/2010 |